Protein Alignment TTC19 and ttc19

DIOPT Version :10

• Sequence 1: NP_060245.3
• Gene: TTC19 / 54902
• HGNCID: 26006
• Length: 380
• Species: Homo sapiens
• Sequence 2: XP_002938292.3
• Gene: ttc19 / 100485992
• XenbaseID: XB-GENE-6258121
• Length: 399
• Species: Xenopus tropicalis
• Alignment Length: 392
• Identity: 176/392 - (44%)
• Similarity: 249/392 - (63%)
• Gaps: 30/392 - (7%)

Human     7 WSL---GRGFLRAAG----RRCRGCSARLLPGLAGGPGPE------VQVPPSRVAPHGRGPGLLP 58
            |.:   |...||..|    |||..|.|:.........|..      ..:.|.|:......|  .|
 Frog    11 WEMFFHGGKMLRNTGVCLYRRCVSCVAQRARNHCQQAGERTSWVAAASIRPKRITVSTSRP--FP 73

Human    59 LLAALAWFSRPAAAEEEEQQGADGAAA-----------EDGADEAEAEIIQLLKRAKLSIMKDEP 112
              :.|..|.:...:|.........|||           |:...|||.:||.|||:|||||||.|.
 Frog    74 --SCLVTFGKKRVSEGCRDLSFVMAAAAFSLFSYFGEKEEEVTEAEQDIILLLKKAKLSIMKGEM 136

Human   113 EEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNA 177
            ||||.|||.||.:|:::.:.:||.||||||||||.:.|:|:.:|:|||.|:.::|...::|:|||
 Frog   137 EEAEEILHQALNMAHKSGSTRAIIYTYDLMANLALLTGKLDTSEKLFKETLIFMLNDNIQQDDNA 201

Human   178 IIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDA 242
            .||||||||||||.||::|.|||||:|||.:||||:|::..|.|..::.:||:||.||||:|||:
 Frog   202 FIEISLKLASIYATQNKKELAVAGYQFCILSLEEKLEKQAGLLEGSLAADEKSNTRLLLGLCLDS 266

Human   243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASD 307
            ..|||:.:...||||.||||||:|..|.||..|||:::||:|:|..|:|.|:.|||:..:.:||:
 Frog   267 YGRYLINNSSFSQAQNMYEKALRICTEEQGTEHPQSVILMNDIAIALEALGKHDEAFAIVNQASE 331

Human   308 LARQINHPELHMVLSNLAAVLMH--RERYTQAKEIYQEALKQAKLKKDEISVQHIREELAELSKK 370
            |||:..||:||:||||||.:|.:  :|.:.:|:.|::|||:.::.|.|..|||:|:|.||||.::
 Frog   332 LARKTEHPDLHVVLSNLAMILTYQGKEHFAEAERIFKEALEHSEKKGDSASVQYIQEGLAELDRR 396

Human   371 SR 372
            .:
 Frog   397 KK 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTC19	NP_060245.3	LapB	102..348	CDD:442196	135/247 (55%)
		TPR 1	136..169		18/32 (56%)
		TPR 2	179..212		25/32 (78%)
		Spy	227..>348	CDD:443119	63/122 (52%)
		TPR 3	237..270		18/32 (56%)
		TPR repeat	278..308	CDD:276809	12/29 (41%)
		TPR 4	279..312		15/32 (47%)
		TPR 5	318..351		14/34 (41%)
		TPR repeat	318..346	CDD:276809	13/29 (45%)
ttc19	XP_002938292.3	BepA	<118..227	CDD:443813	66/108 (61%)
		Spy	220..>373	CDD:443119	79/152 (52%)
		TPR repeat	302..332	CDD:276809	12/29 (41%)
		TPR repeat	342..372	CDD:276809	13/29 (45%)