Protein Alignment INTS11 and IntS9

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_648838.3
• Gene: IntS9 / 39763
• FlyBaseID: FBgn0036570
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 688
• Identity: 142/688 - (20%)
• Similarity: 245/688 - (35%)
• Gaps: 204/688 - (29%)

Human    74 DVGRSCILVSIAGKNVMLDCG---------MHMGFNDDRRF---PDF------------------ 108
            |:.:.|.:::..|..:|||||         :.:.|....::   |:|
  Fly     9 DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCC 73

Human   109 ---------SYITQNGRLTDF--LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPI 162
                     .:.....::.||  :|.::||::.  :..||||.:|..|:.|.:|.|.||..|...
  Fly    74 GRVFVDSTPEFNLPMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIGRF 136

Human   163 LLE---DYRKI-----------------------AVDKKGEANFFTSQMIKDCMKKVVAVHLHQT 201
            .||   ||.::                       |...|.....|:.:.::..:.||.      .
  Fly   137 FLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVT------I 195

Human   202 VQVDDELEIKAYY------AGHVLGAAMFQIKVGSESVVY-TGDYNMTP-DRHLGAAWIDKCRPN 258
            :..|::|:|...:      :|:.||::.:.:....|.:.| :|...:|. .|.:..:.: |....
  Fly   196 MGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSAL-KHADV 259

Human   259 LLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNL-K 322
            |::|..|.|.|:....:..|  ....|..|:...|..|||.:..|...:|...|....|...| .
  Fly   260 LIMTGLTQAPTVNPDTKLGE--LCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLENAGLNN 322

Human   323 VPIYFSTGLTEKANHYYKLFIPW-TNQKIRKTFVQRNMF---------EFKHIK-AFDRAFA-DN 375
            ||::|.:.:.:.:..|..:...| ::.|..|.::..:.|         :.||.. .|...|: |.
  Fly   323 VPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSEGFSKDF 387

Human   376 PGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVL-- 438
            ..|.|||.....|..|.::.....|..|..|.:|.                 .:.:....|||
  Fly   388 RQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIF-----------------TEPDFPYLQVLAP 435

Human   439 --EVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLV-------HGEAKKMEFLKQKIEQELRVN 494
              .:.|:..|.......:.:...:|:.:.:| :||::       |..|..: |::|..::.:...
  Fly   436 FQPLAMKAFYCPIDTSLNYQQANKLIKELKP-NVLVIPEAYTKPHPSAPNL-FIEQPDKKIITFK 498

Human   495 CYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQAL 559
            |     ||.:.||             |||          |..|:             .::||.|.
  Fly   499 C-----GEIIRLP-------------LKR----------KLDRI-------------YITSELAQ 522

Human   560 KELGLAEHQLRFTCRVHLHDTRKEQETALRV-YSHLKSVL----KDHCVQHLPDGSVTVESVLLQ 619
            |                    ...:|.|..| :|.|..||    |.||:|...| ||..|::...
  Fly   523 K--------------------ISPKEVAAGVTFSTLTGVLQVKDKVHCIQPCAD-SVKDETISSN 566

Human   620 AAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQ 657
            :|...||     :|.:..|   |.||.....:.|.|.|
  Fly   567 SAPTKED-----VLKNVKY---EYGSIDVDAVMKKLAQ 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	105/530 (20%)
		INTS11-like_MBL-fold	70..264	CDD:293849	51/264 (19%)
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:451500	50/263 (19%)
		Beta-Casp	304..428	CDD:214983	27/140 (19%)