DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nalcn and para

DIOPT Version :9

Sequence 1:XP_005167755.1 Gene:nalcn / 548345 ZFINID:ZDB-GENE-050410-12 Length:1743 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2081 Identity:401/2081 - (19%)
Similarity:720/2081 - (34%) Gaps:670/2081 - (32%)


- Green bases have known domain annotations that are detailed below.


Zfish    24 PSMLKRKQSSRVEAQPMTDFGP--DETLT-------------DSADILWINKPW----------- 62
            |..|:......:.:.|:.|..|  ...||             .::..:|:..|:           
  Fly    86 PVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYIL 150

Zfish    63 VHSLLRACAIISVISVC----MNTPKTFEHYPPLQYVTFALDTLLMFLYTAEMIAKMHIRGIIKG 123
            ||.|.....|.:::..|    |.|..|.|          :.:.:...:||.|...|:..||.|..
  Fly   151 VHPLFSLFIITTILVNCILMIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFILC 205

Zfish   124 ENSYVKDRWCMFDGFMVVFLWVSLVLQVFEIAELVDQMSPWGMLRIPRALIMIRVFRIYFRFELP 188
            ..:|::|.|...|..::...:|::.:.:..:|.|       ...|:.|||..:.:        :|
  Fly   206 PFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAAL-------RTFRVLRALKTVAI--------VP 255

Zfish   189 RSR-ITNILKRSGEQIWSVTIFLLFFLLLYGILGVQMF-GTFNHHCV------------TNET-- 237
            ..: |...:..|.:.:..|.|..:|.|.::.::|:|:: |.....|:            |:|.  
  Fly   256 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWD 320

Zfish   238 --EKEKVTWNS----LAIPDTHCSPNGEGYQCPVGFKCVDLEDYGLSRQELGYSGFNELGTSIFT 296
              .:....|.|    ::.|  .|.......||...:.|  |:.:| .....||:.|:..|.:..:
  Fly   321 YHNRNSSNWYSEDEGISFP--LCGNISGAGQCDDDYVC--LQGFG-PNPNYGYTSFDSFGWAFLS 380

Zfish   297 VYEAASQEGWVFIMYRAIDSFPRWRSYFYFLTLIFFLAWLVKNVFIAVIIETFAEIRVQ------ 355
            .:...:|:.|..:....:.:...|...| |:.:||..::.:.|:.:|::..::.|::.:      
  Fly   381 AFRLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEA 444

Zfish   356 ----------------------------------------------------------------- 355
                                                                             
  Fly   445 AEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEK 509

Zfish   356 ------------------------------------------------------FQQMWGSRSS- 365
                                                                  |....||||| 
  Fly   510 GNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSH 574

Zfish   366 ------------------------------------TTSTATTQM-------------------- 374
                                                ..|.|.|.|                    
  Fly   575 KYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRH 639

Zfish   375 -------------FHEDASGGWQLVAV-----------------------------DVN------ 391
                         .|.|..||..::.|                             |.|      
  Fly   640 SSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHR 704

Zfish   392 -----------------------KP-------------------------HGRA----------- 397
                                   :|                         |.||           
  Fly   705 DYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFP 769

Zfish   398 -----------------------------PAC-----LQQLMRSSVF----HMFILSMVAVDVIV 424
                                         ..|     .|:.:...||    .:||...:.|:.:.
  Fly   770 TEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMF 834

Zfish   425 AASNYH----RGDHKLTNDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFESLLVVGTT 485
            .|.::|    ..:..|.:..::     ||..|.:||.:|:..:....|.....:.|:.::|..:.
  Fly   835 MAMDHHDMNKEMERVLKSGNYF-----FTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSL 894

Zfish   486 LHIYPDLYH--SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGK-KLGSLVVFTASLLIVMSAIS 547
            |.:..:...  |....|::|||.:|.|..|.| :.:..|.|... .||:|......::.:.:.:.
  Fly   895 LELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMG 958

Zfish   548 LQMF---------CFVE-DLDR--FTTFPRAFMSMFQILTQEGWVDVMDQTLVAVGQMWAPVVAI 600
            :|:|         .|.: ||.|  ||.|..:||.:|::|..| |::.|...:........|    
  Fly   959 MQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIP---- 1018

Zfish   601 YFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQ 665
            :|:...:...|::|:||:|::|.|.       ....|....|:.||.       :|.|.| ||..
  Fly  1019 FFLATVVIGNLVVLNLFLALLLSNF-------GSSSLSAPTADNDTN-------KIAEAF-NRIG 1068

