Protein Alignment CC2D1A and cc2d1a

DIOPT Version :10

• Sequence 1: NP_060191.3
• Gene: CC2D1A / 54862
• HGNCID: 30237
• Length: 951
• Species: Homo sapiens
• Sequence 2: XP_001341323.7
• Gene: cc2d1a / 100001297
• ZFINID: ZDB-GENE-110908-1
• Length: 1012
• Species: Danio rerio
• Alignment Length: 1040
• Identity: 505/1040 - (48%)
• Similarity: 676/1040 - (65%)
• Gaps: 123/1040 - (11%)

Human     1 MHKRKGPPGPPGRGAAAARQLGLLVDLSPD-GLMIPEDGANDEELEAEFLALVGGQPPAL----- 59
            |.:.:.|| ..|:|||.|:|:|||:||:|| ||  .:.|.|:.|||||.:||:||.....
Zfish     1 MSRSRNPP-QKGQGAARAKQMGLLLDLAPDSGL--DDSGGNEAELEAELMALMGGGGGGRGGAGG 62

Human    60 EKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVL-GEEQKASETPPP 123
            :|..||.|:.||.||:||:|||:|.|||   |.::.|||.|.|||||||||| .:|::....|||
Zfish    63 KKPGGKAPVAMEDIERMAALCMKDLDED---GDEDGDLENDADLLAELNEVLEDDEEEVVRKPPP 124

Human   124 VAQPKPE----APHP-------GLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLL 177
            ...| |:    ||.|       .||:.|||||.:|||||.:|:.||:|:|:||||||||||:::|
Zfish   125 SPVP-PQRSNVAPQPVSQNASGSLESRLQERLDMYQTAINNAKAAGESSKVRRYDRGLKTLQSML 188

Human   178 ASIRKGNAIDEADIPPPVAI-GKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGP-SATAPASSP 240
            ||::||..|:|.:||||||. ||...:||. .|...|.||.:     |:...|.| ..:.||:.|
Zfish   189 ASVKKGKPINEEEIPPPVATGGKSTPATPA-EPIREQEAPAL-----PQTANEKPLQDSRPAAPP 247

Human   241 GLAKPQM--PP--------------GPCSPG-PLAQ-------LQSRQRDYKLAALHAKQQGDTT 281
               |||:  ||              .|.:|. |.||       :.||||:|||||:.|||.|:|.
Zfish   248 ---KPQLLQPPAQRVTALTPETPAISPLTPAQPNAQHSELKASVLSRQREYKLAAIKAKQSGNTE 309

Human   282 AAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQL------PPDPPSPPSQPPTPATAPSTTE 340
            .|.:.:.|:|:.|:|:||:.|||.|||..|||||..:      ||...|.|:..|.|..||:.|.
Zfish   310 QAKQLYHVSKTLDSVVEAVDRGEMVDLRSLPPPPGDVEVPQSNPPQQISKPAAAPAPPAAPANTA 374

Human   341 VPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPV 405
            : ..||::.|||:|||::|:.||..||||||:||||||:||:|||||||:|.||||.|::|:|||
Zfish   375 L-SAPRSVAEALQQRMDKYKEAAEAAKSKGDERKARMHQRIIKQYQDAIKAQKAGRPVNLADLPV 438

Human   406 PPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQN------SPVAPTAQPK 464
            |||.||:||.|:   ..|:|:||||.|:||||||   .|.|:|.|:|.|      ..:.|:|||.
Zfish   439 PPGCPPLQGAES---GDQNLMGVLENAVKLANQD---ADAEEEEPQKVNIMAHTSCILQPSAQPA 497

Human   465 APPSRTPQSGSAPTAKAPPKATST---------------RAQQQLAFLEGRKKQLLQAALRAKQK 514
            ...||.|         |||||:||               :|||||.||..|::|.::||||:|:.
Zfish   498 VQKSRAP---------APPKASSTAGTPTGSTNTPKMGGKAQQQLDFLTMRRQQFIKAALRSKEM 553

Human   515 NDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGEL 579
            .|::||..|||.||||:||:.|::.||||||||||.|||:.:|:.|.|.....:|..:|.:|.:|
Zfish   554 KDMQGAAQHLRNAKGLDPMITAAKGGLPVDITKVPAAPVSDEDYRLSQSRSSAVSPRSAEQYRQL 618

Human   580 TKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFS 644
            .:.::||||.||.:|.|||.:|||.||.:||||||:|..|:||||:|..:|...|....|:|||:
Zfish   619 MEQLKQQHEKCLAYSQQFTHMGNIAETARFEKLAEECMNSIDILKKAHAKGRSVPKYHTEERTFN 683

Human   645 VIKIFPDLSSNDMLLFIVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPE 709
            .:||||:|::|:|:|:||||||||.|||.|..|||..|||:||:|:.|||||||||.:|||:|||
Zfish   684 TVKIFPNLTANEMMLYIVKGINLPPPPGGSANDLDASVRFEFPFPSAEEAQKDKTSTVKNTNSPE 748

Human   710 FKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVL 774
            |||||||.|.|.||||||.:|.||||.||||||||||.|:|:|:|||||:|||..||:|||::||
Zfish   749 FKEQFKLNIKRDHRGFRRVVQAKGIKLEVVHKGGLFKNDKVVGSAQLKLEALENQCEIREIVDVL 813

Human   775 DGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPP-------VPA 832
            |||:.|||:|||.|:|||||...||::.||:|||:||:..:........|.:.|.       .|:
Zfish   814 DGRKATGGKLEVRVKIREPLAGSQLQSVTEKWLVLDPLTPSPEKHREQQKDREPEKGREKERAPS 878

Human   833 PARESGN-------RSARP----LHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQR 886
            |..:..|       .|:.|    |||.|:|..|:||||.||...::.||. |.||.:|:.|:.||
Zfish   879 PRSKPRNDHDRNHKTSSSPPQYKLHSFSLLHHDKERLEWKINEYKKNRRD-PSEVIKQHMDVCQR 942

Human   887 SQWQRAQLEQGGVGIRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR 951
            .|||::.||:....: .||...|.:.:...:::.:...|.|:|:|||:||.|..:||:||:.:|:
Zfish   943 LQWQKSYLEKHPAAL-TEYENVLRKFVHGLSDSVKTFSNQGNREAAKDALGRLKMVENELESVRK 1006

Human   952  951
            Zfish  1007  1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CC2D1A	NP_060191.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..139		32/70 (46%)
		PHA03247	<116..477	CDD:223021	189/409 (46%)
		DM14	140..195	CDD:128928	35/54 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..266		35/106 (33%)
		DM14	257..310	CDD:128928	29/59 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..346		17/45 (38%)
		DM14	349..407	CDD:128928	40/57 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..491		23/74 (31%)
		DM14	494..552	CDD:128928	33/57 (58%)
		C2_Freud-1	652..809	CDD:176072	109/156 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..841		5/36 (14%)
		chemoreceptor_sensor	851..918	CDD:444710	25/66 (38%)
cc2d1a	XP_001341323.7	DM14	151..206	CDD:128928	35/54 (65%)
		DM14	286..343	CDD:128928	30/56 (54%)
		DM14	383..440	CDD:128928	40/56 (71%)
		DM14	533..591	CDD:128928	33/57 (58%)
		C2_Freud-1	694..848	CDD:176072	108/153 (71%)