DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rlim and mura

DIOPT Version :9

Sequence 1:	NP_001016091.1	Gene:	rlim / 548845	XenbaseID:	XB-GENE-492020	Length:	639	Species:	Xenopus tropicalis
Sequence 2:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster

Alignment Length:	661	Identity:	142/661 - (21%)
Similarity:	214/661 - (32%)	Gaps:	209/661 - (31%)

- Green bases have known domain annotations that are detailed below.

Frog    85 GDPVSASGDPAEDSSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINV 149
            |:.....|....|.:.|.|    .|.:|..|.:...|...|.|.........|:|         .
  Fly   548 GNSEQNGGPDHRDRAEGSS----YNFMRNGGGSGGGGYGRNGSHYQHMAYGNNNG---------A 599

Frog   150 NRTSGNPSMPSLEQSSEMPGAEDMEVSSQGENENEPEPVAPRVAQAEVTEEAPVQRGQRRARSRS 214
            :.::|.|.:     ..|:|....:..||...| |.|         ..:..::| .|.:||...|.
  Fly   600 STSTGGPGL-----MGELPSGSGLSGSSLSLN-NGP---------GGLNSDSP-SRKRRRISGRP 648

Frog   215 PDQRRTRARTDRSRSPLHQAVEPPIRRAQHSSSQTVDASSTEEAEGSSRTRHHVSSQMQNSSSSN 279
            |:..:.:.|...:..   |...||:||.:   .:.|..|:.::.:......||...|.|...|:.
  Fly   649 PNGPQPQHRCPMAHM---QQGSPPLRRPR---LRDVATSTQQQQQQYGHQVHHPQQQQQQPPSNY 707

Frog   280 ETEGSSRTRQHITARQQA-----------LGTEGQSQSQTQTQSQSQTQTQSQTQSQSTVHLSNP 333
            ......:.:.|...:||.           ||:.|.| |...|.|.|......|.|:
  Fly   708 HPMHHHQPQPHYVPQQQVPPPHVQRSPWDLGSSGGS-SGGATSSSSVGPILQQVQA--------- 762

Frog   334 ESRSSSQPPQTDSSSNAETTGTGQRPP---TIVLDLQVRRV------RP---------------- 373
                   |||..|...|  .|..|.||   ::::||.:.:|      ||
  Fly   763 -------PPQPPSHQQA--VGYPQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQ 818

Frog   374 ---------GDYRQ-------------------------RDSIANRTRSRSQTPNNTVTYESERG 404
                     |.|.|                         :..|:..|.:..|...:.|...:...
  Fly   819 ARLAPCHLHGVYTQPFPAAPPPGLAAPPLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANL 883

Frog   405 GFRRTFSRSERAGV--------RTYVSTIRIPIRRILNTGLSETTSVAIQTMLR----------- 450
            |      ..|..|.        ..:....::| ..|..|.||...:.|....|.
  Fly   884 G------PIEAPGAHGHPHAHPHAHPHAHQLP-PGIHITPLSGAAAAAATHHLHSTAAAAAAVAA 941

Frog   451 --QIMTGFGELSYFMYNDNDTDPNNPTP-----------VSPPAAVPGEAQNLVSPEPP------ 496
              ||.|  .:...|..:.....|:...|           |.||       |:|.:.:.|
  Fly   942 GAQITT--AQQILFSSDRRTFPPHRRIPRFWTANHGHRHVLPP-------QSLAAHQAPVQIQAT 997

Frog   497 APIVEP--------PEPVAPVESEEGSNVSTSSARREGRNSRGGVTFEESGSLPFLSLAQFFLLN 553
            :.|:.|        ..|::|....:.|:               |.|.|.......||||:..
  Fly   998 SGIINPGFLLNFLAMFPLSPYNQHDLSS---------------GDTNETENYEALLSLAERL--- 1044

Frog   554 EDDDDQPRGLTKEQIDNLSTRNFG---ENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 615
              .:.:|||||:.:||.|.:..|.   .|....:|.||:.::.....||.||||||:|..|:|:|
  Fly  1045 --GEAKPRGLTRNEIDQLPSYKFNPEVHNGDQSSCVVCMCDFELRQLLRVLPCSHEFHAKCVDKW 1107

Frog   616 LSENSTCPICR 626
            |..|.||||||
  Fly  1108 LRSNRTCPICR 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rlim	NP_001016091.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..403		75/387 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..534		14/91 (15%)
		zf-RING_2	584..626	CDD:290367	21/41 (51%)
		PDZ-binding. /evidence=ECO:0000255	636..639
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	21/41 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920