DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RASIP1 and myo52

DIOPT Version :9

Sequence 1:	NP_060275.2	Gene:	RASIP1 / 54922	HGNCID:	24716	Length:	963	Species:	Homo sapiens
Sequence 2:	NP_588492.1	Gene:	myo52 / 2538846	PomBaseID:	SPCC1919.10c	Length:	1516	Species:	Schizosaccharomyces pombe

Alignment Length:	278	Identity:	56/278 - (20%)
Similarity:	98/278 - (35%)	Gaps:	68/278 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   577 TLLALCVQHSARELE-LGHLPRLLGRLARLIKEAVW-----EKIKEIGDRQPENHPEGVPEVPLT 635
            ||..|.::.:..|.: |.||  .|.:|..:|...:|     ::...:.:|...:..|.|.:
pombe  1117 TLKTLLLKDNDVEAQKLDHL--FLAKLLFIIISQMWKSNLCQESVALVERYCVHTLEYVFQ---- 1175

Human   636 PEAVSVELRP-LMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLD----EV 695
             :..|...|| :..|:|||..||:||..|....:..:                |..||.    |.
pombe  1176 -KTSSANERPDIGFWVANTHALLAFVYTKQQAFKHSS----------------AFTLLSTESHES 1223

Human   696 IMCTFQQSVYYLTKTLYSTL--------PALLDSNPFTAGAELPGPGAELGAMPPGLR------- 745
            :...|:....:|:|..:..:        |.::.:...|      |...:.|.....||
pombe  1224 VQTIFEMIESHLSKIFFEWVRQVNNFLKPLIVQAMIIT------GTNTDAGDENRKLRIKFFEKP 1282

Human   746 --PTLGVFQAALELTSQCELHP---DLVSQTFGYLFFFSNASLLNSLM--ERGQGRPFYQWSRAV 803
              ....|.....::...|:.:.   ::.:.....::.|.|....|||.  |||      .|.|..
pombe  1283 KYKITDVIHVLNKVHDSCQAYKVNYEIYNALIRSIYRFINVEAFNSLFIDERG------SWKRGT 1341

Human   804 QIRTNLDLVLDWLQGAGL 821
            .|..|..::.||...:|:
pombe  1342 NISYNYHVLKDWCLESGV 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASIP1	NP_060275.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..118
		RA	144..258	CDD:279168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..356
		Myo5p-like_CBD_Rasip1	551..913	CDD:271256	56/278 (20%)
myo52	NP_588492.1	COG5022	1..1501	CDD:227355	56/278 (20%)
		MYSc_Myo5	87..754	CDD:276831
		Myo5p-like_CBD_fungal	1105..1434	CDD:271258	56/278 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900