Protein Alignment RNF43 and znrf3

DIOPT Version :9

• Sequence 1: XP_011523257.1
• Gene: RNF43 / 54894
• HGNCID: 18505
• Length: 869
• Species: Homo sapiens
• Sequence 2: NP_001295484.1
• Gene: znrf3 / 556813
• ZFINID: ZDB-GENE-070705-263
• Length: 866
• Species: Danio rerio
• Alignment Length: 642
• Identity: 214/642 - (33%)
• Similarity: 299/642 - (46%)
• Gaps: 138/642 - (21%)

Human    17 LMATLQAGFGRTG----LVLAAAVESERSAEQKAIIRVIPLKMDPTG---KLNLTLEGVFAGVAE 74
            :|...:.||||..    |||...:.|. .|:..|.:.|:..:..|.|   .....|:|.|:....
Zfish     1 MMILPRTGFGRGADSVVLVLLWVLGSV-LAKDTAFVEVVLFESSPNGDYTTYTTGLQGRFSRAGA 64

Human    75 ITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVL 138
            ...|||:::|.|||.|||.:|:::| |.|::.:||||.|...| .||::..||:.|.:|||:||:
Zfish    65 TISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDP-SCLTVLGKAKRAVQRGATAVI 128

Human   139 FDITEDRAAAEQLQQ----PLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDV 199
            ||::|:..|.:||.|    |  |..|||.:.|.||.|||..|.|.:.|..||:.:.|.....:|:
Zfish   129 FDVSENPDAIDQLNQVSEDP--LKRPVVYVKGTDAVKLMNIVNKQKVARARIQHRPPRPTEYFDM 191

Human   200 WILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASC---RQARGEWPD 261
            .|.:.....:.::.|..:::|:.:.|.|: ..:.:....|:.::.|.:::|..   |:|.....|
Zfish   192 GIFLAFFVVVSLVCLILLIKIKLKQRRSQ-SSMNRMAIQALEKMETCKFKAKFKGQREASCGASD 255

Human   262 SGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSL 326
            |.|| ||...||||||::.:|:|||||.|.|.||:.||||||.||.|||.|..||.:     |..
Zfish   256 SVSS-SSTSDCAICLEKYIDGEELRVIPCAHRFHKKCVDPWLLQHHTCPHCRHNIID-----QKK 314

Human   327 G-PSRSYQEPGRRLHLIRQ-------HPGHAH-YHLPAAYLLGPSRSA------------VARPP 370
            | |.....:||..:|..:|       :||..| .....||   |:|::            |.:.|
Zfish   315 GNPGAVCLDPGNPVHGRQQRVVLPVHYPGRVHRAGQVTAY---PTRTSMDPHGNPITVLTVDQHP 376

Human   371 RPGPFLPSQ------------EPGMGPRH----HRFPRAAHP----------------RAPGEQQ 403
            ..|.: |||            :..:.|.|    ||.|  |:|                ||....|
Zfish   377 EQGLY-PSQSSFIRGYPALHLDHTLNPHHCGLEHRGP--AYPQTHTFKRPKFHGRNFSRAACFSQ 438

Human   404 RLAGAQHPYAQGW-----------GLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTER--- 454
            .....||.|.||.           ||....:....|......:....|..||..|:|..|..
Zfish   439 YETMYQHYYFQGLTFPQPEGQPSNGLHKGHNRPFQPGLLYPTVVHMAPASSSRLGDSGSTSGLSC 503

Human   455 --------SGYLADGPASD--SSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLV 509
                    ||||||.|.||  ||||.||.|||||:::||::|.|||:||.|||.||||||:||.|
Zfish   504 YHGHRSVCSGYLADCPGSDSSSSSGQCHCSSSDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYV 568

Human   510 Y------------------CSPKGDPQRVDMQPSVTSRPRS--LDSVVPTGETQVSS 546
            |                  .:|..|.         ||.|.|  :|.:.|.|....||
Zfish   569 YRSKSPCRGSAGEAGAVFSAAPPADD---------TSAPVSGMIDCLQPPGGACYSS 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	46/103 (45%)
		zf-RING_2	270..312	CDD:290367	27/41 (66%)
znrf3	NP_001295484.1	zf-RING_2	265..306	CDD:290367	27/40 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..811

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920