DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZSCAN32 and zbtb20

DIOPT Version :9

Sequence 1:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens
Sequence 2:	XP_017946862.1	Gene:	zbtb20 / 100302397	XenbaseID:	XB-GENE-993556	Length:	751	Species:	Xenopus tropicalis

Alignment Length:	541	Identity:	131/541 - (24%)
Similarity:	197/541 - (36%)	Gaps:	131/541 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   181 APQAPRNLPQN-TGLHDQETGAVVWTAGSQGPAMRDNRAVSLCQQEWMCPGPAQRALYRGATQRK 244
            |.:.||..|:: |.....:|.:....:..|....|...|:..|.   |..|..:|:.|.||..
Frog   135 AQETPRGTPESGTSGQSSDTESNYLQSHRQHSVDRIYSALYTCS---MHNGSGERSFYSGALV-- 194

Human   245 DSHVSLATGVPWGY--EETKTLLAILSSSQFYGKLQTCQQNSQIYRAMAEGLWEQGFLRTPE--Q 305
             ||...|.|:|..:  ||...:..|...||                     ..|:....|||  .
Frog   195 -SHHKTALGLPRQHHMEEPSWITRIHQRSQ---------------------RMERYLSATPETTH 237

Human   306 CR-----TKFKSL------------------QLSYRKVRRGRVPEPCIFYEEMNALSGSWASAPP 347
            ||     .:.::|                  |.|.:.:.|.. .|.|.  |:.:...|:.:....
Frog   238 CRKQPRPVRIQTLMGNIHIKQEVEDDYDYYGQQSSQALERNE-SEECT--EDTDQAEGTESEPKG 299

Human   348 MASDA-VPGQEGSDIEAGELNHQNGEPTEVEDGTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRL 411
            .:.|: |....|::.::||   |...|....:|..:.:..:..:....|.|  ..|.|.|
Frog   300 ESFDSGVSSSIGTEPDSGE---QQYMPILSREGPQEPSQAESNNLPTEGSE--NQDQPHL----- 354

Human   412 GFEFKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEP----------------- 459
              |..:...:.||..|.:    :.:......:||...|..|...::.|
Frog   355 --ETSSSSPERNLDTDST----VLRVSNSTDKGVVQTSVTQSIAQTMPNTQLYLRQTETLTSNLR 413

Human   460 -----TSRRQCRNSPGES----------------------EEKTPSQEKMSHQSFCARDKACTHI 497
                 ||..|...:.|.:                      .:..|.|:    ..|....::....
Frog   414 MPLTLTSNTQVIGTAGNTYLPTLFTTQAAGSGPKPFLFSLPQSIPGQQ----TQFVTVPQSGISP 474

Human   498 LCG--KNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSE 560
            ..|  :|.||:.||. ..|...:|..:|..|.|||:.....|:|..:|||||||:||.|.:.||.
Frog   475 FAGQYQNTSQTSHST-SSAQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSL 538

Human   561 RSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHRR 625
            :..|..|:.||||.|.|||..|.|.|.|.|||.||.|.|.|||.|:|.:|.|:|::.:....|..
Frog   539 KDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVA 603

Human   626 IH-----TGESPYKCAVCGKI 641
            :|     |...|...|..|.:
Frog   604 LHSATNGTASLPITAAPPGSV 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379	10/31 (32%)
		Myb_DNA-bind_4	253..334	CDD:290549	19/107 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395		8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		8/74 (11%)
		COG5048	<455..668	CDD:227381	70/238 (29%)
		zf-C2H2	522..543	CDD:278523	7/20 (35%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		zf-H2C2_2	535..559	CDD:290200	12/23 (52%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		zf-H2C2_2	563..588	CDD:290200	13/24 (54%)
		C2H2 Zn finger	579..599	CDD:275368	11/19 (58%)
		zf-H2C2_2	591..616	CDD:290200	14/24 (58%)
		C2H2 Zn finger	607..627	CDD:275368	5/19 (26%)
		zf-H2C2_2	623..644	CDD:290200	6/24 (25%)
		C2H2 Zn finger	635..655	CDD:275368	2/7 (29%)
		zf-H2C2_2	647..671	CDD:290200
		zf-C2H2	661..683	CDD:278523
		C2H2 Zn finger	663..683	CDD:275368
zbtb20	XP_017946862.1	BTB_POZ_ZBTB20_DPZF	6..122	CDD:349517
		SEEEED	272..369	CDD:373302	21/111 (19%)
		zf-C2H2	499..521	CDD:333835	7/21 (33%)
		C2H2 Zn finger	501..521	CDD:275368	7/19 (37%)
		zf-C2H2	527..549	CDD:333835	8/21 (38%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
		zf-H2C2_2	541..566	CDD:372612	13/24 (54%)
		zf-C2H2	555..577	CDD:333835	13/21 (62%)
		C2H2 Zn finger	557..577	CDD:275368	11/19 (58%)
		zf-H2C2_2	569..594	CDD:372612	14/24 (58%)
		C2H2 Zn finger	585..605	CDD:275368	5/19 (26%)
		PRK14959	<606..>691	CDD:184923	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910