Protein Alignment INTS11 and Cpsf73

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 215/629 - (34%)
• Similarity: 318/629 - (50%)
• Gaps: 105/629 - (16%)

Human    70 GAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHC 134
            ||||:||||||::...||.:|||||:|.|.:.....|....|.     .|.:|.:.|||||||||
  Fly    24 GAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIE-----ADEIDLLFISHFHLDHC 83

Human   135 GALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQM------IKDCMKKV 193
            ||||:|.....:.|..:|||.|:||...:|.||.||       :|..|.||      ::..|:|:
  Fly    84 GALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKI-------SNISTEQMLYTEADLEASMEKI 141

Human   194 VAVHLHQTVQVDDELEIK--AYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCR 256
            ..::.|:.   .|.:.::  ||.||||||||||.|::....::||||::...||||.||.:...:
  Fly   142 ETINFHEE---RDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPMK 203

Human   257 PNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFW-ERMN 320
            |::|||||||.|.|.:.:..||..|...|.:.|::||:.|||||||||||||.::|:.|| :..:
  Fly   204 PDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPD 268

Human   321 L-KVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHI---KAFDRAFADNPGPMVV 381
            | ::|||:::.|.:|....|:.:|...|.:||:.....|.|.|:||   |..|. |.| .||.|:
  Fly   269 LHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGIDH-FED-IGPCVI 331

Human   382 FATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEY 446
            .|:|||:.:|.|.::|..|..:.||.||:.||||:||:...:||...::.....|.|.:.|.|:|
  Fly   332 MASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQKLPLNMSVDY 396

Human   447 MSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELR------VNCYMPANGETVT 505
            :|||||.|.:...:.:...:|..|:|||||..:|..||..:::|..      :..|.|.|...|.
  Fly   397 ISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNTHAVD 461

Human   506 L-------------PTSPSIPVGISLG--LLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSS 555
            |             ..:.:..||..|.  |:||:....||..:...:       ..|.:..:|:.
  Fly   462 LYFRGEKTAKVMGSLAAKNSEVGSKLSGVLVKRDFKYHLLAPSDLGK-------YTDMSMSVVTQ 519

Human   556 EQ------ALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVE 614
            .|      :|..|.|...::...|...|     |.|..|||:.         |::      :|||
  Fly   520 RQSIPWGSSLSTLELLLDRIGAGCVEVL-----EAERKLRVFG---------CIE------LTVE 564

Human   615 SVLLQAAAPSEDPGTKVLLVSW-------TYQDEELGSFLTSLL 651
            .              |::::.|       .|.|..|...:.|.|
  Fly   565 Q--------------KIIVMEWQATHVNDVYADAVLACIMQSEL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	182/454 (40%)
		INTS11-like_MBL-fold	70..264	CDD:293849	84/201 (42%)
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	84/201 (42%)
		YSH1	19..427	CDD:440849	173/419 (41%)
		CPSF73-100_C	486..680	CDD:463330	30/150 (20%)