DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAAF5 and HEATR2

DIOPT Version :9

Sequence 1:	NP_060272.3	Gene:	DNAAF5 / 54919	HGNCID:	26013	Length:	855	Species:	Homo sapiens
Sequence 2:	NP_731905.1	Gene:	HEATR2 / 318680	FlyBaseID:	FBgn0051320	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	859	Identity:	209/859 - (24%)
Similarity:	360/859 - (41%)	Gaps:	149/859 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    33 RLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAEGCRALAV 97
            ::...||:..:..:...|:.|....:|...:.........:.:|.| .||:|..|..|..|:.|:
  Fly     9 KICSDLESSDRRLKTTVLDELLDKCKEATNSESADKIADVFDKLYL-HLLKCYEDRFESVRSKAI 72

Human    98 HLLDLGLRRAARPRD-ALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALA 161
            .::...| .:..|.| .|..::..||.|:.    .....|..||:||..:..|.|.:     .|.
  Fly    73 QVVSAFL-SSLPPTDFHLMNVVSTLAERMG----KAETVEPSEEIRLLYIAQLNLMI-----CLY 127

Human   162 PHLDD----------ALRALRCSLLDPFAAVRRESCSCAAALAQ-ATPDHFHMQSESLIGPLMQT 215
            ..:::          .::.|..|:.|.:..|:||.||....|:: |....|...:||::.||...
  Fly   128 EKMENVGVFRECYPLVVKILIKSIKDDYPVVQREGCSAVVTLSRLADTQEFRPFTESILLPLYTM 192

Human   216 ISHQHWKVRVAAIEATGAV-IHF-GNGKSVDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRD 278
            ::|:|.:.|::||:|...: :|. .:|.::..:.:..:..|.|.:|.|||.|..:....|:.|.|
  Fly   193 LNHKHAQARISAIQAIARLSLHMDASGDAMRRLFNEVSPLLMDTMPLVRREVGQMGILMLMELLD 257

Human   279 RYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDVGLQWQKENEEDLKDKLDFAPPTPPHYPPHER 343
            |||||.:::||:|..|.||.|||.......|...|:|:..|||.:|..: :.:.....:||...:
  Fly   258 RYSFFERILPLVLCCLKDESPEVLNHIYPQWLKCGIQYFNENEAELSQQ-EISDLPVENYPKDVK 321

Human   344 RPVLGCRELVFRNLSKILPALCHDITDWVVGTRVKSAQLLPVLLLHAEDHATQHLEVVLRTLFQA 408
            ||.:|||.||.|:| ::|..:..:.:||....|:.:.:||...:||||...|.....:...|..|
  Fly   322 RPTIGCRGLVQRSL-RLLQLITRETSDWKDNVRLHALKLLYQFVLHAEAAMTAKFFEIYGDLAHA 385

Human   409 CTDEEAAVVQSCTRSAELVGTFVSPEVFLKLILSTLKK--------------TPSASG----LLV 455
            |.|..|.|.....:.|:|:|..:|.:.::......|::              |.|..|    |:.
  Fly   386 CIDHVAEVNAEAAKVADLMGRLLSYDAWIDHGFDGLERNARESYMRCFYHMFTASLGGTYEQLMR 450

Human   456 LASAMRGCP--REALQP---H-----LAAIATELAQAHICQASENDLYLERLLLC---VQALVS- 506
            ||..:| |.  ...|:|   |     |..|..:..:.:..|....||| |.:.:|   |.||.|
  Fly   451 LAKLLR-CTDYSHTLKPGFQHYILKLLNTIVDKTLKINAGQNELEDLY-ESVYVCAIKVMALSSS 513

Human   507 ---VCHEDCGVASL---QLLDVLLTIV----------ALAGATGLRDKAQETMDSLAMVEG-VSS 554
               |..||......   :::.:|.|.|          ||.....|....::..:.:.::.| ::.
  Fly   514 LENVGDEDVNFGQTLIEKMVKLLNTSVPKIHERWFHLALQDVINLDAALEDNAEPVMLLNGLINM 578

