DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNF43 and znrf3

DIOPT Version :10

Sequence 1:NP_001425749.1 Gene:RNF43 / 54894 HGNCID:18505 Length:869 Species:Homo sapiens
Sequence 2:NP_001295484.1 Gene:znrf3 / 556813 ZFINID:ZDB-GENE-070705-263 Length:866 Species:Danio rerio


Alignment Length:642 Identity:214/642 - (33%)
Similarity:299/642 - (46%) Gaps:138/642 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    17 LMATLQAGFGRTG----LVLAAAVESERSAEQKAIIRVIPLKMDPTG---KLNLTLEGVFAGVAE 74
            :|...:.||||..    |||...:.|. .|:..|.:.|:..:..|.|   .....|:|.|:....
Zfish     1 MMILPRTGFGRGADSVVLVLLWVLGSV-LAKDTAFVEVVLFESSPNGDYTTYTTGLQGRFSRAGA 64

Human    75 ITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVL 138
            ...|||:::|.|||.|||.:|:::| |.|::.:||||.|...| .||::..||:.|.:|||:||:
Zfish    65 TISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDP-SCLTVLGKAKRAVQRGATAVI 128

Human   139 FDITEDRAAAEQLQQ----PLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDV 199
            ||::|:..|.:||.|    |  |..|||.:.|.||.|||..|.|.:.|..||:.:.|.....:|:
Zfish   129 FDVSENPDAIDQLNQVSEDP--LKRPVVYVKGTDAVKLMNIVNKQKVARARIQHRPPRPTEYFDM 191

Human   200 WILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASC---RQARGEWPD 261
            .|.:.....:.::.|..:::|:.:.|.|: ..:.:....|:.::.|.:::|..   |:|.....|
Zfish   192 GIFLAFFVVVSLVCLILLIKIKLKQRRSQ-SSMNRMAIQALEKMETCKFKAKFKGQREASCGASD 255

Human   262 SGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSL 326
            |.|| ||...||||||::.:|:|||||.|.|.||:.||||||.||.|||.|..||.:     |..
Zfish   256 SVSS-SSTSDCAICLEKYIDGEELRVIPCAHRFHKKCVDPWLLQHHTCPHCRHNIID-----QKK 314

Human   327 G-PSRSYQEPGRRLHLIRQ-------HPGHAH-YHLPAAYLLGPSRSA------------VARPP 370
            | |.....:||..:|..:|       :||..| .....||   |:|::            |.:.|
Zfish   315 GNPGAVCLDPGNPVHGRQQRVVLPVHYPGRVHRAGQVTAY---PTRTSMDPHGNPITVLTVDQHP 376

Human   371 RPGPFLPSQ------------EPGMGPRH----HRFPRAAHP----------------RAPGEQQ 403
            ..|.: |||            :..:.|.|    ||.|  |:|                ||....|
Zfish   377 EQGLY-PSQSSFIRGYPALHLDHTLNPHHCGLEHRGP--AYPQTHTFKRPKFHGRNFSRAACFSQ 438

Human   404 RLAGAQHPYAQGW-----------GLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTER--- 454
            .....||.|.||.           ||....:....|......:....|..||..|:|..|..   
Zfish   439 YETMYQHYYFQGLTFPQPEGQPSNGLHKGHNRPFQPGLLYPTVVHMAPASSSRLGDSGSTSGLSC 503

Human   455 --------SGYLADGPASD--SSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLV 509
                    ||||||.|.||  ||||.||.|||||:::||::|.|||:||.|||.||||||:||.|
Zfish   504 YHGHRSVCSGYLADCPGSDSSSSSGQCHCSSSDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYV 568

Human   510 Y------------------CSPKGDPQRVDMQPSVTSRPRS--LDSVVPTGETQVSS 546
            |                  .:|..|.         ||.|.|  :|.:.|.|....||
Zfish   569 YRSKSPCRGSAGEAGAVFSAAPPADD---------TSAPVSGMIDCLQPPGGACYSS 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNF43NP_001425749.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..406 17/86 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..477 24/68 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..673 10/35 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..760
znrf3NP_001295484.1 ZNRF_3_ecto 75..180 CDD:408039 49/107 (46%)
RING-H2_ZNRF3 264..308 CDD:319713 28/43 (65%)
HRD1 <265..470 CDD:227568 67/215 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..811
Blue background indicates that the domain is not in the aligned region.

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