DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TOR4A and RPT3

DIOPT Version :9

Sequence 1:	NP_060193.2	Gene:	TOR4A / 54863	HGNCID:	25981	Length:	423	Species:	Homo sapiens
Sequence 2:	NP_010682.3	Gene:	RPT3 / 852003	SGDID:	S000002802	Length:	428	Species:	Saccharomyces cerevisiae

Alignment Length:	352	Identity:	63/352 - (17%)
Similarity:	118/352 - (33%)	Gaps:	99/352 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    78 TFDSPAELPSRTPRKKRRRSRLV--LYPETSRKYRPRVEHRSRAQRCLLLLVAIVGFQVLNAIEN 140
            |.|.....||.:....|..:.||  |.|::...                  ::::|       ||
Yeast   125 TLDRELLKPSMSVALHRHSNALVDILPPDSDSS------------------ISVMG-------EN 164

Human   141 LDDNAQRYDLDGLEKALQRAVFGQPAAVSRIVALMRDYLATHVHSRPLLLALHGPSGVGKSHVGR 205
            ...:....|:.||:  :|:....:...:..:.|.:.:.:..   ..|..:.|:||.|.||:.:.:
Yeast   165 EKPDVTYADVGGLD--MQKQEIREAVELPLVQADLYEQIGI---DPPRGVLLYGPPGTGKTMLVK 224

Human   206 LLARHFRSV---LEDSALVLQYHARHHCPEARAAQDCREELARRVADVVARAEAEEKTPLLVLDD 267
            .:|...::.   :..|..|.:|..               |..|.|.||. |...|....::.:|:
Yeast   225 AVANSTKAAFIRVNGSEFVHKYLG---------------EGPRMVRDVF-RLARENAPSIIFIDE 273

Human   268 VELMPRPLLDELHGFLQPQRSHHFHNAIYVLLSGAGGAEVTRFVLQNASRALPLRPDGFRSAEAA 332
            |:.:.....|...|                     ...||.|.:::     |..:.|||
Yeast   274 VDSIATKRFDAQTG---------------------SDREVQRILIE-----LLTQMDGF------ 306

Human   333 AAQAEEDLRASLLAVLSREHPLWQAAAIVPFLL----LDKRDVVSCFRDEMAGEGFFPDQARAEN 393
                ::.....::...:|      |..:.|.||    ||::......||.......|...|...:
Yeast   307 ----DQSTNVKVIMATNR------ADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFGTIASKMS 361

Human   394 LAAQLSFYRVAGREFAVTGCKQVVATV 420
            ||.:.....:..|..:::|.  |:|.:
Yeast   362 LAPEADLDSLIIRNDSLSGA--VIAAI 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TOR4A	NP_060193.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..68
		P-loop_NTPase	149..253	CDD:304359	21/106 (20%)
		AAA	186..>290	CDD:214640	22/106 (21%)
RPT3	NP_010682.3	PTZ00454	46..428	CDD:240423	63/352 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910