DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOHLH2 and srebf2

DIOPT Version :9

Sequence 1:	NP_060296.2	Gene:	SOHLH2 / 54937	HGNCID:	26026	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_001082935.1	Gene:	srebf2 / 100037309	ZFINID:	ZDB-GENE-070410-8	Length:	1099	Species:	Danio rerio

Alignment Length:	375	Identity:	78/375 - (20%)
Similarity:	122/375 - (32%)	Gaps:	112/375 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   112 SGHGMDIALTEPLTMEKMSNVVK--------------YWTTCPSNT---VKTENATGPEELGLPL 159
            :|..:....|.|.|:..||..|.              ..||.|..|   ...::.||...|..|:
Zfish   191 AGQTIQTLSTAPTTVHTMSQQVPVLVHQPQILKTDSLLLTTKPDGTQVLSTVQSPTGITTLTTPI 255

Human   160 QRSYSEHLGYFPTDLFACS-----------------ESLRNGNGLELNASLSEFEKNKKIS---- 203
            |.:..:    .|| |.:.:                 :.|.:|....:..:....|::..:.
Zfish   256 QTTALQ----MPT-LMSSNILTTVPVVMGGGDKLPIKQLSSGPAHNIGGARVGVEQSPVVGPGGV 315

Human   204 -------LLHSSKEKLRRERIKYCCEQLRTLLPYVKGRKNDA----ASVLEATVDYVKYIREKIS 257
                   ..|:..||..|..|.....:||.|   |.|  |||    :.||...:||:||:::...
Zfish   316 VKEGERRTTHNIIEKRYRSSINDKILELRDL---VLG--NDAKMHKSGVLRKAIDYIKYLQQVNH 375

Human   258 PAVMAQIT--EALQSNMRFCKKQ---QTPIELSLPGTVMAQRENSVMSTYSPERGLQFLTNTCWN 317
            ......:|  .|.|.|...|...   :...|:||.....:...:|..:..||.
Zfish   376 KLRQENLTLKMANQKNKSACVSDVDLELKAEVSLISPPPSDSGSSSPAQLSPY------------ 428

Human   318 GCSTPDAESSLDEAVRVPSSSASENAIGDPYKTH-----ISSAALSLNSLHTVRYYSKVTPSYDA 377
             |...:..|.|.|..::.|...|.:.:|...::.     :|...||||.|          ||.
Zfish   429 -CIDSEPGSPLLEHEQLKSEPDSPSCVGVMDRSRLLLCALSFLCLSLNPL----------PSL-- 480

Human   378 TAVTNQNISIHLPSAMPPVSKLLPRHCTSGLGQTCT--THPNCLQQFWAY 425
                   :....|:..|.|         :|.|.|.|  :.|...|.|.|:
Zfish   481 -------LGAEAPAGSPEV---------AGHGPTRTLFSLPAQTQSFGAW 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOHLH2	NP_060296.2	HLH	197..257	CDD:238036	20/74 (27%)
srebf2	NP_001082935.1	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..47
		TFIIA	57..>221	CDD:281188	7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..107
		HLH	321..371	CDD:278439	19/54 (35%)
		Leucine-zipper	370..391		3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910