Protein Alignment HERC6 and TOM1

DIOPT Version :10

• Sequence 1: XP_005263140.1
• Gene: HERC6 / 55008
• HGNCID: 26072
• Length: 1034
• Species: Homo sapiens
• Sequence 2: NP_010745.3
• Gene: TOM1 / 852068
• SGDID: S000002865
• Length: 3268
• Species: Saccharomyces cerevisiae
• Alignment Length: 842
• Identity: 183/842 - (21%)
• Similarity: 321/842 - (38%)
• Gaps: 195/842 - (23%)

Human   298 DGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSK--PTHPEALT-ENFDISCLISAEDFVDVQ 359
            :|::.|      |:|..|:......:.||..:.|.:  |:....|| .|..|..|.|..| .|.:
Yeast  2506 EGIIDQ------HSLEKVYNIISSRAMGHAKTTTVRQLPSDCTPLTVANQTIEILQSLID-ADSR 2563

Human   360 VKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFS 424
            :|:.....:.|.:....:..|.:   :.||: .::...:...:..:.|:....|....::.....
Yeast  2564 LKYFLIAEHDNLIVNKANNKSRK---EALPD-KKLRWPLWHLFSLLDRKLITDESVLMDLLTRIL 2624

Human   425 SPACLTASFLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQE 489
            .....|.:.|.....|:               :.|:||..:.|..    ||||::.|.
Yeast  2625 QVCTKTLAVLSTSSNGK---------------ENLSKKFHLPSFD----EDDLMKILS------- 2663

Human   490 ALSVFLLLPECP---------VMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCW---------- 535
                .::|..|.         ::::....:..:..|.|.:..::...:..||...
Yeast  2664 ----IIMLDSCTTRVFQQTLNIIYNLSKLQGCMSIFTKHLVSLAISIMSKLKSALDGLSREVGTI 2724

Human   536 --------AFLQESSL--NPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGM------------- 577
                    ..||:.:|  :...::||.......|:..|.:::..|||.|..:
Yeast  2725 TTGMEINSELLQKFTLPSSDQAKLLKILTTVDFLYTHKRKEEERNVKDLQSLYDKMNGGPVWSSL 2789

Human   578 ---MKELHKVNKAN----------------CRLPENTFNIN-----ELSNLLNFYIDRGRQLFRD 618
               :.:..|....|                ||..:.:.|.|     |.:.||:|...|...||
Yeast  2790 SECLSQFEKSQAINTSATILLPLIESLMVVCRRSDLSQNRNTAVKYEDAKLLDFSKTRVENLF-- 2852

Human   619 NHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKM----------QMSEKKAYMLMHETIL- 672
                            |||            .|:|.|:          .||...|.::.:..:|
Yeast  2853 ----------------FPF------------TDAHKKLLNQMIRSNPKLMSGPFALLVKNPKVLD 2889

Human   673 ----------QKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV--------LVVEFIN 719
                      :.|.:....|:..:.|||.::..|:.|.|       |.|.        |.:.|..
Yeast  2890 FDNKRYFFNAKLKSDNQERPKLPITVRREQVFLDSYRAL-------FFKTNDEIKNSKLEITFKG 2947

Human   720 EICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLS 780
            |...::|||:.|::..:..:|..|:|.:|:........:.|.:.   .||...:|.| ||:.|.:
Yeast  2948 ESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKA 3012

Human   781 LFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWD- 844
            :.:....:..|...:||.:|.:..||:|::.|.|...|||..:|:   :||.|.:...||:..|
Yeast  3013 IRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILE---NDITDIIEETFSVETDD 3074

Human   845 ---QNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPE 906
               ...::||..|..|.|.:.||:|||.|.::|....|||...:.|..|||.:..|:::..|..:
Yeast  3075 YGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQ 3139

Human   907 ELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHAR 971
            ||...|.|..|.|...::.|:.| ..|..:...:..||:|......:|:.|.|.|:||..::...
Yeast  3140 ELELLISGLPDIDVDDWKNNTTY-VNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLN 3203

Human   972 GIQKMEIV-----FRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAIN-NNRGF 1026
            |.:::..|     |.....|...:. |:|.||.|.|:||.|.:.|.:..:|.:||| .:.||
Yeast  3204 GFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGF 3265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC6	XP_005263140.1	ATS1	27..>325	CDD:444065	5/26 (19%)
		HECTc	684..1026	CDD:238033	103/364 (28%)
TOM1	NP_010745.3	DUF908	92..387	CDD:428721
		DUF913	448..>683	CDD:461803
		MSCRAMM_ClfA	<1865..2104	CDD:468110
		UBM	2327..2359	CDD:464159
		UBM	2367..2399	CDD:464159
		HUL4	2385..3268	CDD:227354	183/842 (22%)