Protein Alignment NSUN2 and nsun-2

DIOPT Version :10

• Sequence 1: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_490830.3
• Gene: nsun-2 / 171697
• WormBaseID: WBGene00021686
• Length: 684
• Species: Caenorhabditis elegans
• Alignment Length: 762
• Identity: 264/762 - (34%)
• Similarity: 397/762 - (52%)
• Gaps: 109/762 - (14%)

Human     3 RRSRGRRLQQQQRPEDAEDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWGQFM 67
            |:.:.:....:.|.....|..:..|.:       ||..:.|||:.:..||:|..:.|..::.:|.
 Worm     7 RKFKSKNKGHEPRENVWRDDRDAPGNQ-------GYRMVEKENEKYWQYYKEQNVFPLEQFDEFR 64

Human    68 DALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLS 132
            .||:..||.:.|..|.....::::|.::|::|.::  :|.....|.||:.|.||.|  |:.|.:|
 Worm    65 AALQRDLPVSFRFQGCHKDREQLIHEMENRFFGKI--MEAGDTAVCVPKSLPWYKE--AYQTPMS 125

Human   133 RKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEM 197
            |..:|..|.|.:.|.|||:|.|.||:||||||||||||||.....|.:||:|||||||||||:||
 Worm   126 RTAVRSHPILAQLHNFLVTEAELGNLSRQEAVSMIPPLLLAPTSEHFVLDLCAAPGSKTTQLLEM 190

Human   198 LHADMNVPFPEGFVIANDVDNKRCYLLVHQA-KRLSSPCIMVVNHDASSIPRLQIDVDGRKEILF 261
            :|.  |...|:|.|||||||.||||:|:|.. ||..:....|...||:..|.:. |.||  .::.
 Worm   191 IHE--NEENPKGMVIANDVDMKRCYMLIHHTLKRFRTAACAVTCEDAARFPHIS-DSDG--GLIQ 250

Human   262 YDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPI 326
            :||:|.||.||||||:|||.::|||||..:.|.||.:|:.||.:||:||..||||||||||:|||
 Worm   251 FDRVLADVICSGDGTLRKNPEIWKKWTPQDGLGLHRMQIAIARKGAQQLKVGGRMVYSTCSMNPI 315

Human   327 EDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQ-IRP 390
            |||||:|.||..|:|:|:|.|.|:.||.||...|:.||||..:|.:.:...:.:...:..: |..
 Worm   316 EDEAVVAQLLRDSKGSLKLVDTSSLLPELKRETGVVQWKVFDRDMKLYKSLEDISEEKMKKVIVS 380

Human   391 TMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQL 455
            ::|||.:.| .:.|:|...:||.||.|:|||||||::.|.|...:
 Worm   381 SLFPPTEQE-AKEMNLHFTMRITPHAQDTGGFFVALIEKVSETSF-------------------- 424

Human   456 SPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPF 520
                       |||....|::                               ||.|:  ||::||
 Worm   425 -----------DPSAANGPAW-------------------------------KKKKM--FKDEPF 445

Human   521 VFIPEDDPLFPPIEKFYALDPSFPRMNLLTR---TTEGKKRQLYMVSKELRNVLLNNSEKMKVIN 582
            .|:..||..:..|...|.:|.||...||.:|   :.:...|||:..:..::|.:..|..|:.:.|
 Worm   446 TFLKLDDERWNDIRNHYGVDESFLYQNLFSRRLESNDANSRQLFYANDAVKNFVKENMSKVSIQN 510

Human   583 TGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKILLTQENPFFRKLSSETYS 647
            .|:|::.| ..|:..:..|||:||||..|:.|:..:.:.:..||:..:|..:.........|...
 Worm   511 AGMKMFSR-TEGKVENTRFRLSQEGIRYLFKFMQKQKVKIGTEDMLFMLKSDENLVPLEKLECKG 574

Human   648 QAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE------V 706
            ..:....|::|:..:.|.        |:  |.|.|..:|..::.|.||||.|||||::      :
 Worm   575 DVRKQQNGTVVVYCDDDE--------PV--CTWVGYHTIAPYISKEERLHLLRMMGVDCAEIELL 629

Human   707 LGEKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANSPD 753
            :..|:||......|:|.:..:      |..:|.||:|...:...|.:
 Worm   630 MKSKRKEKAAQDREAAWARKE------EAAKAAEPSSSSTDAPESAE 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		4/32 (13%)
		RsmB	<59..431	CDD:439914	176/373 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		4/44 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767		8/35 (23%)
nsun-2	NP_490830.3	RsmB	<46..420	CDD:439914	179/383 (47%)