DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RASIP1 and myo51

DIOPT Version :9

Sequence 1:	NP_060275.2	Gene:	RASIP1 / 54922	HGNCID:	24716	Length:	963	Species:	Homo sapiens
Sequence 2:	NP_596233.1	Gene:	myo51 / 2540560	PomBaseID:	SPBC2D10.14c	Length:	1471	Species:	Schizosaccharomyces pombe

Alignment Length:	322	Identity:	62/322 - (19%)
Similarity:	122/322 - (37%)	Gaps:	66/322 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   643 LRPLMLWMANTTELLSFVQEKVLEMEKEADQ---EDPQLCNDL---------ELCDEAMALLDEV 695
            |:.::.|.|...::.||:.. :|.:.....|   ||  |.|.|         .|.:...:|:.::
pombe  1174 LQAVLYWFATLHKIRSFLVH-LLSINSHGKQSVVED--LWNPLILKFSKHFSNLENSFHSLVQKL 1235

Human   696 IMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAMPPGLR--PTLGVFQAALELT 758
            :.|..:.|:..|..:  ..||..:|:             |:....|.|:.  ..:.......:|.
pombe  1236 LSCCTEGSINALLNS--KCLPEFIDA-------------ADENTTPTGMNIYELIDRMNLIHKLL 1285

Human   759 SQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGD 823
            ....|.|:|:..|..::..........:|:   .||..|.|..|.|:..|..|:::|....|:..
pombe  1286 ISSALQPNLLELTISHMLQHIGQRAFQTLI---HGRSPYTWKSASQVSYNASLLINWCHQKGISY 1347

Human   824 IATEFFRKLSMAVNLLCVPRTSL----LKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAA 884
            :.:... .|..:..:.|:.:...    :..|..:|      |:|.::..||:.||...|..|
pombe  1348 VNSSLL-PLMQSPLVFCLRKNDANDLDVILSVCNL------LSPFEVVCLLNRYQPCAGENP--- 1402

Human   885 WDPPPAEREAVD-----------TGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELR 935
              .|.:..:||:           |.....:.:.|   .:|:.:|:..|.. :.::.::.|||
pombe  1403 --LPKSFSKAVEALSCKYKQSGFTNGKITNTNGH---AIPIAASKNPLLS-LENNHIYEELR 1458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASIP1	NP_060275.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..118
		RA	144..258	CDD:279168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..356
		Myo5p-like_CBD_Rasip1	551..913	CDD:271256	56/298 (19%)
myo51	NP_596233.1	COG5022	1..1471	CDD:227355	62/322 (19%)
		MYSc_Myo5	79..737	CDD:276831
		IQ	799..820	CDD:197470
		Myo5p-like_CBD_fungal	1068..1447	CDD:271258	59/308 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900