Protein Alignment NSUN2 and Nsun2

DIOPT Version :10

• Sequence 1: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_652007.1
• Gene: Nsun2 / 45064
• FlyBaseID: FBgn0026079
• Length: 746
• Species: Drosophila melanogaster
• Alignment Length: 789
• Identity: 331/789 - (41%)
• Similarity: 453/789 - (57%)
• Gaps: 81/789 - (10%)

Human     1 MGRRSRGRRLQQQQRPEDAEDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQELKI-VPEGEWG 64
            |||..:......::|.:     .|.|.||.:...: .|.||.::|..|..|||..|| ..:.||.
  Fly     1 MGRNQKQNFFAARKRQK-----RENGPKRTDRQAQ-PYEEIKRDNAFFIKYYQLQKICATDEEWT 59

Human    65 QFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKE----LEDLEVDG-QKVEVPQPLSWYPEE 124
            ||:.::|:.||.|.|:||:|..||.:|..::.:.|.|    :.:|.... :.||.|..|.|||..
  Fly    60 QFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNG 124

Human   125 LAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGS 189
            ||:..:|:||.:|:|..|.:.|.||:.||.:|.||||||||||||::|:|||..|:|||||||||
  Fly   125 LAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGS 189

Human   190 KTTQLIEMLHADMNVP----FPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRL- 249
            ||.||||.|||   .|    .|.|||:||||||.|||:||||||||:|||::|.|||:|..|.|
  Fly   190 KTAQLIEALHA---APEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLV 251

Human   250 QIDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGG 314
            ....||.|.||.:|:||||||||||||:|||.|:|.||....:..|||:|.||..||||.|..||
  Fly   252 TTKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGG 316

Human   315 RMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKD-GQWFTDWD 378
            |:|||||||||||:|||:..:::.::|||||.|..:.:||||:.||:|.||:.||: .|.||.::
  Fly   317 RLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFE 381

Human   379 AVPHSRHTQIRPTMFP-PKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKL 442
            .||.|.||.|||.||| |.|  ::..:.||:|||:|||.|::||||||||.|:..:.:.|.....
  Fly   382 EVPESLHTIIRPGMFPLPAD--EMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDVVE 444

Human   443 QGKSAETRESTQLSPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPS 507
            ..|..||.:.....|....:|||.:                              :..|...|..
  Fly   445 LVKLNETAKQPAAEPQVDADGKPIE------------------------------EKSVPWGPQR 479

Human   508 KKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLL 572
            ||.:|.|:||||:||..|:||.:..|::||.||.|..:..||||....||:.:|..|:.:|:::|
  Fly   480 KKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLVL 544

Human   573 NNSEKMKVINTGIK--VWCRNNSGEEFDCAFRLAQEGIYTLYPFIN-SRIITVSMEDVKILLT-- 632
            ||...:|:||||:|  |.|.|.....   .|||||||:.|...|:. ||.|.|..||:.::|.
  Fly   545 NNENNIKIINTGVKTFVRCENRHTVH---PFRLAQEGLQTSNAFMGASRRIQVEREDLVMMLNCT 606

Human   633 --QENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNER 695
              .:.|...:|..||..:.|:|..||.:|||...       :..:...||||.:|:|.:|.|:|.
  Fly   607 DPTQPPSTHELKKETQERCKELGVGSCILKYVDQ-------RFTLYTVGWRGTSSLRAYVQKDET 664

Human   696 LHYLRMMGLEVLGEKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANSP-------D 753
            :|.||::|.::   .|.|.....:...|:....|.:|.:...|...:|.|.:...|.       |
  Fly   665 IHILRLLGADL---SKFETNKYEDARVAAAAAADAEVGKSAEAEADSSGDGDATESTFSGSGAID 726

Human   754 VTAGCDPAG 762
            ||...:..|
  Fly   727 VTVAAETTG 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		8/34 (24%)
		RsmB	<59..431	CDD:439914	210/383 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		8/44 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767		11/51 (22%)
Nsun2	NP_652007.1	RsmB	<55..433	CDD:439914	210/382 (55%)