Protein Alignment HERC6 and herc-1

DIOPT Version :10

• Sequence 1: XP_005263140.1
• Gene: HERC6 / 55008
• HGNCID: 26072
• Length: 1034
• Species: Homo sapiens
• Sequence 2: NP_490834.1
• Gene: herc-1 / 171700
• WormBaseID: WBGene00021685
• Length: 1019
• Species: Caenorhabditis elegans
• Alignment Length: 1089
• Identity: 327/1089 - (30%)
• Similarity: 510/1089 - (46%)
• Gaps: 180/1089 - (16%)

Human    16 RTAGSP----GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGCFVLF 76
            |..|:|    |..:.....||:|::.|..:.::.|.|.|..|||||  ..|.|      |.|.::
 Worm    30 RIIGAPNDMDGTAVTSVTCGEQHTVFLTKDGKMWSVGSNMDGQLGR--GSRTE------GSFSIY 86

Human    77 PKEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISF----TPKKIMTL 137
               |:....:..:..:|.|:.|:::|...|||||||:...||||:    |..|    ||:::..:
 Worm    87 ---PVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGM----ESKFTWQGTPRRVQEI 144

Human   138 NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 202
            ||  |:||:.|..|.:||.:..:||.||:.:.|:        ....|:.|..|.|:|:.:|.||.
 Worm   145 ND--IVQVASGSNHCIALDEGGRVFVWGEQADGR--------CIHRPEPVEQLSGVPIVRVLAGA 199

Human   203 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDG 267
            .|..|||..|..|.||.|::|:|.:.... |..|.:  .|..:..||||..:|||.||.:||..|
 Worm   200 RHCLALSASGAVFTWGQNNSGELGIDDLR-PQTSVQ--HVHQMDGLGVVEAACGDNHTVLLTHCG 261

Human   268 KVFTFGDNRSGQLGYSPTPEKR-GPQLVERIDGL-VSQIDCGSYHTLAY---------VHTTGQV 321
            :.|:||.:..||.|:....||| .|..|..:.|. |::|..|:.||:|.         ::::||:
 Worm   262 RTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAPYPFGLNSSGQL 326

Human   322 VSFGHGPSDT-SKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPG 385
               |:|...| |.|..    |:..|             .|..:|||.:..|.        .|:.|
 Worm   327 ---GNGKIMTQSTPRK----TDELD-------------HVTGVFAGYHQTFF--------VRSSG 363

Human   386 KTLPEISRISQSMAEKWIAVKRRSTEHEMAK------------SEIRMIFSSPACLTASFLKK-- 436
             |:.:...:..|...:: .:|   .:||..|            |.|..:|||.|.:..|||.|
 Worm   364 -TIEQNEIVGPSCPMQY-PIK---LDHESLKKLLDEGDALEVMSLIESVFSSLASMNMSFLYKDE 423

Human   437 ----------RGTGETTSIDVD------------------LEMARDTFKKLTKKEWISSMITTCL 473
                      |..|    ||:|                  :|:..|:. |:..:||
 Worm   424 RRYNVGFCFERSHG----IDMDQVMEAFMLFDEYPMKRQYMELIVDSL-KIAFQEW--------- 474

Human   474 EDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKN---WKNLVVPFAKAVCEMSKQSLQVLKKCW 535
             .:.|:.:.|       |.|.|:||..|:..::.|   .||:..||..|:|.::......|:|.|
 Worm   475 -SENLKGIEC-------LRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWW 531

Human   536 AFLQESSLNPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINE 600
            ..|.......::.:.|.| |..:|...|..:| |: |.:| :|::|..:||....:|..||.|:|
 Worm   532 TQLSTRHFRRMVTVFKTA-IKAMLKAKKGPRD-CH-KFIL-IMQKLSLINKTYHIIPLETFYIDE 592

Human   601 LSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKA-Y 664
            |:..::..::...:|.|.:   |.:|... .::.|||:.|.::|.:|:..::.:...:..:.: :
 Worm   593 LNTSVDLKLEYVLELTRQD---PNKTELD-YWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSLF 653

Human   665 MLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVS 729
            ...|.||:.:      .|...|.|||..:|.|.:.|::....:|..|.|.|....|...::|||.
 Worm   654 NTAHGTIIFE------LPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVR 712

Human   730 SEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKP--EKKRYFLFGMLCGLSLFNLNVANLPFP 792
            .|||..:..::.:.:||||...|....:||...|..  :::::...|.|.|||::|.::...|||
 Worm   713 KEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFP 777

Human   793 LALYKKLLDQKPSLEDLKELSPRLGKSLQEVL----DDAADDIGDALCIRFSIHWDQNDVDLIPN 853
            |||||.|||..|.||||.||||..||.|:.:|    ||..|..|...||.|:|..:.:..:|:..
 Worm   778 LALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSG 842

Human   854 GISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEE----FQRGFYRVCEKEILRHFYPEELMTAIIG 914
            |...||...|:.:||..|:.:...:.......:    |::||........||.|.|.||...|:|
 Worm   843 GTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVG 907

Human   915 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIV 979
            |.:|||.:|.....|...|..||||||.|||||..||.||::|||.||||..|:...|.:::...
 Worm   908 NENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAA 972

Human   980 FR--CPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
            .:  .||:.     |.:.||.|:|.||..:....:...|:::|.:..||
 Worm   973 IQPSAPESL-----PVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGF 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC6	XP_005263140.1	ATS1	27..>325	CDD:444065	104/312 (33%)
		HECTc	684..1026	CDD:238033	125/353 (35%)
herc-1	NP_490834.1	RCC1	7..56	CDD:395335	7/25 (28%)
		ATS1	44..365	CDD:444065	118/377 (31%)
		HECTc	667..1016	CDD:238033	125/353 (35%)