DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC6 and herc-1

DIOPT Version :9

Sequence 1:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	1089	Identity:	327/1089 - (30%)
Similarity:	510/1089 - (46%)	Gaps:	180/1089 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    16 RTAGSP----GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGCFVLF 76
            |..|:|    |..:.....||:|::.|..:.::.|.|.|..|||||  ..|.|      |.|.::
Worm    30 RIIGAPNDMDGTAVTSVTCGEQHTVFLTKDGKMWSVGSNMDGQLGR--GSRTE------GSFSIY 86

Human    77 PKEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISF----TPKKIMTL 137
               |:....:..:..:|.|:.|:::|...|||||||:...||||:    |..|    ||:::..:
Worm    87 ---PVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGM----ESKFTWQGTPRRVQEI 144

Human   138 NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 202
            ||  |:||:.|..|.:||.:..:||.||:.:.|:        ....|:.|..|.|:|:.:|.||.
Worm   145 ND--IVQVASGSNHCIALDEGGRVFVWGEQADGR--------CIHRPEPVEQLSGVPIVRVLAGA 199

Human   203 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDG 267
            .|..|||..|..|.||.|::|:|.:.... |..|.:  .|..:..||||..:|||.||.:||..|
Worm   200 RHCLALSASGAVFTWGQNNSGELGIDDLR-PQTSVQ--HVHQMDGLGVVEAACGDNHTVLLTHCG 261

Human   268 KVFTFGDNRSGQLGYSPTPEKR-GPQLVERIDGL-VSQIDCGSYHTLAY---------VHTTGQV 321
            :.|:||.:..||.|:....||| .|..|..:.|. |::|..|:.||:|.         ::::||:
Worm   262 RTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAPYPFGLNSSGQL 326

Human   322 VSFGHGPSDT-SKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPG 385
               |:|...| |.|..    |:..|             .|..:|||.:..|.        .|:.|
Worm   327 ---GNGKIMTQSTPRK----TDELD-------------HVTGVFAGYHQTFF--------VRSSG 363

Human   386 KTLPEISRISQSMAEKWIAVKRRSTEHEMAK------------SEIRMIFSSPACLTASFLKK-- 436
             |:.:...:..|...:: .:|   .:||..|            |.|..:|||.|.:..|||.|
Worm   364 -TIEQNEIVGPSCPMQY-PIK---LDHESLKKLLDEGDALEVMSLIESVFSSLASMNMSFLYKDE 423

Human   437 ----------RGTGETTSIDVD------------------LEMARDTFKKLTKKEWISSMITTCL 473
                      |..|    ||:|                  :|:..|:. |:..:||
Worm   424 RRYNVGFCFERSHG----IDMDQVMEAFMLFDEYPMKRQYMELIVDSL-KIAFQEW--------- 474

Human   474 EDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKN---WKNLVVPFAKAVCEMSKQSLQVLKKCW 535
             .:.|:.:.|       |.|.|:||..|:..::.|   .||:..||..|:|.::......|:|.|
Worm   475 -SENLKGIEC-------LRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWW 531

Human   536 AFLQESSLNPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINE 600
            ..|.......::.:.|.| |..:|...|..:| |: |.:| :|::|..:||....:|..||.|:|
Worm   532 TQLSTRHFRRMVTVFKTA-IKAMLKAKKGPRD-CH-KFIL-IMQKLSLINKTYHIIPLETFYIDE 592

Human   601 LSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKA-Y 664
            |:..::..::...:|.|.:   |.:|... .::.|||:.|.::|.:|:..::.:...:..:.: :
Worm   593 LNTSVDLKLEYVLELTRQD---PNKTELD-YWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSLF 653

Human   665 MLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVS 729
            ...|.||:.:      .|...|.|||..:|.|.:.|::....:|..|.|.|....|...::|||.
Worm   654 NTAHGTIIFE------LPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVR 712

Human   730 SEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKP--EKKRYFLFGMLCGLSLFNLNVANLPFP 792
            .|||..:..::.:.:||||...|....:||...|..  :::::...|.|.|||::|.::...|||
Worm   713 KEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFP 777

Human   793 LALYKKLLDQKPSLEDLKELSPRLGKSLQEVL----DDAADDIGDALCIRFSIHWDQNDVDLIPN 853
            |||||.|||..|.||||.||||..||.|:.:|    ||..|..|...||.|:|..:.:..:|:..
Worm   778 LALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSG 842

Human   854 GISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEE----FQRGFYRVCEKEILRHFYPEELMTAIIG 914
            |...||...|:.:||..|:.:...:.......:    |::||........||.|.|.||...|:|
Worm   843 GTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVG 907

Human   915 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIV 979
            |.:|||.:|.....|...|..||||||.|||||..||.||::|||.||||..|:...|.:::...
Worm   908 NENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAA 972

Human   980 FR--CPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
            .:  .||:.     |.:.||.|:|.||..:....:...|:::|.:..||
Worm   973 IQPSAPESL-----PVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGF 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274	7/26 (27%)
		RCC1_2	89..118	CDD:290274	11/28 (39%)
		RCC1	105..155	CDD:278826	22/53 (42%)
		RCC1	158..208	CDD:278826	14/49 (29%)
		RCC1	215..263	CDD:278826	18/47 (38%)
		RCC1_2	250..279	CDD:290274	13/28 (46%)
		RCC1	266..313	CDD:278826	18/48 (38%)
		HECTc	684..1026	CDD:238033	125/353 (35%)
		HECTc	711..1026	CDD:214523	117/326 (36%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511	120/384 (31%)
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	125/353 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	548	1.000	Inparanoid score	I676
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		otm16541
orthoMCL	1	0.900	-	-		OOG6_103327
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780