Protein Alignment TTC19 and RTC4

DIOPT Version :10

• Sequence 1: NP_060245.3
• Gene: TTC19 / 54902
• HGNCID: 26006
• Length: 380
• Species: Homo sapiens
• Sequence 2: NP_014145.1
• Gene: RTC4 / 855467
• SGDID: S000005198
• Length: 401
• Species: Saccharomyces cerevisiae
• Alignment Length: 295
• Identity: 56/295 - (18%)
• Similarity: 99/295 - (33%)
• Gaps: 106/295 - (35%)

Human    60 LAALAWFSRPAAA-EEEEQQGADGAAAEDGADEAEAEII-------------------------- 97
            |:.:|.|.:.:.: ...|.|.|..||.. |.::.|.:::
Yeast    74 LSTVATFDKLSRSFPNSEVQAAKNAALR-GKEKEEEKVVSIPLIQNLKNEDIESIKCRNNNLLDG 137

Human    98 -QLLKRAKLSIMKDE-------PEEAELILHDALRLAYQTDNKKAITYTYDLMAN-----LAFIR 149
             :||..|:||.::|.       ||:.:|.|...|....|...|..:...|  |:.     :.|..
Yeast   138 KKLLLEAELSAVEDNQIFSSSFPEDKKLSLQSCLSSKEQIIKKLQVREEY--MSKFKLPPMLFSD 200

Human   150 GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIY------AAQNRQEFAVAGYEFCIST 208
            ..|...|......|..|.|               |::|:|      |.:|.|:..::..||....
Yeast   201 ELLTEVEPFMPIVMDILEG---------------KISSVYYFEAKNAFKNSQKAYLSVDEFRKLN 250

Human   209 LEE------KIEREKELAEDIMSVEEKANTH----------------------LLLGMCL----- 240
            |.:      .::|:..:.|:|....::|.||                      .|...|:
Yeast   251 LNKFTAGFYGLKRQLRVGEEIAKRYKRALTHNQPATLKWWGITDFCNYVLAPETLTSFCIYQLNL 315

Human   241 --DACARYLLFSKQPSQ--AQRMYEKALQISEEIQ 271
              .:|:     ||.|::  .|::.||......|::
Yeast   316 SNKSCS-----SKTPNKHPKQQLNEKEYYYDPELR 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTC19	NP_060245.3	LapB	102..348	CDD:442196	44/225 (20%)
		TPR 1	136..169		7/37 (19%)
		TPR 2	179..212		9/44 (20%)
		Spy	227..>348	CDD:443119	13/76 (17%)
		TPR 3	237..270		8/41 (20%)
		TPR repeat	278..308	CDD:276809
		TPR 4	279..312
		TPR 5	318..351
		TPR repeat	318..346	CDD:276809
RTC4	NP_014145.1	RTC4	218..364	CDD:464184	26/148 (18%)