Protein Alignment PHIP and phip

DIOPT Version :10

• Sequence 1: NP_060404.4
• Gene: PHIP / 55023
• HGNCID: 15673
• Length: 1821
• Species: Homo sapiens
• Sequence 2: XP_021329407.2
• Gene: phip / 569727
• ZFINID: ZDB-GENE-050208-261
• Length: 1807
• Species: Danio rerio
• Alignment Length: 1882
• Identity: 1255/1882 - (66%)
• Similarity: 1456/1882 - (77%)
• Gaps: 136/1882 - (7%)

Human     1 MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVK 65
            |:.|||.:::|:||||||||||||.||||.||:.|||||.:|||||:|.||||||||.:|:||||
Zfish     1 MAAERKHVAQLKSELYFLIARFLEAGPCQDAAETLIREVQQKELLPKRIDWTGKEHPGSYENLVK 65

Human    66 YYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHC 130
            .|||::||||||:|.|:.||||:|:|.|||||.:|||.||||:||||||||||||||||||||||
Zfish    66 LYRHISPDHLLQVCERVSPLLEREVPASVPGVNSLLGTGRQSVLRTNKSCKHVVWKGSALAALHC 130

Human   131 GRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTG 195
            |||||.||.:||||:||:|:.||:|||.|||.:||||||||||||||||||||||||||||||||
Zfish   131 GRPPEPPVIFGSPPNIAETIHSRRLNGSYRLGQLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTG 195

Human   196 RRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPL 260
            ||||||||||||||||||||.||||||||||||||||||||||::||||||||||||||:|||||
Zfish   196 RRIFTGSDDCLVKIWATDDGHLLATLRGHAAEISDMAVNYENTLLAAGSCDKMIRVWCLQTCAPL 260

Human   261 AVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMI 325
            |||:||:||||||||||||||:||:|||||||||||||.|||.|||...||:||.||||||||||
Zfish   261 AVLEGHAASITSLQFSPLCSGNKRFLSSTGADGTICFWQWDARTLKFGQRPSKFIERPRPGVQMI 325

Human   326 CSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTAR 390
            |||||||||||||||||||||||:||.||||||||||.|||||||||||::.:||||||||||||
Zfish   326 CSSFSAGGMFLATGSTDHIIRVYYFGGGQPEKISELESHTDKVDSIQFSHSGDRFVSGSRDGTAR 390

Human   391 IWQFKRREWKSILLDMATR-PAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSY 454
            |||.::::|:||||||||: |...|...:|||:||:||||||||.:|||||||.||:||||||||
Zfish   391 IWQLQQQDWRSILLDMATKLPGKYNPPPLEDKVTKLKVTMVAWDCNDNTVITAANNLTLKVWNSY 455

Human   455 TGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFD 519
            ||.|||||||||||||||||||||.|||||||||||.||||||||||||||||||||||||||||
Zfish   456 TGNLIHVLMGHEDEVFVLEPHPFDSRVLFSAGHDGNAIVWDLARGVKIRSYFNMIEGQGHGAVFD 520

Human   520 CKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHL 584
            ||||||||||||||||||||||||||||:|||||||||||:|||||||||:||||||||||||||
Zfish   521 CKCSPDGQHFACTDSHGHLLIFGFGSSSRYDKIADQMFFHTDYRPLIRDAHNFVLDEQTQQAPHL 585

Human   585 MPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQR 649
            |||||||||||||||.|:||||||||||||||||||||:||||||||:||||.:..|||||||||
Zfish   586 MPPPFLVDVDGNPHPPRFQRLVPGRENCREEQLIPQMGLTSSGLNQVVSQQAAEGSSPLDSMIQR 650

Human   650 LQQEQDLRRSGEAVISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATER 714
            ||||||.|      :.:.||.:|||:||.:||.||||||||||||||||||||||||||||||||
Zfish   651 LQQEQDQR------LGSDSRANRGSVSSPTEVTSPPNVGLRRSGQIEGVRQMHSNAPRSEIATER 709

Human   715 DLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRK--HLTVPKENKIPTVSKNHAH 777
            |||||||||:|||||..:|.:||.||||||||||..||||.:|:  |....:||:       ||.
Zfish   710 DLVAWSRRVLVPELSLAIACKQEIWRTAKGEEEINIYRSERRRRSLHSQYHRENR-------HAI 767

Human   778 EHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSD-EGEVVAVSGGTSE---EEERA 838
            |:..:  |.::.|.|||||.||.|:|||.|.||..|...|:|: |.||...|..:|:   ||:..
Zfish   768 ENAAE--EGRRHQGNQHNYHTRLAVEETSRQSEPNEEEHSASEGETEVRPPSRESSDEEREEKEP 830

Human   839 W-HSDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKV 902
            | ..:.||||||||||||||||||||:||||....|.||..:||.||   :.:|:|..|||::|.
Zfish   831 WPDENSSSSDYSSDYSDWTADAGINLEPPKKTSVKKKKKKNASSSEE---DGEKKKDSKKERRKE 892

Human   903 NEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYF 967
            ..:|||.: ||||||||   ||..:.||...||||||||||.|||||:||||||.||||||||||
Zfish   893 KPDKDGAL-PKKKKPKE---KRKRIPELQNQGLTLEEWLPSNWITDTMPRRCPFTPQMGDEVYYF 953

Human   968 RQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGK 1032
            |||||||||||:||||:|||||||||||:|||||||:|||||||||||||||||||||||||:||
Zfish   954 RQGHEAYVEMAKKNKIFSINPKKQPWHKLELREQELLKIVGIKYEVGLPTLCCLKLAFLDPDSGK 1018

