Protein Alignment CC2D1A and cc2d1a

DIOPT Version :10

• Sequence 1: NP_060191.3
• Gene: CC2D1A / 54862
• HGNCID: 30237
• Length: 951
• Species: Homo sapiens
• Sequence 2: NP_001120385.1
• Gene: cc2d1a / 100145460
• XenbaseID: XB-GENE-5799124
• Length: 973
• Species: Xenopus tropicalis
• Alignment Length: 989
• Identity: 518/989 - (52%)
• Similarity: 690/989 - (69%)
• Gaps: 75/989 - (7%)

Human    12 GRGAAAARQLGLLVDLSP-DGLMIPEDGANDEELEAEFLALVGG-QPPALEKLKGKGPLPMEAIE 74
            |:||.||::...|:...| |...|.:||:    ||||.|||.|| |....||.|||.||||||||
 Frog    11 GKGAPAAKRPPFLLGGFPTDDDDIEDDGS----LEAELLALTGGHQSKGKEKPKGKSPLPMEAIE 71

Human    75 KMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLG---EEQKASETPPPVAQPKPEAPHPGL 136
            |||:|||:|.::|     |.::|:.|:||||||:||||   ||:.....|||.|.|..|.   |:
 Frog    72 KMAALCMQDIEDD-----DGEELDDDEDLLAELDEVLGDEVEEKPKVAAPPPQAAPSSER---GM 128

Human   137 ETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGK-- 199
            |.||.||||:|:.|:.:|:|.|:|:|.|||:||:||||:|:.|::||.::...|||||||:||
 Frog   129 EGTLTERLAMYKDALTNAKQGGESSKARRYERGVKTLEDLIRSVQKGKSVSPEDIPPPVAVGKTE 193

Human   200 -GPASTPT-------YSPAPTQPA------PRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
             .|.:.|.       ..|.|..|.      |.....|.|:|..:..:...|.|||. |.|...|.
 Frog   194 NAPVTAPAAPLLDQPLKPQPVSPVLQGPPKPHAPLRPPPQVPAKPQTLPKPVSSPA-AVPLSAPA 257

Human   251 PCSPG---PLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLP 312
            ..|||   ..|::..|||:||||||..|::|||..|::::|:|||.|.:|.|:..|:.||:..||
 Frog   258 APSPGSDEDRARVLERQREYKLAALQQKREGDTETASKYYRIAKSLDPMLSAMDSGDKVDIKSLP 322

Human   313 PPPDQLPPDPP--SP--------------PSQPPTPA-----TAPS-TTEVPPPPRTLLEALEQR 355
            ||||::..:.|  :|              |...|..|     |.|| ::::|||||..||||:||
 Frog   323 PPPDKMLVNKPLAAPTSENAMHTTSSDKLPVNKPVVALSSVNTGPSPSSDLPPPPRDTLEALQQR 387

Human   356 MERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP 420
            |:||:.||.|||.|||.||||||||||||||||||:||||:||::||||||||||||||.:.: .
 Frog   388 MDRYRSAAEQAKGKGDDRKARMHERIVKQYQDAIRSHKAGKAVNLAELPVPPGFPPIQGSDPS-A 451

Human   421 TQQSLVGVLETAMKLANQDEGP-EDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPK 484
            .:||:||||||||:||||.||. :|:.||..:|...|...:..|: |..:.||:....|....||
 Frog   452 QEQSIVGVLETAMRLANQKEGDGDDDSDEEGEKPTEPQKLSPHPR-PAGQPPQAAPKATPSKSPK 515

Human   485 ATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVP 549
             .|.:|||||.|||||:||||.||||:||:.|:||||..|||:|||:||:||:|.||||||||||
 Frog   516 -MSGKAQQQLDFLEGRRKQLLAAALRSKQQRDLEGAKNFLRQSKGLDPMIEAARGGLPVDITKVP 579

Human   550 PAPVNKDDFALVQ--RPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKL 612
            |||:|:.||:|.|  |.|..|:.|   :|.:|.:.:::|||||:::|.|||.|||||||.|:|||
 Frog   580 PAPINEADFSLDQQRRGGGSLNTE---KYQQLMEKLKEQHEMCVSYSRQFTHLGNITETAKYEKL 641

Human   613 AEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGINLPTPPGLSPGD 677
            ||:|.:.:::||||..||||.|...||:||.:::||||:|||:|:::.:.|.:|||.|.|.||.|
 Frog   642 AEECMKYIELLKQAHSRGLPVPGYHFEERTINIMKIFPELSSSDLVVIVAKAVNLPIPSGSSPHD 706

Human   678 LDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKG 742
            :|.||||:|.||::||||||||:|||:::||.|||:|.|.|||:|||.:||||.||||||::.||
 Frog   707 MDTFVRFEFAYPSMEEAQKDKTNVIKSSNSPVFKEKFTLHINRNHRGLKRAIQAKGIKFEIIQKG 771

Human   743 GLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWL 807
            ||||:||:|||:.|||:|||.:||:|:|:||:|||:.|||:|||:|||||||::|||.:|||:||
 Frog   772 GLFKSDRLLGTSLLKLEALEGSCEIRDIMEVMDGRKTTGGKLEVIVRIREPLSSQQLSSTTEKWL 836

Human   808 VIDPVPAAVPTQVAGPKGKAPPVPAPARESGNRSARPLHSLSVLAFDQERLERKILALRQARRPV 872
            ||||:  .:| .|:.||   |...||.:.:|. |.:.||||:|||:::|:||:|:.:.:|..|..
 Frog   837 VIDPI--TLP-PVSAPK---PKQTAPVKPTGG-STQNLHSLTVLAYEKEKLEKKMHSYKQQHRAA 894

Human   873 PPEVAQQYQDIMQRSQWQRAQLEQGGVGIRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALY 937
            |.::..|..||.:|||.|...|.|||...|.||..||||.||||.:||||||.:|:|:|||:|||
 Frog   895 PDDLVGQINDITRRSQQQIQFLRQGGPSARAEYVRQLERYLQFYGDAARRLGQEGNREAAKDALY 959

Human   938 RRNLVESELQRLRR 951
            :|.||.|||.:..:
 Frog   960 KRTLVTSELHKFNQ 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CC2D1A	NP_060191.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..139		27/61 (44%)
		PHA03247	<116..477	CDD:223021	186/402 (46%)
		DM14	140..195	CDD:128928	29/54 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..266		31/99 (31%)
		DM14	257..310	CDD:128928	25/52 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..346		19/61 (31%)
		DM14	349..407	CDD:128928	46/57 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..491		17/54 (31%)
		DM14	494..552	CDD:128928	43/57 (75%)
		C2_Freud-1	652..809	CDD:176072	102/156 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..841		7/22 (32%)
		chemoreceptor_sensor	851..918	CDD:444710	31/66 (47%)
cc2d1a	NP_001120385.1	DM14	132..187	CDD:128928	29/54 (54%)
		PRK12323	<184..>261	CDD:481241	23/77 (30%)
		DM14	268..325	CDD:128928	28/56 (50%)
		DM14	381..439	CDD:128928	46/57 (81%)
		DM14	524..582	CDD:128928	43/57 (75%)
		C2_Freud-1	681..838	CDD:176072	102/156 (65%)