Protein Alignment NSUN2 and trm402

DIOPT Version :10

• Sequence 1: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_593189.2
• Gene: trm402 / 2541917
• PomBaseID: SPAC23C4.17
• Length: 685
• Species: Schizosaccharomyces pombe
• Alignment Length: 727
• Identity: 272/727 - (37%)
• Similarity: 396/727 - (54%)
• Gaps: 90/727 - (12%)

Human    27 GKRGEAGWEG--GY---PEIVKENKLFEHYYQELKIV---PEGEWGQFMDALREPLPATLRITGY 83
            |||.:...:|  .|   .|||.|||.||.||::..:.   |..|:..||:.:|:|||.|.||.||
pombe     2 GKRNKKVTQGKRAYNDKSEIVLENKQFEGYYKKQNLFRGKPNDEFDSFMEYMRKPLPTTFRICGY 66

Human    84 KSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPHLEKFHQF 148
            :.||.|:.:..:..|...|:::..:||.:..|..|.|||:.||:..:..:.::||||.|::..:|
pombe    67 RHHAFELKNHFEKYYVPSLKNVVHEGQTIPPPTVLPWYPDGLAYIVDAQKDVIRKSPPLKRLQRF 131

Human   149 LVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEML----------HADMN 203
            ||||.|:|||:|||||||:|||.|:|.|||.||||||||||||.||||.:          |...|
pombe   132 LVSENEAGNINRQEAVSMLPPLFLDVEPHHVILDMCAAPGSKTAQLIEAVYKKANIKDAAHDSKN 196

Human   204 VPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQI---------DVDGRKEI 259
            :...||.|||||.|.||..:||||..||:||.|:|||||||::|.:.:         :|...|:|
pombe   197 LKSVEGLVIANDADPKRAQMLVHQINRLNSPNILVVNHDASTMPNIYVKGSSPSDGLNVIEEKKI 261

Human   260 LFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLN 324
            |.:||||.|||||||||.|||:.:|::|:..::..||.|||||..||.:.|..||.:||||||:|
pombe   262 LKFDRILADVPCSGDGTFRKNLSLWREWSANSAFSLHPLQLRILIRGLQLLKVGGCLVYSTCSIN 326

Human   325 PIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIR 389
            |||:|||:.:.|:.:.||:.|.|||.:||.||..||:..|||:...   ..::.:...:.:.:|.
pombe   327 PIENEAVVTAALKATGGAVSLVDVSKKLPLLKRDPGLLSWKVLDDS---LNEFQSPAENTNDKIE 388

Human   390 PT--MFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKR--QPKLQGKSAETR 450
            .|  |:|..: |::..:|:|||.|:.||.|||||||||||.|..  |.|.|  .||....|.|.
pombe   389 LTESMWPLPE-EEMSKLHIERCARLYPHMQNTGGFFVAVLQKTD--PINSRSFDPKKYTASMEI- 449

Human   451 ESTQLSPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGF 515
                |.|    |.|.....|         |..|.:::|  |..:|:..                |
pombe   450 ----LPP----ENKRQRTEK---------GVDEASNST--LTKSGNSY----------------F 479

Human   516 KEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEG-KKRQLYMVSKELRNVLLNNSEKMK 579
            .|:|||:|..||.....|..||.:||||||.....|...| ..|.:|......:.::..|:.::|
pombe   480 DEEPFVYINPDDTSIKTIVDFYGIDPSFPRDQFFVRNQSGIPVRSIYFACSLFKEIIEANTNRVK 544

Human   580 VINTGIKVWCRNNSGE---EFD-------CAFRLAQEGIYTLYPFINSR-IITVSMEDVKILLTQ 633
            .::.|::.:.:....:   :|.       |.||:...|:..:.||:|.: .....::|:|||:..
pombe   545 FVHGGVRFFVKQEISQLLKDFSLKANKDICNFRIHSNGVNIISPFLNEKHFYDAGLKDLKILVKN 609

Human   634 ENPFFRKLSSETYSQAKDLAK---GSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNER 695
            |.|...:. ||:....|:..|   |..:|:.:..:.:...:...|:...||...|....:.:.|:
pombe   610 EYPHVEQF-SESGMLKKEFEKMPLGCNILRVDAQTKDGALMDMLILQPIWRSPTSCNLMLARKEK 673

Human   696 LHY-LRMMGLEV 706
            .:. |.:.|::|
pombe   674 QNLSLELFGMDV 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		3/8 (38%)
		RsmB	<59..431	CDD:439914	188/392 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		11/46 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767
trm402	NP_593189.2	RsmB	<99..431	CDD:439914	167/335 (50%)