DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF43 and plr-1

DIOPT Version :9

Sequence 1:	XP_011523257.1	Gene:	RNF43 / 54894	HGNCID:	18505	Length:	869	Species:	Homo sapiens
Sequence 2:	NP_499473.2	Gene:	plr-1 / 176575	WormBaseID:	WBGene00023404	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	116/515 - (22%)
Similarity:	183/515 - (35%)	Gaps:	159/515 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    36 VESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDD--DN 98
            :..:|:.::|.|                .|.|.|:.|.......|.::|......|:|...  ||
Worm    49 INEDRTQDEKTI----------------KLSGTFSPVGSNYETGGDIVQVSSFRACDARRKGLDN 97

Human    99 LEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL---GLTWP 160
            .....:.:|..:...:....|::|.::||.|.:.||.|:   |....:..|:..:|:   |...|
Worm    98 TVFEHVPVVFYDDVEKFLTGCVALDNQARFAEKSGAMAL---IVGPASRVERTTRPMMIGGSKIP 159

Human   161 VVLIWGNDAEKL-----------------MEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGT 208
            |:::.....|:|                 :.|:.:.....:::::..|..       :.:|::|.
Worm   160 VIVLDDEQTERLRSELRSASERGAVTKLRISFIDEKPTKVLKLQVFRPTV-------LNITLLGL 217

Human   209 IFVII----LASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQ-----------------ASC 252
            :.::|    |..|::|||:|...|...|:.....|::::..|.:|                 |..
Worm   218 LIILIVFVSLLVVVKIRCQPTMHRELWLRALARTALTKMEIRSFQKEKNVEAGQKKKTSSTFARL 282

Human   253 RQARGEWP---------------DSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPW 302
            :|.|....               ...||.|:...|.|||||:.||.||||:.|.||||..|||||
Worm   283 KQHRSSSSRHSSYLAVFGSLTSVAQSSSHSAQERCVICLEEYEEGTELRVLFCGHEFHPKCVDPW 347

Human   303 LHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAA----YLLGPSR 363
            |...|.||||.|::                                .:.|.|..    .|.|.|.
Worm   348 LLSKRRCPLCQFDV--------------------------------VYKHYPKVDSPEKLSGRSD 380

Human   364 SAVARPPRPGPF--LPSQEPGMGPR--------HHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGL 418
            ...:..||..|.  |||.......|        ||..|.:..|         :..|.|
Worm   381 DTTSLLPRTSPSEDLPSAPSSRSTRLTRPYRTTHHLIPSSTRP---------SSHQRP------- 429

Human   419 SHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDS 478
             .||.|:....:||   ||.:.  .|.:...:.....||     :||.||.  |...|.|
Worm   430 -SLQPTAPRTRSCP---RRRQL--RSRNQIDFSIRIGGY-----SSDVSSS--HAEQSRS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	22/120 (18%)
RNF43	XP_011523257.1	zf-RING_2	270..312	CDD:290367	26/41 (63%)
plr-1	NP_499473.2	zf-rbx1	305..358	CDD:289448	30/52 (58%)
plr-1	NP_499473.2	zf-RING_2	317..357	CDD:290367	26/39 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I6861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15609
orthoMCL	1	0.900	-	-		OOG6_118517
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780