Protein Alignment INTS11 and ysh1

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_594263.2
• Gene: ysh1 / 2542258
• PomBaseID: SPAC17G6.16C
• Length: 757
• Species: Schizosaccharomyces pombe
• Alignment Length: 508
• Identity: 174/508 - (34%)
• Similarity: 281/508 - (55%)
• Gaps: 49/508 - (9%)

Human    70 GAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF----LDCVIISHFH 130
            |||.:|||||.::...||.||||.|:|..:......|.|.         :|    :|.::|||||
pombe    25 GAGNEVGRSCHVIQYKGKTVMLDAGVHPAYTGLSALPFFD---------EFDLSTVDVLLISHFH 80

Human   131 LDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVA 195
            |||..:|||..:...:.|.::|||||:|:|..||.||.|:: :...|...:..:.:.....::.|
pombe    81 LDHVASLPYVMQKTNFRGRVFMTHPTKAVCKWLLSDYVKVS-NVGMEDQLYDEKDLLAAFDRIEA 144

Human   196 VHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLL 260
            |..|.|::|:. ::...|:|||||||.|:.:::...::::||||:...||||..|.:...||::|
pombe   145 VDYHSTIEVEG-IKFTPYHAGHVLGACMYFVEMAGVNILFTGDYSREEDRHLHVAEVPPKRPDVL 208

Human   261 ITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFW-ERMNLK-V 323
            ||||||.|.....:..:|...|..:|.|:..||:||:|||||||||||.::|:.:| ..::|: |
pombe   209 ITESTYGTASHQPRLEKEARLLNIIHSTIRNGGRVLMPVFALGRAQELLLILDEYWNNHLDLRSV 273

Human   324 PIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAF-DRAFADNPGPMVVFATPGM 387
            |||:::.|..|....::.::...|..|||.|.:||.|.|:.:|:. :....|:.||.|:.|:|||
pombe   274 PIYYASSLARKCMAIFQTYVNMMNDNIRKIFAERNPFIFRFVKSLRNLEKFDDIGPSVILASPGM 338

Human   388 LHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKI---------LSGQRKLEMEGRQVLEVKMQ 443
            |..|.|..:..:||.:.:|.:::.||.|:||:..:|         ||||:         :..:|.
pombe   339 LQNGVSRTLLERWAPDPRNTLLLTGYSVEGTMAKQITNEPIEIVSLSGQK---------IPRRMA 394

Human   444 VEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKI-----EQELRVNCYMPANGET 503
            ||.:||:||.|.....:.:.....:.::|||||...|..||..:     .:::.|..|.|.|...
pombe   395 VEELSFAAHVDYLQNSEFIDLVNADHIILVHGEQTNMGRLKSALASKFHNRKVDVKVYTPRNCVP 459

Human   504 VTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSE 556
            :.||....        .|.|.:.:..:.:.|:..::.|.||.||:|::|:|:|
pombe   460 LYLPFKGE--------RLVRALGKVAVHKPKEGDIMSGILIQKDANYKLMSAE 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	160/456 (35%)
		INTS11-like_MBL-fold	70..264	CDD:293849	73/197 (37%)
ysh1	NP_594263.2	YSH1	19..428	CDD:440849	152/422 (36%)
		CPSF3-like_MBL-fold	19..212	CDD:293850	73/197 (37%)
		CPSF73-100_C	485..693	CDD:463330	9/20 (45%)