Protein Alignment NSUN2 and nsun2

DIOPT Version :10

• Sequence 1: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_001015962.1
• Gene: nsun2 / 548716
• XenbaseID: XB-GENE-962623
• Length: 798
• Species: Xenopus tropicalis
• Alignment Length: 783
• Identity: 558/783 - (71%)
• Similarity: 624/783 - (79%)
• Gaps: 50/783 - (6%)

Human     1 MGRRSRGRRLQQQQRPEDAEDGAEGGGK---RGEAGWEGGYPEIVKENKLFEHYYQELKIVPEGE 62
            ||||:| |..|:.||..:....||...:   |.:|.||.|||||:|||||||||||||||||:||
 Frog     1 MGRRNR-RNRQRHQRSTEQRSPAEEEQRRKAREQAAWECGYPEIIKENKLFEHYYQELKIVPDGE 64

Human    63 WGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAW 127
            |.:||.:||||||||:|||||||||||||||||.||||||:|:||||||:|.|||||||||||||
 Frog    65 WDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKELQDIEVDGQKIEAPQPLSWYPEELAW 129

Human   128 HTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTT 192
            ||||||||:||||.|||||||||:||||||||||||||||||:||.|:||||||||||||||||.
 Frog   130 HTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTA 194

Human   193 QLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDVDGRK 257
            |:|||||||||||||||||||||||||||||||||||||:|||||||||||||||||.::.:|.:
 Frog   195 QIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSR 259

Human   258 EILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCS 322
            |:|:|||||||||||||||:||||||||||||||||||||||:||||||.|||||||||||||||
 Frog   260 EVLYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCS 324

Human   323 LNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQ 387
            |||:||||||||||:||||:||||||::|:|||||||||||||||||:|.|:..|:.:|.|||||
 Frog   325 LNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQ 389

Human   388 IRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGK------- 445
            ||||||||||.|||::|:|.||:|||||||||||||||||:||:.|||||||||||.:
 Frog   390 IRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNKRQPKLQRRPPVSACD 454

Human   446 ----------SAETRESTQLS--PADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKK 498
                      .|.|..|..::  ||..||...|.|...:|.|                    ||.
 Frog   455 ASIAVAPELVKAVTENSAGMADEPAVDTENGETKPCTNQSDS--------------------SKT 499

Human   499 DGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMV 563
            |.||.|||||||||||||||||||:.||||:|.||:.|||||||||:.||||||.||||||||||
 Frog   500 DIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMV 564

Human   564 SKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVK 628
            |||||||||:||||||||||||||.||||.||::.||:|||||||||||||||:||:|||:||:|
 Frog   565 SKELRNVLLHNSEKMKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINARIVTVSIEDIK 629

Human   629 ILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKN 693
            :||||||||..|.|.||..||.:...||||||||||...|:.|||||||||||||.|||:|||||
 Frog   630 VLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETLQCPIVLCGWRGKTSIRSFVPKN 694

Human   694 ERLHYLRMMGLEVLGEK-----KK--EGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANS 751
            ||||||||||:||..||     ||  ||.....|........|....|.:......|.|.|:...
 Frog   695 ERLHYLRMMGVEVFKEKAEVLEKKPVEGKACDEEHIDEKMDIDGAKEESKELSGNESGDDEDPKE 759

Human   752 PDV 754
            .||
 Frog   760 EDV 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		14/37 (38%)
		RsmB	<59..431	CDD:439914	317/371 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		19/63 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767		8/36 (22%)
nsun2	NP_001015962.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		11/29 (38%)
		RsmB	<18..433	CDD:439914	344/414 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..499		9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	723..798		8/40 (20%)