Protein Alignment PHIP and BDF1

DIOPT Version :10

• Sequence 1: NP_060404.4
• Gene: PHIP / 55023
• HGNCID: 15673
• Length: 1821
• Species: Homo sapiens
• Sequence 2: NP_013503.1
• Gene: BDF1 / 851115
• SGDID: S000004391
• Length: 686
• Species: Saccharomyces cerevisiae
• Alignment Length: 601
• Identity: 125/601 - (20%)
• Similarity: 213/601 - (35%)
• Gaps: 159/601 - (26%)

Human  1130 PEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVD--LQA 1192
            |:|...:.| .:.:..:|...|:       |:.::...::| |..:..|..|..|:.|||  ...
Yeast   128 PKEPAPAPP-PEPDMNNLPQNPI-------PKHQQKHALLA-IKAVKRLKDARPFLQPVDPVKLD 183

Human  1193 YPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAK-----FV 1252
            .|.|...:..|.|||||:::|....|.....:..:...:.:|:..||.|.:.|.:.|:     |.
Yeast   184 IPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFE 248

Human  1253 TDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTR--------KRKDHQPRRR- 1308
            ..:|....||             ...|::.........|.|....|        ||..|.|:.:
Yeast   249 KHMLNMPAKD-------------APPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKD 300

Human  1309 ----LRNRAQSYDIQAWKKQCEELLNLIFQCEDSE---PFRQPVD--LLEYPDYRDIIDTPMDFA 1364
                ...:.:|..:|...|.|:.:|..:...:.:.   ||.:|||  .:..|.|.|.:..|||..
Yeast   301 IYPYESKKPKSKRLQQAMKFCQSVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLG 365

Human  1365 TVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFE-------------- 1415
            |:.:.|....|::..:..:||||:|.|...:.|. .:.:..|..||...|.
Yeast   366 TIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPD-GTIVNMMGHRLEEVFNSKWADRPNLDDYDS 429

Human  1416 --------------------------------EHISSVLSDYKSALRFHKRNTI----------- 1437
                                            :::...|:..|..|:..|:..:
Yeast   430 DEDSRTQGDYDDYESEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKIRKERRLAR 494

Human  1438 -TKRRKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTESS 1501
             :|:|.||::..|.|.:|:|...|.|       |::..|.......|.|..|.|      ...:|
Yeast   495 GSKKRGKRSKGRSGSKNASSKGRRDK-------KNKLKTVVTYDMKRIITERIN------DLPTS 546

Human  1502 SVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTIL----------ENSVKHSKALN 1556
            .:.|      .:|.:....|:.|...:   .:.:...:...|||          |:|...|..|:
Yeast   547 KLER------AIDIIKKSMPNISEDDE---VELDLDTLDNHTILTLYNTFFRQYESSSGASNGLD 602

Human  1557 -----TLSSPGQSSFSHGTRNNSAKENMEKEKP---VKRKMKSSVLPKASTLSKSSAVIEQGDCK 1613
                 |..:...|..|.|:|...:|...::|:.   .|.|.|.::|..||.||::.:
Yeast   603 GTSGVTRDASSLSPTSAGSRKRRSKALSQEEQSRQIEKIKNKLAILDSASPLSQNGS-------- 659

Human  1614 NNALVPGTIQVNGHGG 1629
                 ||.||...|.|
Yeast   660 -----PGQIQSAAHNG 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHIP	NP_060404.4	WD40	118..497	CDD:441893
		WD 1	181..222
		WD40 repeat	186..223	CDD:293791
		WD 2	224..262
		WD40 repeat	229..265	CDD:293791
		WD 3	265..310
		WD40 repeat	270..315	CDD:293791
		WD 4	319..360
		WD40 repeat	323..362	CDD:293791
		WD 5	363..402
		WD40 repeat	368..416	CDD:293791
		WD 6	422..461
		WD 7	464..504
		WD40 repeat	469..494	CDD:293791
		WD 8	512..551
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..689
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	751..927
		Mediates interaction with IRS1. /evidence=ECO:0000250	924..1129
		Bromo_WDR9_I_like	1148..1263	CDD:99958	29/121 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1280..1310		7/42 (17%)
		Bromo_WDR9_II	1316..1434	CDD:99928	32/168 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1435..1507		18/83 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1597		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1623..1646		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1784
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	60/266 (23%)
		Bromodomain	<339..417	CDD:445827	25/78 (32%)
		PTZ00108	<386..647	CDD:240271	52/283 (18%)
		BET	527..589	CDD:435704	12/76 (16%)