Protein Alignment BCOR and CG14073

DIOPT Version :10

• Sequence 1: NP_001116857.1
• Gene: BCOR / 54880
• HGNCID: 20893
• Length: 1755
• Species: Homo sapiens
• Sequence 2: NP_649060.1
• Gene: CG14073 / 40046
• FlyBaseID: FBgn0036814
• Length: 2133
• Species: Drosophila melanogaster
• Alignment Length: 2263
• Identity: 443/2263 - (19%)
• Similarity: 718/2263 - (31%)
• Gaps: 847/2263 - (37%)

Human    68 AALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQF-------- 124
            :|:.|.|:  .:.||..|.  .:||..|.|       |..|.|.       :|.||:
  Fly   118 SAIYMSRS--TQPGLPPPH--PHSSAQGSG-------AAGTSGS-------DPHMQYYTSNQNLA 164

Human   125 -----KPNTPETVEASAVSGKPP------NGFSAIYKT-------PPGIQKSAVATAEALGLDRP 171
                 .|:...:.::.||:...|      :|..|:|.|       ||.         |.|...:|
  Fly   165 IKKMSDPHPMWSYKSQAVTTPAPAPGLRQHGNPALYPTGSTAYWPPPD---------EQLHHQQP 220

Human   172 ASDKQSPLNINGASYLRLPWVNP--YMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLY 234
            :               |..:..|  .:.|:.|...|..:|...||.::..:.:|..|..|.   |
  Fly   221 S---------------RYSYAKPGGPVTGSRPIQGPLPNSQRYYSEDIKYSTVPAASKVLT---Y 267

Human   235 SPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPV 299
            :|..::.:.   .|||       |:|.:|....|.......:                |:|.||.
  Fly   268 APPASSSQP---QPPP-------PTSSSSANSSSVRHYELDV----------------VNPSNPS 306

Human   300 DSHAY----------PHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTY 354
            :.|..          ||.:...:.|...|...::|.|..|      |...|..:.:||.......
  Fly   307 NEHQQPSPNYGRKCPPHYETPPEQRSAGATPNSTGTPTST------SHHQSLYIPMPTFSTEKFQ 365

Human   355 SEFH---KHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQ 416
            :..|   :.|.|.:..||:                     :||:.     |..|| |.......|
  Fly   366 TTVHNAIEKYIRETPGPSL---------------------EYPRG-----GVAPV-GRTGYYNQQ 403

Human   417 DRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSE 481
            ..|...:||.: .||.|          ||.|            ||.|.   |:.||.
  Fly   404 PMKSSKAPPSV-PQTAT----------SSYV------------KMEPE---HALAGG-------- 434

Human   482 IPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPR 546
            :|:.|.|...:......|....::|:...||.|.......||           .|.||.::|  .
  Fly   435 LPQPTRSSLYHNPYNVESRERDSSPAMATVPAPHGYPTKYGK-----------LIQQQHAAS--G 486

Human   547 MG-GTDAVITNV--SGSVS-SAGRPASASPA---PNANADGTKTSRSSVETTPSVIQHVGQ---P 601
            :| |:.|...:.  .|:.| :||..||.:||   |.|.|.|| .........|.:..|..|   |
  Fly   487 VGTGSSAPYQSYYHQGTPSPAAGAVASPTPAPLPPLAEAPGT-IFGPGTGLNPGIPPHSSQPVPP 550

Human   602 PATPAKHSSSTSSKGAKAS-----------------------------NP--------EPSFKAN 629
            ||...:.:||:||..|..|                             ||        :|:::|.
  Fly   551 PANSQQPASSSSSSNANFSTLQVYPHGPDICYQPGSQTQAQNQTQNHPNPAKKSPAVTKPNYRAL 615

Human   630 ENGL-----------------------PPSS-IFLSPNEAFR------------SPPIPYPRSYL 658
            .|.:                       |.|| ...:|:...:            :||.|.|..:.
  Fly   616 INDMLKRNTASEQELNLQIIKKTLNMEPASSRNHSAPSRVIQQSAAPAAISIPSAPPPPPPAIHS 680

Human   659 P-------------------------YPAPEG----------IAVSP---LSLHGKGPV--YPHP 683
            |                         |..|:|          ..::|   .:..|..|.  .|.|
  Fly   681 PLDLSMRTVKQTADSTEYKYQRPSTDYKLPQGGLGGGLGLPRFDITPNFSAATRGGAPTSPAPTP 745

