DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SOHLH2 and Sohlh2

DIOPT Version :9

Sequence 1:	NP_060296.2	Gene:	SOHLH2 / 54937	HGNCID:	26026	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_083213.2	Gene:	Sohlh2 / 74434	MGIID:	1921684	Length:	467	Species:	Mus musculus

Alignment Length:	420	Identity:	218/420 - (51%)
Similarity:	285/420 - (67%)	Gaps:	3/420 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASSIICQEHCQISGQAKIDILLVGDVTVGYLADTVQKLFANIAEVTITISDTKEAAALLDDCIF 65
            ||..|...|..:..||.::::|||||.|..:||.::||.|.:.|::|:|||:.|:.|.||....|
Mouse     1 MADRISTGELGRRPGQGRVNLLLVGDATRYFLAGSMQKFFPSTAQITLTISNVKKVAVLLAANSF 65

Human    66 NMVLLKVPSSLSAEELEAIKLIRFGKKKNTHSLFVFIIPENFKGCISGHGMDIALTEPLTMEKMS 130
            :::.|||.|:|:|||.||.||||.|||||||.||.|:|||..||.:|.:|.||:.:||||:||::
Mouse    66 DIIFLKVTSTLTAEEQEAAKLIRSGKKKNTHLLFAFVIPERLKGYVSEYGADISFSEPLTLEKVN 130

Human   131 NVVKYWTTCPSNTVKTENATGPEELGLPLQRSYSEHLGYFPTDLFACSESLRNGNGLELNASLSE 195
            .|:.||.|..:|| ..||...|.|..|..|.|.||..|.|.||:|.|||.|:|...|.|.|.||.
Mouse   131 TVIHYWKTYFTNT-DMENTELPPECRLYFQTSRSELGGRFSTDMFLCSELLKNDARLGLKAPLSS 194

Human   196 FEKNKKISLLHSSKEKLRRERIKYCCEQLRTLLPYVKGRKNDAASVLEATVDYVKYIREKISPAV 260
            .:|:|:.|.|||:||||||||||.||||||||||||||||:|.|||:||||||||.:||.:|||:
Mouse   195 LDKSKQASFLHSTKEKLRRERIKSCCEQLRTLLPYVKGRKSDVASVIEATVDYVKQVRESLSPAI 259

Human   261 MAQITEALQSNMRFCKKQQTPIELSLPGTVMAQRENSVM-STYSPERGLQFLTNTCWNGCSTPDA 324
            |||:|||:|:|.||.|:|. ||||.||.:..:|||:::: |.:||.:.:|.|.:...|..|...|
Mouse   260 MAQVTEAIQNNRRFSKRQM-PIELFLPFSATSQREDAMLTSAFSPVQEIQLLADRGLNVYSMTAA 323

Human   325 ESSLDEAVRVPSSSASENAIGDPYKTHISSAALSLNSLHTVRYYSKVTPSYDATAVTNQNISIHL 389
            ..:|:.|||....|.||::|.|.|||.:.|.|.||||.|:|:|.|.....::|.|.||||||.:|
Mouse   324 GGALEGAVRGQPGSVSESSIEDLYKTRVPSTARSLNSFHSVKYTSGTVSPHEAAARTNQNISTYL 388

Human   390 PSAMPPVSKLLPRHCTSGLGQTCTTHPNCL 419
            |...|.||..:|:||.:.|.....|.||||
Mouse   389 PPTAPSVSNFIPQHCNAMLCPARPTSPNCL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOHLH2	NP_060296.2	HLH	197..257	CDD:238036	46/59 (78%)
Sohlh2	NP_083213.2	HLH	205..256	CDD:238036	42/50 (84%)
Sohlh2	NP_083213.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955331
Domainoid	1	1.000	179	1.000	Domainoid score	I28565
eggNOG	1	0.900	-	-		E1_2DZHG
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I13741
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG34866
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0015416
OrthoInspector	1	1.000	-	-		oto127738
orthoMCL	1	0.900	-	-		OOG6_128096
Panther	1	1.100	-	-	LDO	PTHR16223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13464
SonicParanoid	1	1.000	-	-		X12265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.330