Protein Alignment NSUN2 and trm401

DIOPT Version :10

• Sequence 1: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_594695.3
• Gene: trm401 / 2542264
• PomBaseID: SPAC17D4.04
• Length: 688
• Species: Schizosaccharomyces pombe
• Alignment Length: 732
• Identity: 266/732 - (36%)
• Similarity: 395/732 - (53%)
• Gaps: 118/732 - (16%)

Human    28 KRGE-AGWEGGYPEIVKENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEIL 91
            |:|| ..|:    .|.::|:.||.||:..|:|.|.::......|.|.||.|.|||....||.::.
pombe    14 KKGEFVNWD----LIERKNENFEKYYRLQKLVTEDDFILLKQKLTEQLPTTFRITASIPHATQVR 74

Human    92 HCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESG 156
            ......|:..:|:...:..|:.:|..|.|||:.:|:..::|::::||||||:...:|||.|||:|
pombe    75 DYFIEHYYPLIENARTEDAKIPLPVSLPWYPDGMAFMLDISKEVIRKSPHLKALQEFLVLETEAG 139

Human   157 NISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLH-----ADMNVPFPEGFVIANDV 216
            :|:|||:|||:|||||||..|||:|||||||||||.||:|.||     .|:....|.|.|||||.
pombe   140 DINRQESVSMVPPLLLNVESHHKVLDMCAAPGSKTAQLLEALHKPTKKEDITTLLPSGIVIANDS 204

Human   217 DNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDVDGRKEILFYDRILCDVPCSGDGTMRKNI 281
            ||||.::||||.|||:||.:::||||||.:|...:.....|:.|.:||||.|||||||||.||||
pombe   205 DNKRAHMLVHQIKRLNSPNVLIVNHDASFLPNFHLSSPDGKKFLKFDRILADVPCSGDGTFRKNI 269

Human   282 DVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELA 346
            .:|.:|:...:|.||..|::|..||.:.|.:|||:|||||||||||:|||::::|..:.|::.|.
pombe   270 ALWNEWSLKTALGLHATQIKILMRGLQLLEKGGRLVYSTCSLNPIENEAVVSAVLNATRGSVRLV 334

Human   347 DVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFP-PKDPEKLQAMHLERCL 410
            |||:|||.||...|:..|.|...|...:..:|.:|...:.::.||::| ||  ::|..::::.||
pombe   335 DVSSELPQLKRSQGVDNWVVCDSDLNIYPSFDTLPKELYEKMPPTLWPLPK--KELAELNIQNCL 397

Human   411 RILPHHQNTGGFFVAVLVK--------KSSMPWNK---RQPKLQGKSA--ETRESTQLSPAD--L 460
            ||.||.|||||||||||.|        |:::..||   |:.||..:.|  :.::.||.:.:|  |
pombe   398 RIYPHFQNTGGFFVAVLEKYENLTSSMKTAVDDNKVFLREQKLPSEQASKKRKQDTQETSSDSKL 462

Human   461 TEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKE-DPFVFIP 524
            .|.||..                        :|.|::                 |.| ||||:|.
pombe   463 AEVKPKG------------------------KNGGNR-----------------FHELDPFVYIK 486

Human   525 EDDPLFPPIEKFYALDPSFPRMN-LLTRTTEGKKRQLYMVSKEL-RNVLLNNSEKMKVINTGIKV 587
            |||.....|.|.:.:|.:..:.| ...|...|...:...:|.:| |||:.||..::|.::.|:|:
pombe   487 EDDQALEKIYKKFGIDEAIIKKNQFFVRNVNGVPTKAIYISNDLFRNVIENNRNRVKFVHGGLKI 551

Human   588 WCRNNSG--------EEFDCAFRLAQEGIYTLYPFI-NSRIITVSMEDVKILLTQ---------E 634
            :.|.:.|        :...|.||:..:|......|| .|.:...::.|:.|||..         |
pombe   552 FVRQDFGSLSREIAEKNGTCVFRVQSDGANLASHFIAESCLFHTTLSDLFILLDHEAVTIDDFPE 616

Human   635 NPFFRKLSSETYSQAK--------DLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVP 691
            :..|||    .|:...        ||||...|:|.:        :..|:    |:........:.
pombe   617 DSLFRK----EYNHLDLGSTLLHVDLAKEESVIKKQ--------VYIPL----WKSVRICNVLLS 665

Human   692 KNERLHYLRMMGLEVLG 708
            .:|:    |.:.|::.|
pombe   666 NSEK----RTLKLQIEG 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		4/8 (50%)
		RsmB	<59..431	CDD:439914	182/385 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		13/51 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767
trm401	NP_594695.3	RsmB	<88..416	CDD:439914	168/329 (51%)