DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PPM1B and Pp2C1

DIOPT Version :9

Sequence 1:	XP_016859884.1	Gene:	PPM1B / 5495	HGNCID:	9276	Length:	487	Species:	Homo sapiens
Sequence 2:	NP_001284867.1	Gene:	Pp2C1 / 31404	FlyBaseID:	FBgn0022768	Length:	1427	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	142/576 - (24%)
Similarity:	220/576 - (38%)	Gaps:	165/576 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    19 GNGLRYGLSSMQGWRVEMEDAHTAVV---GIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHIT 80
            |..:|......||.|..|||..:...   .|.|.|| ::||.:||||.|...|.:...||:..|.
  Fly   253 GVNMRVTGQCCQGGRKYMEDQFSVAYQESPITHELE-YAFFGIYDGHGGPEAALFAKEHLMLEIV 316

Human    81 TNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYM----RNFSDLRNG-MDRSGSTAVGVMIS 140
            ..:.|.:.         ..|:|...||.|::.....|    ..:....|| :..:|:||....:.
  Fly   317 KQKQFWSD---------QDEDVLRAIREGYIATHFAMWREQEKWPRTANGHLSTAGTTATVAFMR 372

Human   141 PKHIYFINCGDSRAVL------YRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ----RVNGS 195
            .:.||..:.|||..||      .||.:....|.||||.:..||.|||.:||:|.|:    ||..:
  Fly   373 REKIYIGHVGDSGIVLGYQNKGERNWRARPLTTDHKPESLAEKTRIQRSGGNVAIKSGVPRVVWN 437

Human   196 ----------------------LAVSRALGD---YDYKCVDGKGPTEQLVSPEPEVYEILRAEED 235
                                  |||:|:|||   |:.:.      .|.:|||:|:| ::::....
  Fly   438 RPRDPMHRGPIRRRTLVDEIPFLAVARSLGDLWSYNSRF------KEFVVSPDPDV-KVVKINPS 495

Human   236 EF--IILACDGIWDVMSNEELCEYVKSRLEVSD-----DLENVCNWVVDTCL-----HKGSRDNM 288
            .|  :|...||:|:|::.:|..:.|:....:.:     |:.|....:||..|     .|...||.
  Fly   496 TFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGEILNEQDVMNPSKALVDQALKTWAAKKMRADNT 560

Human   289 SIVLVCFSNA--------PKVSDEAVKKDSELDKHLESRVEGTFFKKPTEIMEKSGEEGMPDLAH 345
            |:|.|..:.|        |..|..|:.:|::|:..|              ::|:..||
  Fly   561 SVVTVILTPAARNNSPTTPTRSPSAMARDNDLEVEL--------------LLEEDDEE------- 604

Human   346 VMRILSAENIPNLP-------------PGGGLAGKRNVIEAVYS---------RLNPHRESDGAS 388
             :..|..||  |.|             |...||.:.:..||..:         .|:...|:....
  Fly   605 -LPTLDVEN--NYPDFLIEEHEYVLDQPYSALAKRHSPPEAFRNFDYFDVDEDELDEDEETVEED 666

Human   389 DEAEESGSQGKLVEALRQMRINHRGNYRQ--------------------------LLEEMLTSYR 427
            :|.||...:.|.|..|:|...|.|..:|:                          |..:|.:...
  Fly   667 EEEEEEEEETKSVGILQQSLFNPRKTWRKSTINNSWSGVTEPEPEPDPEPDRIDVLTLDMYSHTS 731

Human   428 LAKVEG-----EESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSS--NE 476
            :.|...     .:|..:||.||.:      ..::..|.|.||....||..:|  ||
  Fly   732 IDKGTNYGGSIAQSSIDPAETAEN------RELSELEQHLESSYSFAESYNSLLNE 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPM1B	XP_016859884.1	None
Pp2C1	NP_001284867.1	PP2Cc	256..567	CDD:238083	92/327 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810