DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC6 and herc5.2

DIOPT Version :9

Sequence 1:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	1075	Identity:	334/1075 - (31%)
Similarity:	530/1075 - (49%)	Gaps:	158/1075 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     5 WGADSRE-------LQRRRTAGS-----PGAELLQAASGE---------RHSLLLLTNHRVLSCG 48
            |||..||       .|.|...|.     |.:.:...::|:         :.|:|.|.:.   .|
Zfish     5 WGAQVREGFGLLKPEQVRHGNGGVKSICPKSAVQDMSAGKTFVGFIRDGKVSVLRLRDE---DC- 65

Human    49 DNSRGQLGRRGAQRGELPVVVGGCFVLFPKEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA 113
             |..|:|.:...:|.::..:|                        ||::.::.:...|:|....
Zfish    66 -NQDGKLKQLDLKREKIRSIV------------------------CGEDGAVLLADGGKVLLMD- 104

Human   114 GSEGQLGIGEFKEISFTP-KKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE 177
                          .:|. :.:..|::.|:||::||..||:|||.|.|:|.||:|:||||||.||
Zfish   105 --------------KYTVCRPLKGLDNTKVIQIACGDQHSVALSNDGQLFVWGENAHGQLGLRKE 155

Human   178 FPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLAL---SGRNVPVQSNKP 239
            .....|||.::||.|||:||::|||.|||.|||.|..|||||||||||.|   :.|.||.
Zfish   156 QALIQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFVPT----- 215

Human   240 LSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDG-LVSQ 303
             .|.:|.....|.||||..|||.|::.|.|||||....||||::...::..|:||..:.| .|||
Zfish   216 -IVKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLVAELWGSKVSQ 279

Human   304 IDCGSYHTLAYVHTTGQVVSFG------HGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKH 362
            :.||.:|||..|..|.::.|||      .|..:..|.:.|..:....|.:|..:.|..:..: ||
Zfish   280 VTCGRHHTLVLVALTNRIYSFGCGMQGQLGNGEQVKQSVPLPVLLPTDCNCEFTMEKIIAGE-KH 343

Human   363 IFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPA 427
            .||..:.|     ....||:........|..::..|.::|::   .|......|.||:.:|||..
Zfish   344 SFALFFKN-----PGNESTKPKSSMNGGILTLNDRMIDRWVS---GSYPWPTVKKEIKKVFSSAV 400

Human   428 CLTASFLKKRGTGETTSID-VDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEAL 491
            ||..||||       .|:| .|.::...:|.|||..|.:.|.:...::..||.:|.....|:|:|
Zfish   401 CLNGSFLK-------PSLDEQDFDLVGKSFSKLTDNEKVISEVVKVIQQTLLPSLNPKPAHEESL 458

Human   492 SVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQML--KAAI 554
            .::|||||.....:......|....|..:.:::..:.::|:..|:.|.:..|..|:::.  ::|.
Zfish   459 RLYLLLPELIKGLEQYQRSELNKALASKILQLNSAAREMLEMFWSKLPDDWLKSLVKLFHKESAD 523

Human   555 ISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCR-LPENTFNINELSNLLNF----------- 607
            :...:.....:.|..:::.||.:::..:||..:..| :..:.|.|.|:|:|||.
Zfish   524 LIDYMSVCAMDSDLKHLQNLLRILQMAYKVCCSTHRDITISDFIIYEISDLLNALQATIDDLADW 588

Human   608 --YIDRGRQL-FRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHE 669
              ::|....: .||..:...|     |...|||:.:..||..:.   :|::::|
Zfish   589 DPFVDYVYMMKLRDYFIKTLE-----ILVKFPFVADYASKRGIF---NHLEIKM----------- 634

Human   670 TILQKKDEFPPSPRF-ILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFF 733
             |.:..:.|..:..| :|.:.|..|:.|.|:.|.| ....|..:..|.||.|...:..|:|:|||
Zfish   635 -IRRSSNRFLGNATFNVLHINRESLLMDTLKYLRQ-NTHSFSHLSRVAFIGEDGIDMRGLSAEFF 697

Human   734 HCMFEEMTKPEYGMF-MYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYK 797
            ..:.:...|.:..:. ::|  .|.:||........|.::..|::||::|:|.:..|:.|||||:|
Zfish   698 SLISKSFLKWDKKILEVHP--SSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPLALFK 760

Human   798 KLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSI--HWDQNDVDLIPNGISIPVD 860
            |||.|||||:||:||||...:||:.:|.: .:::.|.|.:.|::  |      :|:|||..|.|:
Zfish   761 KLLQQKPSLDDLEELSPVEARSLKNLLKE-DEEVVDLLFLDFTVKGH------ELVPNGSQIQVN 818

Human   861 QTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQ 925
            :.|::.||..|:|::||.|||..:|:|.|||.:.|..:....|:||||...:.|:..|:||:|:|
Zfish   819 KVNRQKYVDLYVDFVFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKEFQQ 883

Human   926 NSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFR---CPETFS 987
            ::.|| |...|...|:.||..|.:|:.:.|||||.||.|.:|:.|.|..|..|...   ||:
Zfish   884 SASYE-GCSASDELIKNFWTVFFELSEEHKKKFLMFLYGTERVPAGGFSKRRIKISTRDCPD--- 944

Human   988 ERDH-PTSITCHNILSLPKYSTMERMEEALQVAIN 1021
            ..|| |.:.||...|.||||:.:..:...|..|||
Zfish   945 PDDHLPKAQTCFGRLVLPKYTDINTLRNKLTHAIN 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274	6/35 (17%)
		RCC1_2	89..118	CDD:290274	4/28 (14%)
		RCC1	105..155	CDD:278826	11/50 (22%)
		RCC1	158..208	CDD:278826	30/49 (61%)
		RCC1	215..263	CDD:278826	25/50 (50%)
		RCC1_2	250..279	CDD:290274	15/28 (54%)
		RCC1	266..313	CDD:278826	21/47 (45%)
		HECTc	684..1026	CDD:238033	128/346 (37%)
		HECTc	711..1026	CDD:214523	119/318 (37%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274	16/28 (57%)
		RCC1	136..186	CDD:278826	30/49 (61%)
		RCC1	189..238	CDD:278826	26/54 (48%)
		RCC1	242..290	CDD:278826	22/47 (47%)
		RCC1	296..347	CDD:278826	12/51 (24%)
		HECTc	649..985	CDD:294058	127/345 (37%)
		HECTc	678..984	CDD:214523	119/315 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	9	9.390