Protein Alignment INTS11 and ints-11

DIOPT Version :10

• Sequence 1: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_495706.2
• Gene: ints-11 / 174310
• WormBaseID: WBGene00008642
• Length: 608
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 335/562 - (59%)
• Similarity: 423/562 - (75%)
• Gaps: 33/562 - (5%)

Human    70 GAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHC 134
            ||||||||||||::|.|||:|:|||||||:.|||||||||||...|||||:||||||||||||||
 Worm    14 GAGQDVGRSCILITIGGKNIMVDCGMHMGYQDDRRFPDFSYIGGGGRLTDYLDCVIISHFHLDHC 78

Human   135 GALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLH 199
            |:||:.||:||||||||||:||:||||:|||||||:..|.|||.|||||..||:||||||...||
 Worm    79 GSLPHMSEIVGYDGPIYMTYPTKAICPVLLEDYRKVQCDIKGETNFFTSDDIKNCMKKVVGCALH 143

Human   200 QTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWI-DKCRPNLLITE 263
            :.:.||:||.|:|:|||||||||||:|::|..||:||||||||||||||||.: ...||.:||:|
 Worm   144 EIIHVDNELSIRAFYAGHVLGAAMFEIRLGDHSVLYTGDYNMTPDRHLGAARVLPGVRPTVLISE 208

Human   264 STYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFS 328
            ||||||||||||.||||||:||||.|.:||||:|||||||||||||||||::||||.|.||||||
 Worm   209 STYATTIRDSKRARERDFLRKVHECVMKGGKVIIPVFALGRAQELCILLESYWERMALNVPIYFS 273

Human   329 TGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQS 393
            .||.|:||.||:|||.|||:.|:||||:||||||||||..::...|.|||.|:|:||||||.|||
 Worm   274 QGLAERANQYYRLFISWTNENIKKTFVERNMFEFKHIKPMEKGCEDQPGPQVLFSTPGMLHGGQS 338

Human   394 LQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGI 458
            |::|:||..:..||:|||||||.||||.::::|::|:|:: :::.|:::.|||||||||||||||
 Worm   339 LKVFKKWCSDPLNMIIMPGYCVAGTVGARVINGEKKIEID-QKMHEIRLGVEYMSFSAHADAKGI 402

Human   459 MQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKR 523
            |||:.|.||:.|:.|||||.||||||.|:|:|.:|..:||||||||.:...|.:.:.:.|..:.|
 Worm   403 MQLIRQCEPQHVMFVHGEASKMEFLKGKVEKEYKVPVHMPANGETVVISAQPKLDIRVPLEKIDR 467

Human   524 EMAQGLLPEAKKPRLLHGTLIMKDSNFRL-----VSSEQALKE-------LGLAE----HQLRFT 572
            .::....| ||........|:....|.||     ..||..:|:       |.|:|    .::.:
 Worm   468 SLSLDPNP-AKSECPFVAELVYDQENERLNIMSTAESEDLIKDKNCMPITLSLSEIIKGKKVNW- 530

Human   573 CRVHLHDTRKEQETALRVYS-HLKSVLKDHCVQHLPDGSVTV 613
                     ||....|.:|. ||:  |||..:: :.||.:|:
 Worm   531 ---------KELSNELLLYDPHLQ--LKDDGIE-MFDGEITI 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	307/436 (70%)
		INTS11-like_MBL-fold	70..264	CDD:293849	142/194 (73%)
ints-11	NP_495706.2	YSH1	9..422	CDD:440849	288/408 (71%)
		INTS11-like_MBL-fold	10..209	CDD:293849	142/194 (73%)