DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF43 and Rnf43

DIOPT Version :9

Sequence 1:	XP_011523257.1	Gene:	RNF43 / 54894	HGNCID:	18505	Length:	869	Species:	Homo sapiens
Sequence 2:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus

Alignment Length:	778	Identity:	631/778 - (81%)
Similarity:	672/778 - (86%)	Gaps:	7/778 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTL 65
            ||||||||||.||||||||||.||||.||.||||||||||||||||:||||||||||||||||||
Mouse     1 MSGGHQLQLAVLWPWLLMATLHAGFGHTGRVLAAAVESERSAEQKAVIRVIPLKMDPTGKLNLTL 65

Human    66 EGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAG 130
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 EGVFAGVAEVTPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAG 130

Human   131 ERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWP 195
            ||||:||||||||||:||||||||||||.|||||||:||.|||||||||:||:|.||||||||..
Mouse   131 ERGANAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSDAAKLMEFVYKNRKAYVWIELKEPPAGA 195

Human   196 DYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWP 260
            :||||||:|||||:|||||||||||||||.||||||||||||.||||||||||||.||:||.|||
Mouse   196 NYDVWILLTVVGTVFVIILASVLRIRCRPHHSRPDPLQQRTARAISQLATRRYQAGCRRARAEWP 260

Human   261 DSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQS 325
            ||||||||.|||||||||||||||||||||||||||.||||||:||||||||||||.|||||||:
Mouse   261 DSGSSCSSTPVCAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEGDSFSQA 325

Human   326 LGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRF 390
            ...|.||||||||||||||||||||||||:||||||||::|||.|||.||||||||.||.||.|.
Mouse   326 PAASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPFLPSQEPSMGSRHQRL 390

Human   391 PRAAHPRAPGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERS 455
            ||.:|.|||.|||.||.:.|||||||||:.|:.||||||||||.||||||.:|||||||||||||
Mouse   391 PRTSHLRAPEEQQHLAVSPHPYAQGWGLNRLRCTSQHPAACPVALRRARPHESSGSGESYCTERS 455

Human   456 GYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRV 520
            |||||||||||||||||||||||||||||:||||:|||||||.|||||||||||||||:||.|..
Mouse   456 GYLADGPASDSSSGPCHGSSSDSVVNCTDVSLQGIHGSSSTFRSSLSSDFDPLVYCSPEGDLQGK 520

Human   521 DMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRT 585
            .:||||||||||||||||.||||||||:|||||||||||::|||||||||||||:|||.|....|
Mouse   521 GIQPSVTSRPRSLDSVVPRGETQVSSHIHYHRHRHHHYKRQFQWHGRKPGPETGIPQSMPAASHT 585

Human   586 QPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPS----TSSLFNLQKSS 646
              |.||..||||:...|..| |..|.|||.||||.|||||..:|||..||    .|.|.||||||
Mouse   586 --QLEPSLPDQQLITPNPTA-SSMLPNPQRPRALTEPAPGLAEASSPSPSPKPNPSGLLNLQKSS 647

Human   647 LSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLL 711
            |:.|||.||||||||||.|.|.|.|.|||.||.:||||:|.:||||.||.|||:..|||.|:|||
Mouse   648 LTVRHPHRKRRGGPSEPLPTSLPPDLTVHTACPVFPHYSPRLAYPWPPEVHPLMFRPPGPDRRLL 712

Human   712 PETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSE 774
            .|.||||||:||||||.|.|.|||.|..||||.|:|:.|:.|||.|||.|||||.||||...|
Mouse   713 HEVPGPCYSSSQPVWLYLNPCQPLGPCLPGEGHSKWTFDSPEGRRCPYSHCQVLPAQPGSEEE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	91/98 (93%)
RNF43	XP_011523257.1	zf-RING_2	270..312	CDD:290367	39/41 (95%)
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	39/41 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407		29/42 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478		18/18 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671		107/157 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970744
Domainoid	1	1.000	739	1.000	Domainoid score	I3389
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37742
Inparanoid	1	1.050	1317	1.000	Inparanoid score	I3756
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38388
OrthoDB	1	1.010	-	-		D109650at7742
OrthoFinder	1	1.000	-	-		FOG0013512
OrthoInspector	1	1.000	-	-		oto127920
orthoMCL	1	0.900	-	-		OOG6_118517
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13356
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.400