Protein Alignment INTS11 and YSH1

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_013379.1
• Gene: YSH1 / 850983
• SGDID: S000004267
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 678
• Identity: 203/678 - (29%)
• Similarity: 321/678 - (47%)
• Gaps: 139/678 - (20%)

Human    63 FEWLAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFP-----DFSYITQNGRLTDFLD 122
            |::.:.||: .:|||||.::...||.||||.|:|..:......|     |.|.:          |
Yeast     9 FKFFSLGGS-NEVGRSCHILQYKGKTVMLDAGIHPAYQGLASLPFYDEFDLSKV----------D 62

Human   123 CVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKI--------AVDKKGEAN 179
            .::||||||||..:|||..:...:.|.::|||||:||...||.|:.::        ::..|.| .
Yeast    63 ILLISHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIYRWLLRDFVRVTSIGSSSSSMGTKDE-G 126

Human   180 FFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPD 244
            .|:.:.:.|...|:..|..|.||.|:. ::..|::||||||||||||::....|::||||:...|
Yeast   127 LFSDEDLVDSFDKIETVDYHSTVDVNG-IKFTAFHAGHVLGAAMFQIEIAGLRVLFTGDYSREVD 190

Human   245 RHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELC 309
            |||.:|.:.....|:||.|||:.|...:.:..|||...:.:|.||.|||:||:||||||||||:.
Yeast   191 RHLNSAEVPPLSSNVLIVESTFGTATHEPRLNRERKLTQLIHSTVMRGGRVLLPVFALGRAQEIM 255

Human   310 ILLETFW-----ERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTF--VQRNMFEFKHIKA 367
            ::|:.:|     |....:|||::::.|.:|....::.::...|..|||.|  .|.|.|.||:| :
Yeast   256 LILDEYWSQHADELGGGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPFIFKNI-S 319

Human   368 FDRAFAD--NPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKL 430
            :.|...|  :.||.|:.|:||||.:|.|..:..:|...:||:|::.||.::||:...|:.....:
Yeast   320 YLRNLEDFQDFGPSVMLASPGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMAKFIMLEPDTI 384

Human   431 EMEGRQVLEV--KMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQEL-- 491
            .......:.:  :.|||.:||:||.|.:..::.:.:....:::||||||..|..||..:....
Yeast   385 PSINNPEITIPRRCQVEEISFAAHVDFQENLEFIEKISAPNIILVHGEANPMGRLKSALLSNFAS 449

Human   492 ------RVNCYMPANGETVTLPTSPSIPVGISLG------------LLKREMA------------ 526
                  .|:.:.|.|...|.|... .:.|..::|            .:|.|:|
Yeast   450 LKGTDNEVHVFNPRNCVEVDLEFQ-GVKVAKAVGNIVNEIYKEENVEIKEEIAAKIEPIKEENED 513

Human   527 -------QGLLPEAK-KPRLLHGTLIMKDSNFRLVSSEQALKELGLAEH-------------QLR 570
                   :||:.|.: |..::.|.|:..|.||.|    ..|....|.||             .:|
Yeast   514 NLDSQAEKGLVDEEEHKDIVVSGILVSDDKNFEL----DFLSLSDLREHHPDLSTTILRERQSVR 574

Human   571 FTCRVHLHDTRKEQETALRVYSHL------KSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGT 629
            ..|:..|            :|.|:      ..||:|       |..||.:...::..:......|
Yeast   575 VNCKKEL------------IYWHILQMFGEAEVLQD-------DDRVTNQEPKVKEESKDNLTNT 620

Human   630 -KVLL----------------VSWTYQD 640
             |::|                |.|| ||
Yeast   621 GKLILQIMGDIKLTIVNTLAVVEWT-QD 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	163/468 (35%)
		INTS11-like_MBL-fold	70..264	CDD:293849	76/206 (37%)
YSH1	NP_013379.1	CPSF3-like_MBL-fold	9..210	CDD:293850	78/213 (37%)
		YSH1	14..432	CDD:440849	153/431 (35%)
		CPSF73-100_C	533..777	CDD:463330	29/139 (21%)