Protein Alignment PHIP and phip

DIOPT Version :10

• Sequence 1: NP_060404.4
• Gene: PHIP / 55023
• HGNCID: 15673
• Length: 1821
• Species: Homo sapiens
• Sequence 2: XP_002936252.2
• Gene: phip / 100158567
• XenbaseID: XB-GENE-988009
• Length: 1835
• Species: Xenopus tropicalis
• Alignment Length: 1854
• Identity: 1416/1854 - (76%)
• Similarity: 1590/1854 - (85%)
• Gaps: 69/1854 - (3%)

Human     9 SELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYRHLAPD 73
            :||:|||||||||||||||||||||||||||.||||||:|.|||||||.||||||||||||||||
 Frog    10 TELKSELYFLIARFLEDGPCQQAAQVLIREVEEKELLPKRVDWTGKEHARTYQNLVKYYRHLAPD 74

Human    74 HLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPV 138
            ||||||.|:|||||:|:|||||||||||||||||||||||||||||||||||||||||||||.|:
 Frog    75 HLLQICQRIGPLLEKEVPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPEPPI 139

Human   139 NYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSD 203
            |||||||||:|.|:|||||.|:.|.||||||||||||||||||||||||||||||||||||||||
 Frog   140 NYGSPPSIANTFFARKLNGNYQFENLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSD 204

Human   204 DCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSA 268
            |||||||:|||||||||||||||||||||||:|||||||||||||||:||||||||||:||||||
 Frog   205 DCLVKIWSTDDGRLLATLRGHAAEISDMAVNFENTMIAAGSCDKMIRIWCLRTCAPLAILQGHSA 269

Human   269 SITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGG 333
            |||||||||||:|||||||||||||||||||||||||||||||.|:||||||||||||||||:||
 Frog   270 SITSLQFSPLCNGSKRYLSSTGADGTICFWLWDAGTLKINPRPTKYTERPRPGVQMICSSFSSGG 334

Human   334 MFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRRE 398
            ||||||||||:||||:|||||||||||||||||||||||||||.|||||||||||||||||||||
 Frog   335 MFLATGSTDHVIRVYYFGSGQPEKISELEFHTDKVDSIQFSNTGNRFVSGSRDGTARIWQFKRRE 399

Human   399 WKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLM 463
            ||||||||.|||.|  :||:||||||:||||||||||||.|||||||||||||||..|||:|:||
 Frog   400 WKSILLDMTTRPTG--VQGVEDKITKLKVTMVAWDRHDNFVITAVNNMTLKVWNSSNGQLVHILM 462

Human   464 GHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQH 528
            ||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   463 GHEDEVFVLESHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQH 527

Human   529 FACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDV 593
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
 Frog   528 FACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDV 592

Human   594 DGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRR 658
            ||||||:|||||||||||||:||||||||:||||:|||||||::.|:|||||:|||||.|||.|.
 Frog   593 DGNPHPTRYQRLVPGRENCRDEQLIPQMGLTSSGMNQVLSQQSDNEVSPLDSLIQRLQLEQDQRM 657

Human   659 SGEAVISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRV 723
            :.:....::||:.|.|:||:||||||||:||||||||||||||||||||||||||||||||||||
 Frog   658 NADTSGGSSSRMGRASVSSSSEVHSPPNIGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRV 722

Human   724 VVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLT--VPKENKIPTVSKNHAHEHFLDLGES 786
            ||||||.||.|:|||||||||||||:.|::|:|:|.:|  ..:|:|: :.||||:.|..||:.:.
 Frog   723 VVPELSTGVLSKQEEWRTAKGEEEIRMYKAEDKKKTITNHAVRESKV-SYSKNHSLELLLDIEDP 786

