Protein Alignment BANK1 and stumps

DIOPT Version :10

• Sequence 1: NP_060405.5
• Gene: BANK1 / 55024
• HGNCID: 18233
• Length: 785
• Species: Homo sapiens
• Sequence 2: NP_731923.2
• Gene: stumps / 41770
• FlyBaseID: FBgn0020299
• Length: 1220
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 177/923 - (19%)
• Similarity: 325/923 - (35%)
• Gaps: 313/923 - (33%)

Human     9 GLGSPDPAPCGPAP--------------------------------------PG-NTKDIIMIYE 34
            ||||||..|...||                                      || |..||::|..
  Fly   192 GLGSPDEVPSMMAPRPPLLSPNKFRGSSHRRRDNCGNVNNTSGSSASGFLGSPGYNMDDILIITA 256

Human    35 EDAEEWALYLTEVFL-----HVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLT 94
            :.:|.  .||...||     .:.|:..     .:.|:|.|:::                   |..
  Fly   257 KHSER--AYLRATFLKNHFDKITKQRG-----RKPFNFLHIKI-------------------DDG 295

Human    95 PKKCQFLEKILHSPKSV---VTLLCGVKSS-------DQLYELLNISQ---SRWEISTEQEPEDY 146
            |    |.|:|.|..::.   :.:||....:       .||..::.:.:   ...::|.|:..|.:
  Fly   296 P----FSEEIAHKYQNTALQIVILCPALLALPHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMH 356

Human   147 ISVIQS------IIFKDSEDYFEVN----IPTDLRAKHSGEISERKEIEE--------LSEASRN 193
            .|.:.|      .:.:|: |..:::    |.||:..:   .:.:|...::        ||.:..:
  Fly   357 KSALPSYYKWRRCVVRDN-DQVQISNILGIATDILGR---ALCQRPPCQDSSGGGGGGLSRSFSS 417

Human   194 TIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEF-- 256
            ......|||.::.......:.::.......||::::...|.:.|..|    |.|......|:|
  Fly   418 CTEGFTVLPKKVKLGQNKVVALLAEPLEKNDTLKLQVEKSGELIELR----NFKCRNPYTLQFNI 478

Human   257 PAGSVHVNVYCDGIVKATTK------IKYYPTAKAKECLFRMADSG-ESLCQ----NSIEE--LD 308
            |...:.::...:..::...|      ||.....:..|.|.|:.||. |.:|.    ..:|.  ||
  Fly   479 PEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPVERDALD 543

Human   309 GVLTSIFKHEI-PYYEFQSLQTEICSQNKYTHF--------KELPTLLHCAAKFGLKNLAIHLLQ 364
            ..|...|:..: |.:...|..:|     :..||        :|.|||||.||::||..|.|.|::
  Fly   544 QHLLQCFQRNMPPNFHLLSGPSE-----RQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQLME 603

Human   365 CSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPS 429
            |.|...|..::|..|..||.:||:.||.:|                      .::|.||:.:
  Fly   604 CPGGDTACGVRNCAGRTPAELAEQEGHHKL----------------------AQNIVSFAEF--- 643

Human   430 TQNPAFHHESRKTY---------GQSADGAEAN-EMEGE----GKQN--------------GSGM 466
                   ||....|         |:|.....|| .:|..    ||.|              .||.
  Fly   644 -------HELTTMYHYFKGVTPPGESCPKPSANVVIEAHPVKAGKTNKPPKELPTAEYMEMSSGS 701

Human   467 ETKHSPLEVGSESSEDQYDDL-YVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTL 530
            |.:::| ||.:::......:| |:.:...|  .|.|..:...:
  Fly   702 ERENTP-EVRTKTETLAISNLNYISVETED--ENLQASVAEKK---------------------- 741

Human   531 PGTMVEGQMERSQNWGHPGVRQETGD----EPKGEKEKKEEEKEQEEEEDPYTFAEID------- 584
                ||.:.:..:....||..:.|.:    ||...:.|::.::.:|.:....:..|:|
  Fly   742 ----VESEKKLPEAGNQPGPEKTTNELRINEPPYYQSKEQNQQPKELKNQSKSLDEVDAAPLYQT 802

Human   585 ---DSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDD 646
               ..|...:|.|     :.|: .:::        :|:::|..::...|:.|     .:.|..::
  Fly   803 DKFSQECSQLLEN-----QLGN-DYVL--------QPSNVPVAQDDGNYLFQ-----PSNRPVEE 848

Human   647 DKFCGLPKKQDRARIESPAFSTLRGCLTD----------GQEELILLQEKVKNGKMSMDEA---L 698
                  |.:.:|.....|.:.||:...:|          ..:||..:....||..:|:.:.   :
  Fly   849 ------PLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDELAEIMHDFKNNVLSIRDVEVLV 907

Human   699 EKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHH------------------ 745
            |::||    ::.:    |:..|:.:|.|...|.|.|.:..:  :..|
  Fly   908 ERWKH----RNDV----QQSFREKQDQIDQLRREYERIQEQ--VKSHLKRETPFERIKKFFLRSK 962

Human   746 -PGGKETAHNENK 757
             |||.::..:|.|
  Fly   963 TPGGNDSLLDETK 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BANK1	NP_060405.5	Interaction with ITPR2. /evidence=ECO:0000269|PubMed:11782428	1..154		39/207 (19%)
		TIR_3	28..154	CDD:436583	27/149 (18%)
		DBB	199..328	CDD:464205	30/144 (21%)
		ANK 1	342..371		15/28 (54%)
		ANK 2	378..408		8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..480		17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..514		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..578		7/43 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..625		2/18 (11%)
stumps	NP_731923.2	DBB	423..562	CDD:464205	29/142 (20%)