Human   684 VLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSR 748
            |:....::.|..:.|...:|..:........|.|      .:.|.::...|....:::.|...|
  Fly   746 VIRQAVAIQPAPVPPTVPVPPAVAAPALVIKTVQ------QMRPSVVETNPFAKRQQQLPPETS- 803

Human   749 SHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPN----------WNQ---------- 793
               ..:...||:     |::.|.|       |:..| ..|||          :||
  Fly   804 ---IVQVTKPTV-----ELMPTPS-------PSPHN-SSNPNYLGKKRHLQEYNQAAAKQARLDA 852

Human   794 --------GKTVVKSDKLVYV--------------DLLRE--------------------EPDAK 816
                    |..|:.:...|.|              ...||                    ||..:
  Fly   853 ESSGSLVSGAPVIAAPTSVVVVAPVPVIAVNEQALAAKREREMQSMSAESSTSAHLVPKMEPRIR 917

Human   817 TDTN-----------VSKPSFAAESVGQSAEPPKP-------SVEPALQQHRDFIALREE---LG 860
            |...           |:..:.|:.::.....||..       .:|||..:..| :.|.:|   ||
  Fly   918 TKAELKGFTFTPPVLVTSTTNASSTISPPRTPPNQITNHIQIKLEPAPPKATD-LGLDDEQHSLG 981

Human   861 RISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDG-PAVTFGKTQEDPKPF 924
            .:.|:..  |....|..:....|:..|      ||.:.|.::..|..|. |.....|.|....|.
  Fly   982 NLMDWGS--TCNNLVEQLMSKVVVPPT------LPANNPGIKLELSEDDLPVARILKRQPLAAPS 1038

Human   925 CVGSAPPSVDVTPTYTKDGADEAESND------GKVLKPK-----PSKLAKRIANSAGYVGDRFK 978
            ..|....|.....|.|.:|...:..|.      .||.:.|     ..::|.|:|...|. ....:
  Fly  1039 LAGGDAESATTQLTTTTNGISSSLGNGSGQKKLSKVEREKKRQQQEQRIAARLAPKQGQ-SSSSE 1102

Human   979 CVTTELYADSS--------------QLSREQRALQMEGLQEDSILCLPAAYCERAMMRFS----- 1024
            ..||||:..::              |.|.|..::|....:|.          |:...|.|
  Fly  1103 SDTTELHKRNTARQKKPLLRKGRTRQRSPEAASIQQSSDEEQ----------EKVSQRLSRKPRT 1157

Human  1025 ---ELEMK--------EREGGHPATKDSEMCKFS--------PADWERLKGNQDKKPKSVTLEEA 1070
               |.:.|        ::|...|:.|.:.....:        .:...:.||:::.|.:|.....:
  Fly  1158 SSEESKTKATSAKKDVKKEAKTPSNKTNNSASLTKIKKKTTDSSSLNKAKGDENPKQESQESTSS 1222

Human  1071 IAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPH--------- 1126
            .::|::::...........:..|.||::|...|:...:.:.|...|.:.:...:.|
  Fly  1223 ESDQDDNDNDNDEEEEDQEEDEEEPEEEDDDEEQDKKKEKRVGRRPGNTLKKRIAHKLNTMTRSK 1287

Human  1127 -----------SPTLRVDR---------KRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKDDW- 1170
                       |..||.|:         |||      :.....:...|..:.:.:.:|....|.
  Fly  1288 HRKELELQLANSKVLRNDKIIRNSTTKIKRK------YVRKVVDSKKEMMVTRLRNKRGMNSDLG 1346

Human  1171 ------------------------PEREM----------------------TNSSSNHLEDPHYS 1189
                                    |::::                      .|..::.|.|....
  Fly  1347 ALNGRNSKLKGSKVGNSPGKPKTSPQQQLYLEEYRYKLALKIPHSLISINKLNKVASSLPDLERR 1411

Human  1190 ELTNLKVCIELT----------GLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPE 1244
            :|:....|.:..          ...||....:||||        ..:|......||....|
  Fly  1412 DLSQELACFKRNRPKTKAASKQDFTPKSIIDVLHLR--------VTNGSTAGTQRKISVSA---- 1464

Human  1245 AIPQGTNITEEKPGRKRAEAKGNRSWSEESLK--PSDNE-------QGLPVFSGSPPMKSLSSTS 1300
              |..||:....   :.::...:.|..|:|.:  |::|:       :...:|. :..::|.:.|.
  Fly  1465 --PASTNLQIHS---ETSQTSASTSLYEQSQQDNPTENQSLDDMSKRHFSIFD-TKVLQSKTRTE 1523

