Protein Alignment INTS11 and ints11

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_001018457.1
• Gene: ints11 / 553648
• ZFINID: ZDB-GENE-050522-13
• Length: 598
• Species: Danio rerio
• Alignment Length: 657
• Identity: 503/657 - (76%)
• Similarity: 555/657 - (84%)
• Gaps: 61/657 - (9%)

Human     1 MPEIRVTPLGACPVLSWNLVLPPGRGSRAPSSTDTRTGFHVLPHGPLGCGPVILMCGAGFGHFEW 65
            ||:|:||||
Zfish     1 MPDIKVTPL-------------------------------------------------------- 9

Human    66 LAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFH 130
                |||||||||||||||.|||:|||||||||||||||||||||||||||||:|||||||||||
Zfish    10 ----GAGQDVGRSCILVSIGGKNIMLDCGMHMGFNDDRRFPDFSYITQNGRLTEFLDCVIISHFH 70

Human   131 LDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVA 195
            |||||||||.||||||||||||||||:|||||||||:|||.||||||.||||||||||||||||.
Zfish    71 LDHCGALPYMSEMVGYDGPIYMTHPTKAICPILLEDFRKITVDKKGETNFFTSQMIKDCMKKVVP 135

Human   196 VHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLL 260
            ::||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||::|
Zfish   136 LNLHQTVQVDDELEIKAYYAGHVLGAAMVQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPDIL 200

Human   261 ITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPI 325
            |:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
Zfish   201 ISESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKAPI 265

Human   326 YFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHA 390
            ||||||||||||||||||.||||||||||||||||||||||||||::||||||||||||||||||
Zfish   266 YFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRSYADNPGPMVVFATPGMLHA 330

Human   391 GQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADA 455
            |||||||:||||||||||||||||||||||||||:||:|||||||..|:||:|||||||||||||
Zfish   331 GQSLQIFKKWAGNEKNMVIMPGYCVQGTVGHKILNGQKKLEMEGRATLDVKLQVEYMSFSAHADA 395

Human   456 KGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGL 520
            ||||||:..|||.::||||||||||||||.|||||..::|:|||||||.|:.|:||:||.|||.|
Zfish   396 KGIMQLIRMAEPRNMLLVHGEAKKMEFLKDKIEQEFSISCFMPANGETTTIVTNPSVPVDISLNL 460

Human   521 LKREMA-QGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQ 584
            |||||| .|.||:||:||.:||||||||::.||||.|||||||||.||||||||||.|||...:.
Zfish   461 LKREMALGGPLPDAKRPRTMHGTLIMKDNSLRLVSPEQALKELGLNEHQLRFTCRVQLHDPHSDT 525

Human   585 ETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTS 649
            :|..|:|:|||||||.:.:||:|||:|.|||::::..:.:|:|..||:|:||:||||||||||::
Zfish   526 DTLSRIYTHLKSVLKSYSIQHVPDGTVIVESIVIKVTSSAEEPNLKVILLSWSYQDEELGSFLST 590

Human   650 LLKKGLP 656
            |||||||
Zfish   591 LLKKGLP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	396/436 (91%)
		INTS11-like_MBL-fold	70..264	CDD:293849	178/193 (92%)
ints11	NP_001018457.1	YSH1	5..416	CDD:440849	377/470 (80%)
		INTS11-like_MBL-fold	6..204	CDD:293849	182/257 (71%)
		HXHXDH motif	68..73		4/4 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q5TA45	470..480		6/9 (67%)