DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF43 and SPBP4H10.07

DIOPT Version :9

Sequence 1:	XP_011523257.1	Gene:	RNF43 / 54894	HGNCID:	18505	Length:	869	Species:	Homo sapiens
Sequence 2:	NP_596181.1	Gene:	SPBP4H10.07 / 2541304	PomBaseID:	SPBP4H10.07	Length:	583	Species:	Schizosaccharomyces pombe

Alignment Length:	340	Identity:	77/340 - (22%)
Similarity:	116/340 - (34%)	Gaps:	109/340 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    18 MATLQAGFGRTGLVLAAAVESE-RSAEQKAIIRVIPLKMDPTGKLNL-----------TLEG--- 67
            ::.|.||    .||.|...|:. |:||  .|...:.|: :.:|.:||           ..||
pombe   292 LSLLHAG----NLVQAMNAETNPRTAE--LIANAVDLE-EESGPINLFRTFRFDNLHRNHEGQEV 349

Human    68 ---VFAGVAEI---------TPAEGKLMQSHPLYLCNA---------SDDDNLEPGFISIVKLES 111
               :..|:..:         .|:.......||..|.::         |..||..|.       |:
pombe   350 IPIIIVGIRSLRNSGSDEDDQPSADSPTLMHPSDLISSLVNSQNQTTSVSDNTGPN-------EN 407

Human   112 PRRAPRPCLSLASKARMAGE-------RGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDA 169
            ...|..  :|...:|..|.:       .|:|..  ...|.|....|....|..:|   .|:..:|
pombe   408 VNEAEH--ISEDEQASTATDVNGISDNNGSSTQ--QAPETRNNNSQTDHQLPRSW---AIYVREA 465

Human   170 EKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQ 234
                 ||.:|...     |:.|..:.|...:..|        ::|.|::.|...|..|:.|
pombe   466 -----FVPQNHPV-----LRAPSLFTDSPTYEDM--------LLLNSIIGIEKPPVASQKD---- 508

Human   235 RTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVI-SCLHEFHRNC 298
                             ..:|.|.:|.||:.    ..|.:||..|....|.|.: .|.|.|||.|
pombe   509 -----------------LEKAGGVFPFSGTD----ERCLVCLSNFELNDECRRLKQCNHFFHREC 552

Human   299 VDPWL-HQHRTCPLC 312
            :|.|| ....:||||
pombe   553 IDQWLTSSQNSCPLC 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	23/114 (20%)
RNF43	XP_011523257.1	zf-RING_2	270..312	CDD:290367	17/43 (40%)
SPBP4H10.07	NP_596181.1	PHA03328	77..>156	CDD:223046
		zf-rbx1	<522..568	CDD:289448	19/50 (38%)
		RING	525..570	CDD:238093	19/43 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910