Protein Alignment INTS11 and Cpsf100

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 135/622 - (21%)
• Similarity: 237/622 - (38%)
• Gaps: 182/622 - (29%)

Human    74 DVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALP 138
            |....|.::.|....::||||.      |.:| |.::|.:..|....||.|::||....|.||||
  Fly    15 DESPPCYILQIDDVRILLDCGW------DEKF-DANFIKELKRQVHTLDAVLLSHPDAYHLGALP 72

Human   139 YFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQ 203
            |....:|.:.|||.|.|...:..:.:.|. .::....|:.:.|:...:....:|:..:..:|||.
  Fly    73 YLVGKLGLNCPIYATIPVFKMGQMFMYDL-YMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVS 136

Human   204 VDDE---LEIKAYYAGHVLGAAMFQI-KVGSESVVYTGDYNMTPDRHLGAAWIDKC-RPNLLITE 263
            :.|:   :.|....|||::|..:::| |||.|.:||..|:|...:|||....:|:. ||:||||:
  Fly   137 LKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITD 201

Human   264 STYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFS 328
            :..|...:..:|.|:...:..:.:||...|.|||.|...||..||..:|:..|:.....:..| |
  Fly   202 AYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAY-S 265

Human   329 TGLTEKANH----YYKLFIPWTNQKIRKTF--VQRNMFEFKHIKAFDRAFAD----NPGPMVVFA 383
            ..|....::    :.|..|.|.:.|:.|.|  .:.|.|:||||: ...:.||    ..||.||.|
  Fly   266 LALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQ-LCHSLADVYKLPAGPKVVLA 329

Human   384 TPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKI-----------LSGQRKLEMEG--- 434
            :...|.:|.:..:|.:||.|..|.:|:......||:..::           |..:|::::||
  Fly   330 STPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAEL 394

Human   435 ----------------------------------------------------------------- 434
                                                                             
  Fly   395 EEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVM 459

Human   435 ----------------------------------------------------------------- 434
                                                                             
  Fly   460 FPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDV 524

Human   435 ------------RQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKI 487
                        |:.:||..||:.:.|...:|.:.:::::.|..|..|:::||.|:..:.:.:..
  Fly   525 QLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHC 589

Human   488 EQELRVNCYMPANGETVTLPTSPSI-PVGISLGLLKR 523
            ||.:....:.|..||.:.:.:...| .|.::.||:.:
  Fly   590 EQNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQ 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	131/602 (22%)
		INTS11-like_MBL-fold	70..264	CDD:293849	61/194 (31%)
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	61/196 (31%)
		Beta-Casp	243..369	CDD:214983	36/127 (28%)
		RMMBL	539..600	CDD:462191	14/60 (23%)
		CPSF100_C	617..753	CDD:463836	3/10 (30%)