Protein Alignment psen2 and Psn

DIOPT Version :10

• Sequence 1: NP_001017181.1
• Gene: psen2 / 549935
• XenbaseID: XB-GENE-854877
• Length: 451
• Species: Xenopus tropicalis
• Sequence 2: NP_524184.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 545
• Identity: 244/545 - (44%)
• Similarity: 324/545 - (59%)
• Gaps: 113/545 - (20%)

 Frog     6 NSSDSEDDECNERTSLITSQSPPLPSYQDGLQASGGSESSDPMKTQTDTQVIEDVPN-------- 62
            :|..:.:|:.|..:.:..::....|..:...:.:.||.:.|    |.|..::. |||
  Fly    11 SSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQD----QPDAAILA-VPNVVMREPCG 70

 Frog    63 ---GRTSGADAYNSDAAMENEEEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTEKDGQL 124
               .|.:|....:........|||..|||||:|||.|||||:|||:||||||.|:|||...|..|
  Fly    71 SRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYL 135

 Frog   125 IYTPFSEDTTSVGQRLLNSVLNTLIMISVIIVMTIFLVLLYKYRCYKFIHGWLILSSLMLLFMFT 189
            :||||.|.:.....:..:::.|:||::||::|||..|::|||.|||:.|||||||||.||||:||
  Fly   136 LYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFT 200

 Frog   190 YIYLSEVFKTYNIAMDYPTLFMVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPE 254
            |:||.|:.:.|||.|||||..:::||||.|||:.|||:|||:|||.|||.::|||||||||||||
  Fly   201 YLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPE 265

 Frog   255 WSAWVILGAISVYDLLAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMADSATADGRM 319
            |:||.:|.|||::||:|||.|:||||:||||||||||.|||||||||.:|:  .:.::.|.
  Fly   266 WTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVY--ALVNTVTP---- 324

 Frog   320 NQQVQRTDRNAPNHTNSS----------------------------------------------- 337
             ||.|.|..::|:.:||:
  Fly   325 -QQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLV 388

 Frog   338 -----------------------QEDAAETSVQTQSNVSSE------------------DPDEER 361
                                   .|..|...::.||..|..                  |..|||
  Fly   389 TFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEER 453

 Frog   362 GVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFG 426
            |:||||||||||||||||  |::.|||.||:||||||||||||||||||:::|||||||||||||
  Fly   454 GIKLGLGDFIFYSVLVGK--ASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFG 516

 Frog   427 LIFYFSTDNIVRPFMDTLASHQMYI 451
            |||.|:|..:|:|||:.|::.|::|
  Fly   517 LIFCFATSAVVKPFMEDLSAKQVFI 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
psen2	NP_001017181.1	Presenilin	87..441	CDD:460052	221/441 (50%)
Psn	NP_524184.1	Presenilin	98..531	CDD:460052	221/441 (50%)