Human  1301 AGGKKQAQ--------PSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTD----- 1352
            ...:|..:        |. .|||.||.              |..|.:...|.| .|||.:
  Fly  1524 TKLQKHREIIREIFVGPE-RPASAPPE--------------CVQEADGGDAIS-YQKYEEFLQQM 1572

Human  1353 ------NSEKPSGKRLCKTKHL-IPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLS 1410
                  |..|.:.:.|.:.|.: .||     .|...:|............|.:|||.|:...:.:
  Fly  1573 NSIASANDSKLARRSLMEDKSVTAPQ-----CPHKRKYRCRKGSSGFDYIRKKKRPAPTQTQNHT 1632

Human  1411 PAKQEPKPFDRL-QQLLPASQSTQLPCSSSPQETTQ-----SRPMPP----------EARRLIVN 1459
            ..:.:.:...:: |.:|..:||    .:....|.|.     |..:||          |.::.::|
  Fly  1633 QNQSQSQVSSQITQHILEHNQS----AADERLEDTDSTIAGSSHLPPKVKTEMDVCREIQKWVLN 1693

Human  1460 KNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVN 1524
            |..|::.:.:|||.|..:||:|||:....:.:.:|||||..|||||.:|||.|.|.||:|||:.:
  Fly  1694 KGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEACTQGWLEIARILLQYGANHS 1758

Human  1525 CSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGR 1589
            .:||.|.||||.|:||||.|:|||||||||||.||||||:|.:.:..|:||...|..:|:|.|..
  Fly  1759 EAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLMLASSKLMRGILRAHLSDAQSA 1823

Human  1590 NDD----DASGTWDFYGSSVCEPDDESGYDVLANPPG---------------------------- 1622
            ..|    ..:|.|:.:.:.      |.|||:.:|.|.
  Fly  1824 AADIKPMRFNGPWEIFDAK------EYGYDIFSNVPNTACDMSRALRKERKEAKQQRMSSNSDRT 1882

Human  1623 ---------------PEDQDD-------------------------------------------- 1628
                           |||.|.
  Fly  1883 SNLNGLLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTTTATTMVKLELGTDEDSNNNK 1947

Human  1629 --------------------------------------------------------------DDD 1631
                                                                          |.:
  Fly  1948 NNEELNANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKANTNSSTRLDEDQTDIETMDSE 2012

Human  1632 AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCN--FPN-------- 1686
            ...|:||||.::.||.|.|.::   .:|...|:||:|:...||:.|:....|  .||
  Fly  2013 LNGDIFEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVKSKDTLLNKLCPNNSNALASS 2074

Human  1687 -VEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLG 1738
             ..::...:.:.:.:.:..|...|:.  |..|..|...:.|:::.:.::.|||
  Fly  2075 QKHLLREFKIDDFLEKATCLQLLCAG--EKLNMFSSSKVVLIKYNDSVRNLLG 2125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCOR	NP_001116857.1	Herpes_BLLF1	<257..673	CDD:282904	107/549 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..345		7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..438		13/49 (27%)
		Interaction with BCL6	498..514		4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..641		33/153 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..760		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	773..794		7/48 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	815..844		5/46 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1071..1187		23/191 (12%)
		BCOR	1202..1414	CDD:434953	48/240 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1220..1328		22/124 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1430..1451		5/25 (20%)
		ANKYR	<1461..1593	CDD:440430	69/135 (51%)
		ANK 1	1462..1495		10/32 (31%)
		ANK repeat	1463..1494	CDD:293786	10/30 (33%)
		ANK repeat	1496..1527	CDD:293786	18/30 (60%)
		ANK 2	1496..1525		18/28 (64%)
		ANK repeat	1529..1558	CDD:293786	22/28 (79%)
		ANK 3	1529..1558		22/28 (79%)
		Necessary and sufficient for interaction with PCGF1	1634..1748		29/116 (25%)
		PUFD	1634..1747	CDD:465171	29/116 (25%)
CG14073	NP_649060.1	PHA03247	<123..554	CDD:223021	126/582 (22%)
		TolA	1068..>1213	CDD:442298	26/155 (17%)
		ANKYR	<1686..1846	CDD:440430	75/165 (45%)
		ANK repeat	1697..1728	CDD:293786	10/30 (33%)
		ANK repeat	1730..1761	CDD:293786	18/30 (60%)
		ANK repeat	1763..1788	CDD:293786	18/24 (75%)
		PUFD_like	2016..2129	CDD:271222	29/115 (25%)