Protein Alignment psen2 and Psn

DIOPT Version :9

• Sequence 1: NP_001017181.1
• Gene: psen2 / 549935
• XenbaseID: XB-GENE-854877
• Length: 451
• Species: Xenopus tropicalis
• Sequence 2: NP_001262111.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 545
• Identity: 244/545 - (44%)
• Similarity: 324/545 - (59%)
• Gaps: 113/545 - (20%)

 Frog     6 NSSDSEDDECNERTSLITSQSPPLPSYQDGLQASGGSESSDPMKTQTDTQVIEDVPN-------- 62
            :|..:.:|:.|..:.:..::....|..:...:.:.||.:.|    |.|..::. |||
  Fly    11 SSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQD----QPDAAILA-VPNVVMREPCG 70

 Frog    63 ---GRTSGADAYNSDAAMENEEEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTEKDGQL 124
               .|.:|....:........|||..|||||:|||.|||||:|||:||||||.|:|||...|..|
  Fly    71 SRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYL 135

 Frog   125 IYTPFSEDTTSVGQRLLNSVLNTLIMISVIIVMTIFLVLLYKYRCYKFIHGWLILSSLMLLFMFT 189
            :||||.|.:.....:..:::.|:||::||::|||..|::|||.|||:.|||||||||.||||:||
  Fly   136 LYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFT 200

 Frog   190 YIYLSEVFKTYNIAMDYPTLFMVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPE 254
            |:||.|:.:.|||.|||||..:::||||.|||:.|||:|||:|||.|||.::|||||||||||||
  Fly   201 YLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPE 265

 Frog   255 WSAWVILGAISVYDLLAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMADSATADGRM 319
            |:||.:|.|||::||:|||.|:||||:||||||||||.|||||||||.:|:  .:.::.|.
  Fly   266 WTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVY--ALVNTVTP---- 324

 Frog   320 NQQVQRTDRNAPNHTNSS----------------------------------------------- 337
             ||.|.|..::|:.:||:
  Fly   325 -QQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLV 388

 Frog   338 -----------------------QEDAAETSVQTQSNVSSE------------------DPDEER 361
                                   .|..|...::.||..|..                  |..|||
  Fly   389 TFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEER 453

 Frog   362 GVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFG 426
            |:||||||||||||||||  |::.|||.||:||||||||||||||||||:::|||||||||||||
  Fly   454 GIKLGLGDFIFYSVLVGK--ASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFG 516

 Frog   427 LIFYFSTDNIVRPFMDTLASHQMYI 451
            |||.|:|..:|:|||:.|::.|::|
  Fly   517 LIFCFATSAVVKPFMEDLSAKQVFI 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
psen2	NP_001017181.1	Presenilin	87..441	CDD:279427	221/441 (50%)
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	221/441 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H386
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1669
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm48735
Panther	1	1.100	-	-	LDO	PTHR10202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2736
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110