Human   787 KKQQTNQHNYRTRSALEETPRPSEEIENGSSSSD----EGEVVAVSGGTSEEEER-AWHSDGSSS 846
            |:|.:|.:|||||:|.||...|:|::||  ||||    |.|.||.||.||||:|: .|:||||||
 Frog   787 KRQSSNSYNYRTRAAPEEQAVPTEDVEN--SSSDEAYVESEAVAASGATSEEDEKQEWNSDGSSS 849

Human   847 DYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPIS 911
            ||||||||||||||||||||||:.|::||||||||::||.|:|.||||.|||:||..|:|||..|
 Frog   850 DYSSDYSDWTADAGINLQPPKKILKHRTKKAESSSEDEENSDKFKQKQNKKERKKGMEDKDGSSS 914

Human   912 PKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVE 976
            ||||||||||||||.:|||||.||:|||||||.|||||:||||||||||||||||||||||||||
 Frog   915 PKKKKPKERKQKRLPIGELTEQGLSLEEWLPSAWITDTVPRRCPFVPQMGDEVYYFRQGHEAYVE 979

Human   977 MARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMK 1041
            ||:|||||.||||||||||||||||||||||||||||||||||||||||||.||||||||:||||
 Frog   980 MAKKNKIYRINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDSDTGKLTGGAFTMK 1044

Human  1042 YHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVC 1106
            ||||||||||||||||||:|:.|:|:||||||||||||||||||||||||..:||||||||||||
 Frog  1045 YHDMPDVIDFLVLRQQFDEARRRQWSIGDRFRSVIDDAWWFGTIESQEPLHQDYPDSLFQCYNVC 1109

Human  1107 WDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAG 1171
            ||||||||||||||||||:||||||||||||||.:.|.|||:|:.||||||...|||||:||.|.
 Frog  1110 WDNGDTEKMSPWDMELIPDNAVFPEELGTSVPLIEEEVRSLLYRSLDGEWGCRSRDEECDRITAA 1174

Human  1172 INQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTR 1236
            |||||||||||||||||||||||||.|||||||||||||||||||||||:|||||||||||||||
 Frog  1175 INQLMTLDIASAFVAPVDLQAYPMYSTVVAYPTDLSTIKQRLENRFYRRLSSLMWEVRYIEHNTR 1239

Human  1237 TFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDS-EDEEKDADVPGTSTRKR 1300
            |||||||||.:|||.|.|:||||:|||.||:||||||::|||:|||| |:|||||||||||||||
 Frog  1240 TFNEPGSPIERSAKLVIDVLLHFVKDQCCYDIIPLYNNLKKKLLSDSEEEEEKDADVPGTSTRKR 1304

Human  1301 KDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFAT 1365
            |::||||:||:||.|||:.:||||||||||||||||||||||||||||||.|||:||||||||.|
 Frog  1305 KEYQPRRKLRSRAPSYDLHSWKKQCEELLNLIFQCEDSEPFRQPVDLLEYSDYREIIDTPMDFGT 1369

Human  1366 VRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALR 1430
            |||||||||||:|:||.|||||||||||||||||||:||||||||||||||.:|::|:||:||||
 Frog  1370 VRETLEAGNYETPLELSKDVRLIFSNSKAYTPSKRSKIYSMSLRLSAFFEERMSNILADYRSALR 1434

Human  1431 FHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKPQLKSESST-SAFSTPTRSIPPRHNAAQI 1494
            ||.|||.||.|:|||||||.|||.|||||||:|.:|.|..||::| |..|...|::..:...:.:
 Frog  1435 FHNRNTKTKSRRKRNRSSSSSSSPASSPERKRRYVKQQPNSENTTMSPASVHQRTVAHKVTNSLV 1499

Human  1495 NGK-TESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKT-ILENSVKHSKALNT 1557
            ||| ||.|::.||||.:..|:|.|.|:|:||...|....|:|.|.:.||: ::||:.|..|:.||
 Frog  1500 NGKATEPSTLARTRSYKRQVEPAVPEKPTTSGTPKQLTAKSNHSTVAGKSAMIENAAKLLKSQNT 1564