Human   555 CQDLYRKHIGPLLERVTASHLDWTAHSPELLQFSVIVAQSGPALGEALPHVVPTLRACLQPSQDP 619
            |      ||     |.|..|        :|::...||.|.                 |...:|
  Fly   579 C------HI-----RATYVH--------DLIEKVKIVFQH-----------------CCDSAQ-- 605

Human   620 QMRLKLFSILSTVLLRATDTINSQGQFPS-YLETVTKDILAPNLQWHAGRTAAAIRTAAVSCLWA 683
               :|:||.||...|..:.|:|.:.:..: .|......|:.|.|.|.||..|.|:|:.|::.|.|
  Fly   606 ---VKIFSSLSLATLFWSKTMNVERESSTQMLSEFVSQIVEPYLTWKAGSNAEAMRSLAMATLCA 667

Human   684 LTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKMTRLISCRIINTFLKTSGGMTDPEKLIRIYPEL 748
            |.......:.::.......||.:   ||:.:..||..:.:.:..|.:.|     .|.|..:....
  Fly   668 LAQGAESESVEVLPSLAKYMPSL---LEDRNVTTRHYAIKAVVYFREMS-----VEDLKPLAYAT 724

Human   749 LKRLDDVSNDVRMAAASTLVTWLQCVKGANAKSYYQSSVQYLYRE-------------LLVHLDD 800
            ::|:||.|..:|:.||..:        |.....:.::..:..|.:             ||::.:.
  Fly   725 MQRMDDPSAGIRILAALAM--------GKLKPKFAETDTEENYEKEVWDAIVKRAMDLLLLYHES 781

Human   801 PERAIQDAILEVLK 814
            ||:.::.|:...||
  Fly   782 PEKDMRAAVAVTLK 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAAF5	NP_060272.3	HEAT 1	71..109		10/37 (27%)
		HEAT repeat	166..192	CDD:293787	8/35 (23%)
		HEAT 2	202..240		11/39 (28%)
		HEAT 3	241..278		9/36 (25%)
		HEAT repeat	246..274	CDD:293787	7/27 (26%)
		HEAT 4	280..318		16/37 (43%)
		HEAT repeat	285..315	CDD:293787	11/29 (38%)
		HEAT 5	354..376		5/21 (24%)
		HEAT repeat	359..385	CDD:293787	6/25 (24%)
		HEAT 6	377..414		11/36 (31%)
		HEAT 7	599..638		8/38 (21%)
		HEAT 8	696..734		8/37 (22%)
		HEAT repeat	701..731	CDD:293787	7/29 (24%)
		HEAT 9	738..776		9/37 (24%)
		HEAT repeat	740..772	CDD:293787	8/31 (26%)
		HEAT repeat	783..813	CDD:293787	6/42 (14%)
		HEAT 10	784..822		8/44 (18%)
HEATR2	NP_731905.1	HEAT repeat	52..80	CDD:293787	10/29 (34%)
		HEAT repeat	91..124	CDD:293787	10/36 (28%)
		HEAT repeat	143..174	CDD:293787	9/30 (30%)
		HEAT repeat	184..214	CDD:293787	9/29 (31%)
		HEAT repeat	224..254	CDD:293787	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157582
Domainoid	1	1.000	113	1.000	Domainoid score	I6121
eggNOG	1	0.900	-	-		E1_2CMTW
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41198
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4216
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56744
OrthoDB	1	1.010	-	-		D123510at2759
OrthoFinder	1	1.000	-	-		FOG0007268
OrthoInspector	1	1.000	-	-		oto89076
orthoMCL	1	0.900	-	-		OOG6_104125
Panther	1	1.100	-	-	LDO	PTHR16216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5174
SonicParanoid	1	1.000	-	-		X5373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800