Protein Alignment TTC19 and Ttc19

DIOPT Version :10

• Sequence 1: NP_060245.3
• Gene: TTC19 / 54902
• HGNCID: 26006
• Length: 380
• Species: Homo sapiens
• Sequence 2: NP_082636.3
• Gene: Ttc19 / 72795
• MGIID: 1920045
• Length: 365
• Species: Mus musculus
• Alignment Length: 375
• Identity: 309/375 - (82%)
• Similarity: 334/375 - (89%)
• Gaps: 10/375 - (2%)

Human     1 MFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPLLAALAW 65
            |||||.|.|||..||||||||.||:|||||...|..|...:...:|.|| .||.|:|||||||||
Mouse     1 MFRLLRWRLGRTLLRAAGRRCGGCTARLLPERTGDAGTGAERLRTRGAP-ARGHGVLPLLAALAW 64

Human    66 FSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTD 130
            ||||||..|:        ..||.:||||||||||||:|||||||||||.|||||||||||||::|
Mouse    65 FSRPAATAEQ--------PGEDASDEAEAEIIQLLKQAKLSIMKDEPEAAELILHDALRLAYESD 121

Human   131 NKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQ 195
            |:||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||:|
Mouse   122 NRKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLANIYAAQNKQ 186

Human   196 EFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMY 260
            |||:|||||||||||.|||||||||||||| ||.|||:||||||||:||||||||||.|||||||
Mouse   187 EFALAGYEFCISTLEGKIEREKELAEDIMS-EETANTYLLLGMCLDSCARYLLFSKQLSQAQRMY 250

Human   261 EKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLA 325
            ||||||.:|||||||||||||||||||||||||.||:|||||||||||||:||||||||||||||
Mouse   251 EKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAYIYMQRASDLAREINHPELHMVLSNLA 315

Human   326 AVLMHRERYTQAKEIYQEALKQAKLKKDEISVQHIREELAELSKKSRPLT 375
            |:|:|||||||||||||||||:|:||:||:|||||||||||||:|||.||
Mouse   316 AILIHRERYTQAKEIYQEALKRAELKRDEVSVQHIREELAELSRKSRRLT 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTC19	NP_060245.3	LapB	102..348	CDD:442196	224/245 (91%)
		TPR 1	136..169		32/32 (100%)
		TPR 2	179..212		29/32 (91%)
		Spy	227..>348	CDD:443119	109/120 (91%)
		TPR 3	237..270		28/32 (88%)
		TPR repeat	278..308	CDD:276809	27/29 (93%)
		TPR 4	279..312		30/32 (94%)
		TPR 5	318..351		28/32 (88%)
		TPR repeat	318..346	CDD:276809	25/27 (93%)
Ttc19	NP_082636.3	TPR 1	127..160		32/32 (100%)
		Spy	163..>338	CDD:443119	159/175 (91%)
		TPR 2	220..260		34/39 (87%)
		TPR repeat	220..255	CDD:276809	31/34 (91%)
		TPR repeat	268..298	CDD:276809	27/29 (93%)
		TPR 3	269..302		30/32 (94%)
		TPR 4	308..341		28/32 (88%)
		TPR repeat	308..336	CDD:276809	25/27 (93%)