DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctnnb1 and p120ctn

DIOPT Version :9

Sequence 1:	NP_001016958.1	Gene:	ctnnb1 / 549712	XenbaseID:	XB-GENE-487200	Length:	781	Species:	Xenopus tropicalis
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	874	Identity:	179/874 - (20%)
Similarity:	303/874 - (34%)	Gaps:	265/874 - (30%)

- Green bases have known domain annotations that are detailed below.

Frog     8 MELDMAMEP-------------DRKAAVSHWQQQSYLDSGIHSGA-TTTAPSLSGKGNPEDEDVD 58
            |:|.:..||             |:.:|..:.....|:......|| |..||..|      ...::
  Fly    22 MDLSLTHEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCS------QNKIE 80

Frog    59 TNQVLYEWEQGFSQSFTQDQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQ 123
            ||.             |.:.:.||:.....|..:.|:|..:.:|.:.|:...:...||.:....
  Fly    81 TNS-------------TDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEA- 131

Frog   124 RLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKA-AVMVHQLSKKEASRHA 187
                   ::.:...:..||.......:...|...:..||.    :|.| ||...|....::|  |
  Fly   132 -------VVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDN----INGAEAVADSQCRTFKSS--A 183

Frog   188 IMRSPQMVSAIVRTMQ------------NTNDV-ETARCTAGTLHNLSHHREGLLAIFKSGGIPA 239
            ..:.||...:.:.|:.            :.||: .|.|                   ::...:..
  Fly   184 EFKLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTMR-------------------WRDPNLSE 229

Frog   240 LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQIL 304
            ::..|.:|..::...|...|.:|....:..|...|..||:..:|.||:..:.:........|:.|
  Fly   230 VISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNL 294

Frog   305 AYG--NQESKLIILASGGPQALVNIM-RTYSYE------KLLWTTSRV--LK--------VLSVC 350
            :||  |.|:|..|..:||..|||::: |:...|      .:||..|..  ||        |..||
  Fly   295 SYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVC 359

Frog   351 SSNKPAIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDIN 415
            |..||    ..|..|:....|..| .:.:|....|||:|.|.   |...|.|.....|
  Fly   360 SVIKP----HSGWDAVCCGETCFS-TVFRNASGVLRNVSSAG---EHARGCLRNCEHL------- 409

Frog   416 VVTCAAGIL-SNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQE-- 477
             |.|...:: :::..||..||.:                        |..:|.||:|:.|.||
  Fly   410 -VECLLYVVRTSIEKNNIGNKTV------------------------ENCVCILRNLSYRCQEVD 449

Frog   478 -------------------------------------------------AEMAQNAV---RLHYG 490
                                                             |:.::::|   :|:.|
  Fly   450 DPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLNKG 514

Frog   491 L-----PVVVK----LLHPPSHWPLIKATVGLIRNLALC---PA--NHAPLREQGAIPRLVQLLV 541
            .     |.||:    ||...|:...::|..|.|:||:.|   |:  ..|.:|::..:|.||:||
  Fly   515 YEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILVELL- 578

Frog   542 RAHQDTQRRTSMGGTQQQFVEGVRME--EIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLY 604
                                   |||  .:|.....||..||.|..|:.:| |...:...||.|
  Fly   579 -----------------------RMEVDRVVCAVATALRNLAIDQRNKELI-GKYAMRDLVQKL- 618

Frog   605 SPIENIQR-----------VAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNE---GVATYA 655
             |..|:|.           |.|.:...:.::.|.:.::...|....|..:...:.:   .|..:|
  Fly   619 -PSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFA 682

Frog   656 AAVLFRMSED-------KPQDYKKRLSVELTSSLFRTEP-MPWNEAADLGLDIGAQGEPLGYRQD 712
            :.||:.|.:.       |...:|::..|....:...|.| .|.|....|...:.:||..   |.:
  Fly   683 SQVLYTMWQHNELRDVYKKNGWKEQDFVSKHFTAHNTPPSSPNNVNNTLNRPMASQGRT---RYE 744

Frog   713 DPSYRSFHAPGY-GQDAMGMDSMMDHDMA 740
            |.:.:...:..| ..|:.|  ::|.::.|
  Fly   745 DRTIQRGTSTLYSANDSSG--AVMSNESA 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctnnb1	NP_001016958.1	armadillo repeat	153..178	CDD:293788	7/25 (28%)
		armadillo repeat	188..221	CDD:293788	7/45 (16%)
		PLN03200	216..>661	CDD:215629	117/548 (21%)
		armadillo repeat	230..262	CDD:293788	4/31 (13%)
		ARM	230..262	CDD:214547	4/31 (13%)
		armadillo repeat	270..306	CDD:293788	9/35 (26%)
		armadillo repeat	312..347	CDD:293788	14/51 (27%)
		ARM	350..390	CDD:214547	12/39 (31%)
		armadillo repeat	354..389	CDD:293788	10/34 (29%)
		armadillo repeat	402..427	CDD:293788	4/25 (16%)
		armadillo repeat	435..473	CDD:293788	6/37 (16%)
		armadillo repeat	482..517	CDD:293788	12/46 (26%)
		armadillo repeat	524..582	CDD:293788	14/59 (24%)
		Arm	583..622	CDD:366143	12/49 (24%)
		armadillo repeat	587..621	CDD:293788	10/44 (23%)
		armadillo repeat	629..662	CDD:293788	6/35 (17%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	29/113 (26%)
		armadillo repeat	227..252	CDD:293788	4/24 (17%)
		armadillo repeat	260..296	CDD:293788	9/35 (26%)
		armadillo repeat	304..339	CDD:293788	11/34 (32%)
		ARM	307..442	CDD:237987	43/174 (25%)
		armadillo repeat	347..392	CDD:293788	13/49 (27%)
		armadillo repeat	515..556	CDD:293788	12/40 (30%)
		ARM	516..643	CDD:237987	40/153 (26%)
		armadillo repeat	562..596	CDD:293788	13/57 (23%)
		armadillo repeat	601..641	CDD:293788	11/42 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030