Human  1033 LTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPD 1097
            ||||||::|||||||||||||||||||:|:.|.|.||||||:||||||||||||||||.|.||||
Zfish  1019 LTGGSFSIKYHDMPDVIDFLVLRQQFDNARQRNWMIGDRFRAVIDDAWWFGTIESQEPYQAEYPD 1083

Human  1098 SLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRD 1162
            ||||||||||||||||||||||||.:|:..|||||||.|:.||..|.::|:|||||||||:..|:
Zfish  1084 SLFQCYNVCWDNGDTEKMSPWDMEEVPDEVVFPEELGLSMALTQDEQKALLYKPLDGEWGSRTRN 1148

Human  1163 EECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWE 1227
            :|||||:.|||||.|||:|..|..||||||||.|||||||.||||||:||||||||||:||||||
Zfish  1149 QECERIIRGINQLCTLDVAKPFELPVDLQAYPTYCTVVAYVTDLSTIRQRLENRFYRRMSSLMWE 1213

Human  1228 VRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDS-----EDEE 1287
            |||||||.:||||||:.||::||||:||:|.|||||:|.:||||||||||...|||     |||:
Zfish  1214 VRYIEHNAQTFNEPGAFIVRTAKFVSDLMLQFIKDQSCTDIIPLYNSMKKTAFSDSSDDEDEDED 1278

Human  1288 KDADVPGTSTR--KRKDHQPR-RRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLE 1349
            ::.:.|.||.|  ||:..||. |.||::..| |.||||::|.|||.|||||||||||||||||.|
Zfish  1279 EEHEAPCTSNRNKKRQQQQPMLRSLRSKPSS-DPQAWKERCRELLELIFQCEDSEPFRQPVDLDE 1342

Human  1350 YPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFF 1414
            ||||.||:||||||.||...|.||.|::||:|||||||||||||||||||:||||||||||||.|
Zfish  1343 YPDYLDIVDTPMDFGTVLNRLLAGEYDTPMDLCKDVRLIFSNSKAYTPSKKSRIYSMSLRLSALF 1407

Human  1415 EEHISSVLSDYKSALRFHKRNTITKRR-----------KKRNRSSSVSSSAASSPERKKRI---L 1465
            ||||||:|:|:|:|...|... :|::|           |||.|.||..||:|||||||:|:   .
Zfish  1408 EEHISSILTDFKAAQSLHSER-LTRQRLHTDRLTRQSVKKRRRRSSSHSSSASSPERKRRVSSRA 1471

Human  1466 KPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTESSSVV-RTRSNRVVVDPVVTEQPSTSSAAKT 1529
            .|:|.|.:..:. :.|:|:...|....|||||.|:..|. ||||:.....|:....|:.|  |..
Zfish  1472 PPRLDSAAPPTP-AGPSRAPSLRQTHPQINGKAETPVVPGRTRSSARFGSPITDVAPAQS--APP 1533

Human  1530 FITKANASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVL 1594
            .:.::::|     .:|.....||.|   :|...:||....:....|:|:       :||:::.|
Zfish  1534 PLVESSSS-----RVLRTQNPHSTA---VSRENESSAVPPSNGGGARES-------RRKLRTPV- 1582

Human  1595 PKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKPKVEV------------ 1647
                       .:..|...:::....::.:|||......:|:||.|| |:::.
Zfish  1583 -----------KLTPGPVDHSSPPQNSLHLNGHSQVTVGMVRRGRGR-PRLDTQIETPVDTPPPP 1635

Human  1648 --NTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH------PIRDEVLPSSTCNFLSETNNVKED 1704
              .|:|     ||:.||.||    ..|...:|..|      |..|:...|||    ::.:|:.:.
Zfish  1636 LPKTSS-----KKKERKSKK----DTESPRRNFSHEEELMLPTGDDGGASST----AQDSNLSDS 1687

Human  1705 LLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRRSNRKKIDDPID------EEEEFEELKG-- 1761
            ....|.||     |...|:.:|..  .|.|.|.||||:|:..::...      :.||.|...|
Zfish  1688 GEYPKARG-----RPRITKTIDTP--APPSPKTLRRSSRRGNEEITPHTSGSAQSEEPEVYIGED 1745

Human  1762 --SEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW 1821
              |:..|:|||||||||||||:|||||||||||||.|:||||||:|||||||||||||||||
Zfish  1746 GSSKGQMKTRNQGRRTAFYNEEDSEEEQRQLLFEDASITFGTSSKGRVRKLTEKAKANLIGW 1807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHIP	NP_060404.4	WD40	118..497	CDD:441893	322/379 (85%)
		WD 1	181..222		39/40 (98%)
		WD40 repeat	186..223	CDD:293791	35/36 (97%)
		WD 2	224..262		34/37 (92%)
		WD40 repeat	229..265	CDD:293791	32/35 (91%)
		WD 3	265..310		37/44 (84%)
		WD40 repeat	270..315	CDD:293791	36/44 (82%)
		WD 4	319..360		38/40 (95%)
		WD40 repeat	323..362	CDD:293791	36/38 (95%)
		WD 5	363..402		27/38 (71%)
		WD40 repeat	368..416	CDD:293791	33/48 (69%)
		WD 6	422..461		31/38 (82%)
		WD 7	464..504		37/39 (95%)
		WD40 repeat	469..494	CDD:293791	22/24 (92%)
		WD 8	512..551		37/38 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..689		14/30 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	751..927		88/182 (48%)
		Mediates interaction with IRS1. /evidence=ECO:0000250	924..1129		174/204 (85%)
		Bromo_WDR9_I_like	1148..1263	CDD:99958	87/114 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1280..1310		15/37 (41%)
		Bromo_WDR9_II	1316..1434	CDD:99928	90/117 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1435..1507		32/86 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1597		8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1623..1646		9/22 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1784		20/42 (48%)
phip	XP_021329407.2	None