Protein Alignment CC2D1A and l(2)gd1

DIOPT Version :10

• Sequence 1: NP_060191.3
• Gene: CC2D1A / 54862
• HGNCID: 30237
• Length: 951
• Species: Homo sapiens
• Sequence 2: NP_001245976.1
• Gene: l(2)gd1 / 34543
• FlyBaseID: FBgn0261983
• Length: 834
• Species: Drosophila melanogaster
• Alignment Length: 902
• Identity: 311/902 - (34%)
• Similarity: 465/902 - (51%)
• Gaps: 161/902 - (17%)

Human     1 MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLM-IP----------EDGANDEELEAEFLALVGG 54
            |..||.|.      .|..||    .|||..||. ||          ||...|.:||||..|:.||
  Fly     1 MFSRKKPE------PAKRRQ----HDLSQFGLTEIPDDFDPSAGYGEDDGGDSDLEAELAAITGG 55

Human    55 QPPALEKLKGKGP-LPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKAS 118
            : .|..|.|.|.. ||...::||.:..:||..:|:    |:|:||:|.|||.||:.:.|.|:  :
  Fly    56 E-GAKPKPKPKAKLLPASDLDKMIADSLRDVSDDD----DDDNLESDPDLLGELSGIGGLEE--A 113

Human   119 ETPPPVAQPKPEAPHP---GLETT-------LQERLALYQTAIESARQAGDSAKMRRYDRGLKTL 173
            |...|||||...:..|   .|.||       :::||.:|:.|..:|:.||||.|.||:.||||||
  Fly   114 EEEEPVAQPPAASEEPVQTFLPTTTVDTLSIIKQRLEMYKQAEANAKTAGDSGKARRFGRGLKTL 178

Human   174 ENLLASIRKGNAIDEADIPPPVAI----GKGPASTPTYSPAPTQPA--PRIAS--APEPRVTLEG 230
            ::|......|.:|:..||||.|::    |:.|......||||:.||  |.:.|  ||:|
  Fly   179 KDLHRQAAAGKSINVDDIPPEVSVKPIGGQAPPVPAEESPAPSTPASPPPVPSRAAPDP------ 237

Human   231 PSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDA 295
            |:...|........|..||.|.    :.|::|||.|||.|||.:|:.||.:.|.:..:|.|.||.
  Fly   238 PTPGTPVEPTTSVAPTSPPNPL----VTQMRSRQTDYKAAALQSKRSGDISTALQFLKVVKQFDV 298

Human   296 VLEALSRGEPVDLSCLPPPPDQL------------------PPDPPSPPSQPPTPATAPSTTEVP 342
            |::....|:.||||.:||||.:.                  |...|.|....|.|..|.:|
  Fly   299 VIKMCEDGQEVDLSDMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAPEPTPVAPAPVLAAAT---- 359

Human   343 PPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPP 407
                .:||||:||:|:||...|.||::.:..|||...||||||:|||:.:|||:.|...||||||
  Fly   360 ----NMLEALQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKPVPYDELPVPP 420

Human   408 GFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQ 472
            ||.|:       ||                .|..|......:|....|| .|||...|  ..||.
  Fly   421 GFGPL-------PT----------------ADAAPVAPTPSLPTSPTSP-PPTASTSA--GGTPS 459

Human   473 SGSA--PTA--KAP----PKATSTR----------AQQQLAFLEGRKKQLLQAALRAKQKNDVEG 519
            |.||  |||  |||    ||..:||          |:||:..|..|:|:...||:.||:..:::.
  Fly   460 SSSATTPTAPRKAPSPPKPKELTTRTSGNQQKNNIAEQQMKLLLERQKEFKLAAIEAKKAGEIDQ 524

Human   520 AKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDD----FALVQR----PGPGLSQEAARRY 576
            ||.:|:..||.:.:|.|:.:|||||::.:|..|..:|:    ||:|..    |...:.:...|..
  Fly   525 AKEYLKIFKGFDSLLNAASSGLPVDLSTLPVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRME 589

Human   577 GELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQR 641
            .:|.|    |..||.|..:....:|::....:||.||...::.:|:::.:..:..|.|...:|:|
  Fly   590 EQLAK----QLMMCKNTRDHHKAMGDVAGMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKR 650

Human   642 TFSVIKIFPDLSSNDMLLFIVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTD 706
            :|:::....||:.:::.:.:|:||:...   .:|.|:|.:||.:||..| :|:.|.||:||::|.
  Fly   651 SFNIVHCNTDLTDSELEIVVVRGISYNV---ANPKDVDTYVRVEFPLLN-DESFKTKTNVIRDTS 711

Human   707 SPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKG------------------GLFKTDRVLGT 753
            ||::.|:||:.|.|::|.|:|..:..|:|||:..:|                  |..::|.::||
  Fly   712 SPDYDERFKVDIQRTNRQFQRIFKRHGVKFEIYSRGCSIDCCGLSRKLPLCCFRGFLRSDTLIGT 776

Human   754 AQLKLDALEIACEVREILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVID 810
            ..:||..||..||:.:..:::|||:..||:|||.:|:|.|:..:|:|..||:|||:|
  Fly   777 VNVKLQPLETKCEIHDTYDLMDGRKQVGGKLEVKIRVRNPILTKQMEHITEKWLVLD 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CC2D1A	NP_060191.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..139		23/61 (38%)
		PHA03247	<116..477	CDD:223021	143/398 (36%)
		DM14	140..195	CDD:128928	25/54 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..266		29/88 (33%)
		DM14	257..310	CDD:128928	23/52 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..346		15/57 (26%)
		DM14	349..407	CDD:128928	32/57 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..491		24/71 (34%)
		DM14	494..552	CDD:128928	20/57 (35%)
		C2_Freud-1	652..809	CDD:176072	61/174 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..841
		chemoreceptor_sensor	851..918	CDD:444710
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	25/57 (44%)
		DM14	260..318	CDD:128928	26/57 (46%)
		DM14	362..420	CDD:128928	32/57 (56%)
		DM14	499..557	CDD:128928	20/57 (35%)
		C2_Freud-1	661..832	CDD:176072	61/174 (35%)