Protein Alignment HEATR3 and CG10286

DIOPT Version :10

• Sequence 1: NP_891552.1
• Gene: HEATR3 / 55027
• HGNCID: 26087
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_649649.1
• Gene: CG10286 / 40786
• FlyBaseID: FBgn0037439
• Length: 625
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 187/689 - (27%)
• Similarity: 320/689 - (46%)
• Gaps: 90/689 - (13%)

Human     1 MGKSRTKRFKRPQ-FSPTGDCQAEAAAAANGTGGEEDDGPAAELLEKLQHPSAEVRECACAGLAR 64
            |||.|..:.:.|. ...:.:...|:|..|.|.      ||...:...||..:.|.:.......|.
  Fly     1 MGKVRKVKTRTPSGVDTSAEIDVESAGEAEGC------GPIEAICVHLQQANVEEKLNGLHSFAV 59

Human    65 LVQQRPALPGLARRDAVRRLGPLLLDPSLAVRETAAGALRNLSACGGFEVCDDMVTKDIMTPLVA 129
            |..::..:|.:...:.||...|||.|...|:|..||||.||||.. |.||||.:|..||:|.|:.
  Fly    60 LALRKEKVPEIRDSELVRIAAPLLCDKESAIRNAAAGAFRNLSVF-GTEVCDFLVENDILTALLT 123

Human   130 LLK--ECSAGLDSNEMSLQEKKDQNRNSIENIANETVNVLWNICECSSRAVSIFNKEGCLEIVLK 192
            |::  :.:.|...||:.            .:...:.:::|.|:||.|..|....|:...|..:|.
  Fly   124 LVRSYDLTKGGFENELH------------ADTFQQAIHLLRNLCESSPTATEALNQANFLSSLLL 176

Human   193 YLSRFPTNVDLAISVAYCLQTVTEDNPELLKSFSATALNMLESA------LLSPVSSMESLLLKT 251
            ........:::|||||..:..|:|:|        :::.|:|.|:      |::|..|...|.|..
  Fly   177 GFDYRKFGLEVAISVAQLVLVVSENN--------SSSWNVLASSTILPELLVAPTESHAQLYLNA 233

Human   252 LVAGTIWNLKDIIPCKSQA---EIINALLKILSEVLGMDAGEMVIQMKEAETQRLKTAAEAEEIL 313
            |.||.:.|    :|..:.|   ||:|:|.|:||    :|. :..:|..::|....|:..||..:.
  Fly   234 LAAGILCN----VPACAAAHTREILNSLDKLLS----IDP-QAQLQSCKSEILNAKSKNEAPVLE 289

Human   314 ENTNGDDLIEDDEMEGISHKRRVRRKTFVSDLLPPTDKELRETIALLTAQQTALEIIVNMCCNED 378
            .:...:|:.|.....        :.|....|    .:..|:....||.||:...|||.|:..:::
  Fly   290 ISMETEDMTETQSAN--------QSKPNQCD----AEVALKNLEHLLDAQRLVAEIITNLGSSDE 342

Human   379 PSDDEWEELSSSDESDAF----MENSFSECG-GQLFSPLCLSHEVHTALTNYLIPKKIFEKTAFP 438
            .|:  |:..|...||::.    ||:..::.| |.|  |   ::.:.|...|.:| :|:::| |.|
  Fly   343 QSN--WDTDSEHSESESVADYDMEDETADSGSGGL--P---ANFLETIKQNKVI-EKLWQK-AQP 398

Human   439 NSIAVD-LCSRNPTWKPLIRKMNTIQCRALFCLQSLVSLLDVEHLGGAAALQTLAQHLSQLLFSQ 502
            ...||: |.|:....|   .|:..::...|.|||:|.::|..|.|||.:.|..:...|.|..|..
  Fly   399 LQPAVENLVSQQENIK---EKVEKLRVSYLICLQNLCNVLPPEDLGGCSNLYNMWMILGQQAFRG 460

Human   503 PDFAKHVDFLEAISSALRALLQTMAS-KNISQCMTPDQLMTLCKAGIHSSNVGVRVNVVSILGIT 566
               ::.|..:|||:|.:|:.|..:.| |::...||.:.|..:.:.....:::.:|||...:||..
  Fly   461 ---SEDVSVMEAITSLMRSSLSLLKSRKDLFGQMTENDLNMIIEGASKCTDINIRVNWNRMLGTL 522

Human   567 GSVLAKEDGTLETLKNIGCFLLEVTTKDPSLVVAGEALDALFDVFADGKEAERASIQIKLLSALK 631
            ||:|::     ..:|.|..|||....::..|....|.||||.|:|| ..:..:...::::...::
  Fly   523 GSLLSE-----PLVKAIVLFLLTYCAQEDDLWALSEGLDALMDIFA-VDDWPQIIAELEMCDRVQ 581

Human   632 EFQPVFKMKIRKEGRGNYSTDQLCVLDNVKMNLRRFIAY 670
            ..:.:||.|:|::.|  ...::...:..||.|..||:.|
  Fly   582 ALEELFKSKLRQQRR--ELKERRATVQTVKTNFSRFVFY 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HEATR3	NP_891552.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		9/38 (24%)
		Syo1_like	2..673	CDD:240521	186/688 (27%)
		HEAT 1	38..69		7/30 (23%)
		armadillo repeat	69..108	CDD:293788	16/38 (42%)
		HEAT 2	74..110		16/35 (46%)
		armadillo repeat	115..170	CDD:293788	12/56 (21%)
CG10286	NP_649649.1	Syo1_like	41..621	CDD:474028	176/643 (27%)