DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF43 and rnf167

DIOPT Version :9

Sequence 1:	XP_011523257.1	Gene:	RNF43 / 54894	HGNCID:	18505	Length:	869	Species:	Homo sapiens
Sequence 2:	XP_005165694.2	Gene:	rnf167 / 101055497	ZFINID:	ZDB-GENE-110126-2	Length:	401	Species:	Danio rerio

Alignment Length:	324	Identity:	79/324 - (24%)
Similarity:	128/324 - (39%)	Gaps:	76/324 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    80 GKLMQSHPLYLCNASD---------DDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGAS 135
            |.|:::.|...|...|         |.|....:|.:::        |...:...|...|.:.|.|
Zfish    59 GVLIEARPQNACTPIDPPPASPTPADPNSTTKYIVLIR--------RYDCNFDVKVYHAQQAGYS 115

Human   136 AVLFDIT----------EDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKE 190
            |.:....          .:...||::..|...|       ...|.:::..:...:.|:|  .||.
Zfish   116 AAIVHNMYSNSLLNMGYSNETIAEEISIPSVFT-------SFFASQMLHKIIPEKGAYV--VLKP 171

Human   191 PPAWPDYDVWILMTVVGTIFVIILASVLRIRC-----RPRHSRPDPLQQRTAWAISQLATRRYQA 250
            ..::|.....|..|.|..:.:|::..::.:||     |.|.:|....|      :.::...::.
Zfish   172 EFSFPLSYYLIPFTGVVCMIIIVMVIIMIVRCVQHRKRLRKNRLSKEQ------LKKIPIHKFN- 229

Human   251 SCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQ-HRTCPLCMF 314
                 :|:         |..||||||:|:.||.:|||:.|.|.:|..||||||.| .:|||:|..
Zfish   230 -----KGD---------SYDVCAICLDEYEEGDKLRVLPCSHAYHSRCVDPWLTQTKKTCPVCKQ 280

Human   315 NIT-------EGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLGPS-RSAVARPP 370
            .:|       |.....:..||..:.:|..|...|...:||.     ||:....|| .|.||..|
Zfish   281 RVTRPNPEYSESSDSDEEAGPHDAEEEDERTPLLRPSNPGS-----PASSSPPPSYSSTVASEP 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	19/117 (16%)
RNF43	XP_011523257.1	zf-RING_2	270..312	CDD:290367	25/42 (60%)
rnf167	XP_005165694.2	PA_C_RZF_like	14..177	CDD:239038	23/134 (17%)
		RING-H2_RNF167	235..280	CDD:319711	26/44 (59%)
		RING-H2 finger (C3H2C3-type)	237..278	CDD:319711	24/40 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920