Protein Alignment INTS11 and Snm1

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_649548.1
• Gene: Snm1 / 40669
• FlyBaseID: FBgn0037338
• Length: 763
• Species: Drosophila melanogaster
• Alignment Length: 699
• Identity: 119/699 - (17%)
• Similarity: 214/699 - (30%)
• Gaps: 295/699 - (42%)

Human     1 MPEIRVTPLGACPVLSWNLV-LPPGRGSRAPSSTDTRTGFHVLP-----HGPLG----------- 48
            |||.:::.      .|.:|| :.||     |:.:.|...:...|     ..|||
  Fly   205 MPEAKLSN------SSLDLVEISPG-----PNKSPTNNFYRSSPAAITKESPLGKNSKKGTVRKQ 258

Human    49 -----CGPVILMCGAGFGHFEWLAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDF 108
                 |.|..::.|..|                  |:                    |..:|.:.
  Fly   259 RKPKPCPPYKVVEGTSF------------------CV--------------------DGFQFGEI 285

Human   109 SYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVD 173
            ..:|.          ..::|||.||     |......:..|:|       :.||
  Fly   286 EGVTH----------YFLTHFHADH-----YIGLTKKFCHPLY-------VSPI----------- 317

Human   174 KKGEANFFTSQMIKDCMKKVVAVHLH-----QTVQVDDELEIKAYYAGHVLGAAMFQIKVGS-ES 232
                    ::::::..: |:...|:|     ||:.||. :::.|..|.|..||.||..|:.| |.
  Fly   318 --------SARLVRTFI-KLDETHIHEIDVDQTLDVDG-VQVTALEANHCPGALMFFFKLSSGEC 372

Human   233 VVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLI 297
            :::|||:..:.|......:.:....:||..::||..        :..||..: .|:|:|...::.
  Fly   373 ILHTGDFRASADMESLPIFWNHSNIDLLYLDTTYMN--------KNYDFCHQ-SESVDRAVDLVR 428

Human   298 PVFALGRAQELCILL-------ETFW----ERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIR 351
            .......|:.:.|:.       |..|    :...::|                     ||... |
  Fly   429 AFLEKNAAKRILIVCGSYVIGKEKIWLALAKEFTMRV---------------------WTESN-R 471

Human   352 KTFVQ-RNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKW------------AGN 403
            .|.|: .|..:...:...||:.|:    :.|.|. |.:.....:..|.::            :|.
  Fly   472 STAVRCLNWPDLDSVLTEDRSGAN----LHVIAM-GKISYPSLVDYFTEFEDQYDMLLGIRPSGW 531

Human   404 EKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPE 468
            |||.  .|.|                    |:::..:.::     :|.|:..|.:.:.|...:|:
  Fly   532 EKNS--KPSY--------------------GKRISTIGIE-----YSEHSSYKELERFVRFLKPK 569

Human   469 SV---------LLVHGE----------------------------AKKMEFLKQKIEQELRVN-- 494
            .|         |.|.||                            ..|..|.|...:.|:.::
  Fly   570 RVISTVPVGRDLYVTGEVPIRWYKYEGRASMLRTGFQPSISTFLATPKRAFAKFSADTEMFLSPV 634

Human   495 ----------------------------------CY-----MPANGETVTLPTSPSIPVGISLGL 520
                                              |:     :|...|.:...|||:..:...|..
  Fly   635 DENASKGSEDKKDDDRESVVPTNHVTIISDTPEECFQTDSKIPVKNEPLAPDTSPNSEIVAQLNA 699

Human   521 LKREMA--------QGLLPEAKK-PRL-LHGTLIMKDSNFRLVSSEQAL 559
            ::.|:.        :.:.|:|.. ||: ...|....|.|...|...||:
  Fly   700 MESEIPYVEIDIKNETIAPDAVLIPRVPTEDTFQSTDCNVIGVQKSQAV 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	86/544 (16%)
		INTS11-like_MBL-fold	70..264	CDD:293849	37/199 (19%)
Snm1	NP_649548.1	SNM1A-1C-like_MBL-fold	252..408	CDD:293831	43/236 (18%)
		DRMBL	481..578	CDD:429512	20/128 (16%)