Human  1558 LSSPGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTI 1622
              ||.|:| :|..:||..||.:||:||:||:||:           ||.:..:.|.|.......:|
 Frog  1565 --SPNQAS-NHLIKNNVPKEKLEKDKPLKRRMKA-----------SSNMALRADRKEILHQASSI 1615

Human  1623 QVNGHGGQPSK-LVKRGPGRKPKVEVNTNSG-------EIIHKKRGRKPKKLQYAKPEDLEQNNV 1679
            |||||..:|.| :||..|||||||.:|.::.       :::.||||||||   |.:.|.|:..:.
 Frog  1616 QVNGHSSEPLKPIVKGRPGRKPKVILNNSNNYETITVVQVVPKKRGRKPK---YPRNEALQSVSQ 1677

Human  1680 HP---------IRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPA-- 1733
            .|         |:::. .||:||..:......|:.:.||.| ||||  |:||:......::||
 Frog  1678 KPPNSVVETGKIKEQP-ASSSCNSHAAPCEKTENEVPKKRR-GRKP--KVKTEPTSLVAVIPAPS 1738

Human  1734 --------SVKVLRRSNRKKIDDPIDEEEEF---EELKGSEPHMRTRNQGRRTAFYNEDDSEEEQ 1787
                    :||:..||..||.|.  .|.|..   |::..:|..|||||||||||||||:||||||
 Frog  1739 AHELKREETVKIQTRSKCKKSDQ--SEGESLTVSEDINNTEIQMRTRNQGRRTAFYNEEDSEEEQ 1801

Human  1788 RQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW 1821
            ||||||||||||||||||||||||||||||||||
 Frog  1802 RQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW 1835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHIP	NP_060404.4	WD40	118..497	CDD:441893	345/378 (91%)
		WD 1	181..222		39/40 (98%)
		WD40 repeat	186..223	CDD:293791	35/36 (97%)
		WD 2	224..262		35/37 (95%)
		WD40 repeat	229..265	CDD:293791	32/35 (91%)
		WD 3	265..310		43/44 (98%)
		WD40 repeat	270..315	CDD:293791	42/44 (95%)
		WD 4	319..360		37/40 (93%)
		WD40 repeat	323..362	CDD:293791	35/38 (92%)
		WD 5	363..402		37/38 (97%)
		WD40 repeat	368..416	CDD:293791	42/47 (89%)
		WD 6	422..461		33/38 (87%)
		WD 7	464..504		38/39 (97%)
		WD40 repeat	469..494	CDD:293791	23/24 (96%)
		WD 8	512..551		38/38 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..689		14/30 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	751..927		114/182 (63%)
		Mediates interaction with IRS1. /evidence=ECO:0000250	924..1129		185/204 (91%)
		Bromo_WDR9_I_like	1148..1263	CDD:99958	97/114 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1280..1310		25/30 (83%)
		Bromo_WDR9_II	1316..1434	CDD:99928	101/117 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1435..1507		38/73 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1597		19/41 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1623..1646		15/23 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1784		20/35 (57%)
phip	XP_002936252.2	WD40	<182..496	CDD:441893	291/315 (92%)
		WD40 repeat	187..224	CDD:293791	35/36 (97%)
		WD40 repeat	230..266	CDD:293791	32/35 (91%)
		WD40 repeat	271..311	CDD:293791	38/39 (97%)
		WD40 repeat	324..363	CDD:293791	35/38 (92%)
		WD40 repeat	369..416	CDD:293791	42/48 (88%)
		WD40 repeat	468..493	CDD:293791	23/24 (96%)
		Bromo_WDR9_I_like	1151..1266	CDD:99958	97/114 (85%)
		Bromodomain	1320..1438	CDD:445827	101/117 (86%)
		DUF612	<1481..1772	CDD:282585	110/313 (35%)