DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAAF5 and dnaaf5

DIOPT Version :9

Sequence 1:	NP_060272.3	Gene:	DNAAF5 / 54919	HGNCID:	26013	Length:	855	Species:	Homo sapiens
Sequence 2:	XP_009302392.3	Gene:	dnaaf5 / 100333660	-ID:	-	Length:	849	Species:	Danio rerio

Alignment Length:	854	Identity:	409/854 - (47%)
Similarity:	582/854 - (68%)	Gaps:	25/854 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     8 EAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGP 72
            ||..|   |.|.:.| |.::.::|:|.|..|..|:|..|:|||||:||...|...::.  |.|..
Zfish    11 EAAMA---AAGDDRA-AADVLKSLARHLNCLNDDNKSARKRALEAVRRETVEQRLSSG--AMQEL 69

Human    73 WARLLLPRLLRCLSDPAEGCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEA 137
            ...||.| ||:|||||||.||..::.::...:|...:|.|.||.|:||||.||.|    :...|.
Zfish    70 LGCLLKP-LLKCLSDPAETCRDASIQIIVGFIRAVPKPEDCLPYLMPALAQRLGG----KEILEP 129

Human   138 CEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFAAVRRESCSCAAALAQATPDHFH 202
            .|||||||:::|.|.|::||..:||:|:|.::.|:.::.||||.|::|||.|..::||..|:|||
Zfish   130 AEELRLALMEMLSLLVEVCGKQIAPYLEDLIKILQRTISDPFAEVKKESCKCTVSVAQCIPEHFH 194

Human   203 MQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQVRRAVAS 267
            :|:|||:.||:|||||||.:|||:|.:|.||||.:..||:||:||||.|||||||.|:||:||..
Zfish   195 LQAESLLKPLLQTISHQHSQVRVSATQAIGAVIQYSAGKNVDEVLSHLAQRLFDDSPRVRKAVTL 259

Human   268 VVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDVGLQWQKENEEDLKDKLDFAP 332
            |||.|||.|.||||:|||||||||:|::||:||:|.||.:.|:.||.||:||||:|||||:||..
Zfish   260 VVGDWLLRLPDRYSYFHKLIPLLLTSVSDEIPEIRSLAENSWKQVGAQWEKENEDDLKDKMDFQL 324

Human   333 PTPPHYPPHERRPVLGCRELVFRNLSKILPALCHDITDWVVGTRVKSAQLLPVLLLHAEDHATQH 397
            |.|..|.....||.|||||||.|||||:|||:..||.||:|.||||:.|||.|||||||||.|||
Zfish   325 PAPALYTSGGERPGLGCRELVVRNLSKLLPAMGRDIGDWLVQTRVKTVQLLRVLLLHAEDHCTQH 389

Human   398 LEVVLRTLFQACTDEEAAVVQSCTRSAELVGTFVSPEVFLKLILSTLKKTPSASG------LLVL 456
            |:::|..|:.||.|.|..|...|..||:|:|.||||||:|||:|..::.:.|.|.      |:||
Zfish   390 LQMLLTVLYHACADAETDVRTQCLESAKLLGVFVSPEVYLKLLLPHVEDSSSCSSASPWAPLMVL 454

Human   457 ASAMRGCPREALQPHLAAIATELAQAHICQASENDLYLERLLLCVQALVSVCHEDCGVASLQLLD 521
            .:.:.|..||.|:|||..|...|||..:|..|:..||:::||:||.|::.|..:||.|.|||||.
Zfish   455 GAVLSGSSRETLRPHLVKIGDTLAQPEVCLGSQQVLYVDQLLVCVDAVLGVGQQDCDVISLQLLK 519

Human   522 VLLTIVALAGATGLRDKAQETMDSLAMVEGVSSCQDLYRKHIGPLLERVTASHLDWTAHSPELLQ 586
            ||:::.::|.......||:|.:.|:...:.:|...||||:|:..||:.::.||..||:.|.:..|
Zfish   520 VLVSVQSVASQHEQHSKAEELLRSVCAAQALSGVCDLYRQHMADLLQWLSDSHQTWTSFSIQKTQ 584

Human   587 FSVIVAQSGPALGEALPHVVPTLRACLQPSQDPQMRLKLFSILSTVLLRATDTINSQGQFPSYLE 651
            ..:|..||||.:||.||.::|.|::|:.||::|:|||.:|::||.:||.|.:|::|||||..::|
Zfish   585 LEIIAMQSGPVVGEFLPALLPLLKSCVDPSREPEMRLHIFTMLSKLLLDAKNTLDSQGQFGEHME 649

Human   652 TVTKDILAPNLQWHAGRTAAAIRTAAVSCLWALTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKM 716
            .|.:|:|.|||.|.:||:|||:||||:|||.|:...|...||::....::|...:::.||||||:
Zfish   650 MVLQDLLMPNLVWRSGRSAAAVRTAALSCLLAVLHGEAFPAERVVSAVDSLSSLLISALEEDSKL 714

Human   717 TRLISCRIINTFLKTSGGMTDPEKLIRIYPELLKRLDDVSNDVRMAAASTLVTWLQCVKGANAKS 781
            .||::||.:.:.||.:......:||.::|||||||:||.|.|||:.|..:|..|. |..|   |:
Zfish   715 ARLLACRSLTSLLKITAQQISTDKLNQVYPELLKRVDDSSEDVRVEALKSLSVWF-CSLG---KN 775

Human   782 YYQSS----VQYLYRELLVHLDDPERAIQDAILEVLKEGSGLFPDLLVRETEAVIHKHRSATYCE 842
            |...|    ::.|:::||:::|||:..:|:.:|.|||..|.:..|||.::||:|..|.||..||:
Zfish   776 YDMQSNRPHLELLFQQLLLYMDDPDTTVQNTVLGVLKVASAVDGDLLQQQTESVREKQRSPEYCD 840

Human   843 QLLQHVQAV 851
            :||||:.::
Zfish   841 KLLQHIHSL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAAF5	NP_060272.3	HEAT 1	71..109		15/37 (41%)
		HEAT repeat	166..192	CDD:293787	11/25 (44%)
		HEAT 2	202..240		23/37 (62%)
		HEAT 3	241..278		26/36 (72%)
		HEAT repeat	246..274	CDD:293787	20/27 (74%)
		HEAT 4	280..318		24/37 (65%)
		HEAT repeat	285..315	CDD:293787	18/29 (62%)
		HEAT 5	354..376		13/21 (62%)
		HEAT repeat	359..385	CDD:293787	16/25 (64%)
		HEAT 6	377..414		23/36 (64%)
		HEAT 7	599..638		19/38 (50%)
		HEAT 8	696..734		13/37 (35%)
		HEAT repeat	701..731	CDD:293787	12/29 (41%)
		HEAT 9	738..776		19/37 (51%)
		HEAT repeat	740..772	CDD:293787	18/31 (58%)
		HEAT repeat	783..813	CDD:293787	9/33 (27%)
		HEAT 10	784..822		13/41 (32%)
dnaaf5	XP_009302392.3	HEAT repeat	114..139	CDD:293787	15/28 (54%)
		HEAT repeat	159..187	CDD:293787	10/27 (37%)
		HEAT repeat	199..229	CDD:293787	20/29 (69%)
		HEAT repeat	237..263	CDD:293787	18/25 (72%)
		HEAT repeat	351..377	CDD:293787	16/25 (64%)
		HEAT repeat	390..415	CDD:293787	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41198
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123510at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010