Protein Alignment NSUN2 and NCL1

DIOPT Version :10

• Sequence 1: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_009529.1
• Gene: NCL1 / 852257
• SGDID: S000000120
• Length: 684
• Species: Saccharomyces cerevisiae
• Alignment Length: 757
• Identity: 266/757 - (35%)
• Similarity: 398/757 - (52%)
• Gaps: 130/757 - (17%)

Human    27 GKRGEAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEIL 91
            |.|.::..:..:.|:||||:.:|.||:.|.:.||.:|.:|....:.|||.|.||||.:.||.|:|
Yeast    16 GARDDSRAQKNWSELVKENEKWEKYYKTLALFPEDQWEEFKKTCQAPLPLTFRITGSRKHAGEVL 80

Human    92 HCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESG 156
            :..|.::...|.::|.:|:|::.|..|.|||:.|||..::.:.::||:....|..:|||.|...|
Yeast    81 NLFKERHLPNLTNVEFEGEKIKAPVELPWYPDHLAWQLDVPKTVIRKNEQFAKTQRFLVVENAVG 145

Human   157 NISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRC 221
            |||||||||||||::|.|:|||.:|||||||||||.||||.||.|.:.  |.|||:|||.|.:|.
Yeast   146 NISRQEAVSMIPPIVLEVKPHHTVLDMCAAPGSKTAQLIEALHKDTDE--PSGFVVANDADARRS 208

Human   222 YLLVHQAKRLSSPCIMVVNHDASSIPRLQI--DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVW 284
            ::||||.|||:|..:|||||||...||:::  :.:.:.::|.:||||||||||||||||||::||
Yeast   209 HMLVHQLKRLNSANLMVVNHDAQFFPRIRLHGNSNNKNDVLKFDRILCDVPCSGDGTMRKNVNVW 273

Human   285 KKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVS 349
            |.|.|...|.||.:||.|..||...|...||:|||||||||||:|||:|..|.|....:.|.:..
Yeast   274 KDWNTQAGLGLHAVQLNILNRGLHLLKNNGRLVYSTCSLNPIENEAVVAEALRKWGDKIRLVNCD 338

Human   350 NELPGLKWMPGITQWKV-------MTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLE 407
            ::||||....|:::|.|       .||..:...|              :.|.|.: |:....:|:
Yeast   339 DKLPGLIRSKGVSKWPVYDRNLTEKTKGDEGTLD--------------SFFSPSE-EEASKFNLQ 388

Human   408 RCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLE 472
            .|:|:.||.|||||||:.|..|                   ..:||:.:         |:....|
Yeast   389 NCMRVYPHQQNTGGFFITVFEK-------------------VEDSTEAA---------TEKLSSE 425

Human   473 SPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFK----------EDPFVFIPEDD 527
            :|:               ||:.|         |.:||:|:...:          |:||||:   |
Yeast   426 TPA---------------LESEG---------PQTKKIKVEEVQKKERLPRDANEEPFVFV---D 463

Human   528 PLFPPIE---KFYALDPSFPRMNLLTRTTEGK-KRQLYMVSKELRNVLLNNSEKMKVINTGIKVW 588
            |....::   .||.:|..|.|...|.|...|: .|.:|.|...|::|:..|.:::|:|.:|:|::
Yeast   464 PQHEALKVCWDFYGIDNIFDRNTCLVRNATGEPTRVVYTVCPALKDVIQANDDRLKIIYSGVKLF 528

Human   589 CRNNSGEEFDCAFRLAQEGIYTLYPFINS-RIITVSMEDVKILLTQENPFF-----RKLSSETYS 647
            ....|  :.:|::|:..|.:..:...:.| ||:..::|.:|.||.:..|.|     :.:.::...
Yeast   529 VSQRS--DIECSWRIQSESLPIMKHHMKSNRIVEANLEMLKHLLIESFPNFDDIRSKNIDNDFVE 591

Human   648 QAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNERLHYL--RMMGLEVLG-- 708
            :...|:.|...:....:....:.|..|:    |:|...|...|.| |..|.|  |:.|::...
Yeast   592 KMTKLSSGCAFIDVSRNDPAKENLFLPV----WKGNKCINLMVCK-EDTHELLYRIFGIDANAKA 651

Human   709 -------EKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNS 743
                   ||:||    |.||.|.|       |.|.....|::
Yeast   652 TPSAEEKEKEKE----TTESPAET-------TTGTSTEAPSA 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		2/8 (25%)
		RsmB	<59..431	CDD:439914	179/380 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		5/44 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767		7/25 (28%)
NCL1	NP_009529.1	RsmB	<44..412	CDD:439914	180/403 (45%)