Protein Alignment RNF43 and gzl

DIOPT Version :9

• Sequence 1: XP_011523257.1
• Gene: RNF43 / 54894
• HGNCID: 18505
• Length: 869
• Species: Homo sapiens
• Sequence 2: NP_001097695.1
• Gene: gzl / 40791
• FlyBaseID: FBgn0037442
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 111/547 - (20%)
• Similarity: 195/547 - (35%)
• Gaps: 160/547 - (29%)

Human    51 IPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDD---NLEPG--FISIVKLE 110
            :|.:..|    ||...|:   ...:.||.      .|.|.|::.|..   ...|.  |:::|
  Fly    45 LPAQFGP----NLPSNGL---KVYVVPAR------RPYYGCDSLDRPPHLKYPPSAKFVALV--- 93

Human   111 SPRRAPRPCLSLASKARMAGERGASAVLFDITE----DRAAAEQLQQPLGLTWPVVLIWGNDAEK 171
                |...|: ...|.|:|.....|||:....|    ::.:||.:   .|:..|.|.: |:...|
  Fly    94 ----ARGECV-FERKIRVAQNASYSAVIVYNNEGDDLEQMSAENI---TGIRIPSVFV-GHTTGK 149

Human   172 LMEFVYKNQKA---------HVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVL--------R 219
            .:...:..:..         ::..:|..|          ...::|..|:|::..::        |
  Fly   150 ALATYFTTEVVLIINDELPFNINTQLILP----------FSILIGMCFIIMVIYMIYKCIREQRR 204

Human   220 IRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQE 284
            :|   ||..|..:       :.:|...||            ...::.:....|.||||:|.|..:
  Fly   205 LR---RHRLPKSM-------LKKLPVLRY------------TKNNANNKYDTCVICLEDFIEDDK 247

Human   285 LRVISCLHEFHRNCVDPWLHQH-RTCPLCMFNI-TEGDS-FSQSLGPS---------------RS 331
            |||:.|.|.:|.:|:||||.:: |.||:|...: |:|:: .|:|..||               :.
  Fly   248 LRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQ 312

Human   332 YQEPGRRLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHP 396
            .|..||::       |.......|....| |.|:||.....|.          .||..|.|....
  Fly   313 QQSNGRQV-------GQVSSASSAGGAAG-SSSSVAAAAVAGT----------TRHGTFRRGHAG 359

Human   397 RAPGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTER------- 454
            |.|.|:.:.:..::.         |.:::..||.......|..|.|.:.:..::..|:
  Fly   360 RNPFEESQSSDDENA---------LLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTESRRS 415

Human   455 -------SGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGV-----HGSSSTFCSSLSSDF-- 505
                   :.:....||..|.:.|.:....:|..:...:.:.|.     ..|::....:||..|
  Fly   416 VWSRINFASFFRRQPAVISVAAPPYLERVESGTSAMGLPVTGTIAVASPASNNILNPNLSGSFKD 480

Human   506 -----------DPLVYCSPKGDPQRVD 521
                       :|:...:|..|...||
  Fly   481 EDDMPPHRSIYEPIAISTPAADSATVD 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	23/116 (20%)
		zf-RING_2	270..312	CDD:290367	21/42 (50%)
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	30/150 (20%)
		zf-RING_2	233..277	CDD:290367	21/43 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920