DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF43 and Rnf43

DIOPT Version :9

Sequence 1:	XP_011523257.1	Gene:	RNF43 / 54894	HGNCID:	18505	Length:	869	Species:	Homo sapiens
Sequence 2:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	644/791 - (81%)
Similarity:	683/791 - (86%)	Gaps:	14/791 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTL 65
            ||||||||||.||||||||||.||||.||||||||||||||||||||||||||||||||||||||
  Rat     1 MSGGHQLQLAVLWPWLLMATLHAGFGHTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTL 65

Human    66 EGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAG 130
            |||||||||::||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 EGVFAGVAEVSPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAG 130

Human   131 ERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWP 195
            |||||||||||||||:||||||||||||.|||||||:||||||||||||:||:|.|||||||||.
  Rat   131 ERGASAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWA 195

Human   196 DYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWP 260
            :||||||:|||||:|||||||||||||||..|||||||||||.|||||||||||||||:||.|||
  Rat   196 NYDVWILLTVVGTVFVIILASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWP 260

Human   261 DSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQS 325
            |||||.|||||||||||||:||||||||||||||||.|||||||||||||||||||.|||||||:
  Rat   261 DSGSSSSSAPVCAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGDSFSQA 325

Human   326 LGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRF 390
            ||.|.||||||||||||||||||||||||:||||||||::||:.|||.||||||||.||.||.|.
  Rat   326 LGASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRNSVAQTPRPRPFLPSQEPSMGSRHQRL 390

Human   391 PRAAHPRAPGEQQRLA-GAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTER 454
            |||:|.|||.|||.|| ...||||||||.:.|:.|||||.||||.||||||.:||||||||||||
  Rat   391 PRASHLRAPEEQQHLAVSPGHPYAQGWGPNRLRCTSQHPNACPVALRRARPHESSGSGESYCTER 455

Human   455 SGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQR 519
            |||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||:|..|.
  Rat   456 SGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDPLVYCSPEGALQG 520

Human   520 VDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPR 584
            .::|||:|||||||||||||||||||||:||||||||||||:||||.||||.|||||||||....
  Rat   521 KEVQPSMTSRPRSLDSVVPTGETQVSSHIHYHRHRHHHYKKQFQWHSRKPGLETGVPQSRPAASH 585

Human   585 TQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTS-SLFNLQKSSLS 648
            |  |.||..||||:|..|.|. |..|.|||.||||.|||||..:|.|..||.: ||.|||||:|.
  Rat   586 T--QLEPSLPDQQLTTPNPAV-SSMLPNPQRPRALTEPAPGLAEAVSPSPSPNPSLLNLQKSNLP 647

Human   649 ARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPE 713
            .|:|||||||||||..|.|:|||.|||.||.:.|||:||:||||.||.||||..|||||:|||.:
  Rat   648 VRYPQRKRRGGPSEALPTSQPQDLTVHTACPVPPHYSPSLAYPWPPEVHPLIFRPPGLDRRLLHD 712

Human   714 TPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEG--- 775
            .||||||:||||||.|.|||||.|..||||.|:||.||.|.|.|||.|||||.|||||.|..
  Rat   713 VPGPCYSSSQPVWLYLNPRQPLGPCLPGEGHSKWSFDTPEDRRCPYSHCQVLPAQPGECSGKQVF 777

Human   776 ------SGCGR 780
                  |||.|
  Rat   778 WEKETISGCWR 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	93/98 (95%)
RNF43	XP_011523257.1	zf-RING_2	270..312	CDD:290367	39/41 (95%)
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	95/101 (94%)
		RING-H2_RNF43	270..316	CDD:319712	43/45 (96%)
		dnaA	598..>743	CDD:237605	96/145 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83694063
Domainoid	1	1.000	734	1.000	Domainoid score	I3224
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37742
Inparanoid	1	1.050	1319	1.000	Inparanoid score	I3483
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38388
OrthoDB	1	1.010	-	-		D109650at7742
OrthoFinder	1	1.000	-	-		FOG0013512
OrthoInspector	1	1.000	-	-		oto143939
orthoMCL	1	0.900	-	-		OOG6_118517
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.370