Protein Alignment INTS11 and Ints11

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_082296.1
• Gene: Ints11 / 71957
• MGIID: 1919207
• Length: 600
• Species: Mus musculus
• Alignment Length: 660
• Identity: 583/660 - (88%)
• Similarity: 592/660 - (89%)
• Gaps: 60/660 - (9%)

Human     1 MPEIRVTPLGACPVLSWNLVLPPGRGSRAPSSTDTRTGFHVLPHGPLGCGPVILMCGAGFGHFEW 65
            |||||||||
Mouse     1 MPEIRVTPL-------------------------------------------------------- 9

Human    66 LAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFH 130
                |||||||||||||||:|||||||||||||:||||||||||||||:||||||||||||||||
Mouse    10 ----GAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDFLDCVIISHFH 70

Human   131 LDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVA 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    71 LDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVA 135

Human   196 VHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLL 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   136 VHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLL 200

Human   261 ITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPI 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   201 ITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPI 265

Human   326 YFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHA 390
            ||||||||||||||||||.||||||||||||||||||||||||||.|||||||||||||||||||
Mouse   266 YFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRTFADNPGPMVVFATPGMLHA 330

Human   391 GQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADA 455
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   331 GQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQMLEVKMQVEYMSFSAHADA 395

Human   456 KGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGL 520
            ||||||||||||||||||||||||||||:||||||.||:||||||||||||||||||||||||||
Mouse   396 KGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFRVSCYMPANGETVTLPTSPSIPVGISLGL 460

Human   521 LKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQE 585
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
Mouse   461 LKREMVQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLQDTRKEQE 525

Human   586 TALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSL 650
            |||||||||||.||||||||||||||||||:|:||||.|||||||||||||||||||||||||:|
Mouse   526 TALRVYSHLKSTLKDHCVQHLPDGSVTVESILIQAAAHSEDPGTKVLLVSWTYQDEELGSFLTTL 590

Human   651 LKKGLPQAPS 660
            ||.|||||||
Mouse   591 LKNGLPQAPS 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	426/436 (98%)
		INTS11-like_MBL-fold	70..264	CDD:293849	190/193 (98%)
Ints11	NP_082296.1	COG1782	4..446	CDD:441388	432/501 (86%)
		INTS11-like_MBL-fold	6..204	CDD:293849	194/257 (75%)
		HXHXDH motif	68..73		4/4 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q5TA45	469..479		9/9 (100%)