Zfish   666 MVK--ISKLPSD-FTVPRIRESFMKQFIDRQQQDPSCLFRRLPSASSSSC-----DHSKRSAIED 722
            ..|  :.:..:| |.:  ||.....|..|:...:.:.....:.|.....|     :|.       
  Fly  1069 RFKSWVKRNIADCFKL--IRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHG------- 1124

Zfish   723 NKYIDQKLRKSVFSIRARNLMEKEITVNKILRACTRQRM---LSGSFEGQPTKERSILSVQHHIR 784
                |.:|......|.|..|::|.|.....|.......|   :.|..:....|:...|:  :...
  Fly  1125 ----DNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLN--NATD 1183

Zfish   785 QERRSLR-HGSTSQR----ISRGKSLETLTQDHSSTVRYRNAQREDSEIKMIQEKKEQAEMKR-- 842
            .:..|:. :||...|    .|...|.||:..:..     |:|.:||  :.:.:|..|:.|.:.  
  Fly  1184 DDTASINSYGSHKNRPFKDESHKGSAETMEGEEK-----RDASKED--LGLDEELDEEGECEEGP 1241

Zfish   843 -------KVQEEELRENHP-------YFDKPLFIVGREHRFRNFCRMIVRARFNASNTDPNTGAV 893
                   ...:|::.:.:|       |:.|...:.|.:                           
  Fly  1242 LDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDD--------------------------- 1279

Zfish   894 NSTKYHQLYDLLGLVT-------YLDWVMIVVTICSCISMMFESPFTRVMHVP-------TLQIG 944
             .:.:.|.:..|.|.|       |.:..:|.:.:.|.:::..|.     :|:|       .|...
  Fly  1280 -DSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALED-----VHLPQRPILQDILYYM 1338

Zfish   945 EYVFVIFMSIELNLKIMADG--LFFTPTAVIRDFGGVMDIFIYLVSLIFLCWLPNNVPPESGA-- 1005
            :.:|.:...:|:.:|.:|.|  ::||......||      .|.:||||      |.|....||  
  Fly  1339 DRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDF------VIVMVSLI------NFVASLVGAGG 1391

Zfish  1006 ----QLLMMLRCFRPLRIFKLVPQMRKVVREVLKGFKEIFLVSILLLTLMLVFATFGVQLFAGKL 1066
                :.:..||..||||....:..||.||..:::....||.|.::.|...|:||..||||||||.
  Fly  1392 IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1456

Zfish  1067 AKCNDPH--------ISSKDDCHGIFRINVSISKNLNLKLKDGEKKPGFWVPRVWANPRNFNFDN 1123
            .||.|.:        |.:::.|.         |:|.                 .|.|.. .|||:
  Fly  1457 FKCEDMNGTKLSHEIIPNRNACE---------SENY-----------------TWVNSA-MNFDH 1494

Zfish  1124 VGNAMLALFEVLSLKGWVEV-RDVIIHR---VGPIH--GIYIHV----FVFLGCMIGLTLFVGVV 1178
            ||||.|.||:|.:.|||::: .|.|..|   ..||.  .||:::    |:..|....|.||:||:
  Fly  1495 VGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVI 1559

Zfish  1179 IANFNENKGTA------LLTVDQRRWEDLKSRLKIAQPLHLPPRPENGGFR--AKMYDITQHPFF 1235
            |.||||.|..|      .:|.||:::.:...::...:||...|||.   :|  |.:::|.....|
  Fly  1560 IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPR---WRPQAIVFEIVTDKKF 1621

Zfish  1236 KRGIAVLV-LAQSVLLSVKWDELGAVTFPLATMSVVFTFIFVLEVTMKLIAMSPAGYWQSRRNRY 1299
            ...|.:.: |....:...::|........|..::.:|..||..|..:|:.|:. ..|:....|.:
  Fly  1622 DIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYFIEPWNLF 1685

Zfish  1300 DLLVTSLGLIWIILHFALQNAYTYMMGTCVIVFRFFTICGKHVTL-------KMLLLTVVVSMYK 1357
            |::|..|.::.::|...::.  .::..|.:.|.|...: |:.:.|       :.||..:.:|:..
  Fly  1686 DVVVVILSILGLVLSDIIEK--YFVSPTLLRVVRVAKV-GRVLRLVKGAKGIRTLLFALAMSLPA 1747

Zfish  1358 SFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSTAGKAITVLIRIVTGEDWNKIMHDCM 1422
            .|.|.:.:||::..:|..|:..|..||....||...||.|.|:::.:|.::.|...|:.:: |.:
  Fly  1748 LFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVL-DAI 1811

Zfish  1423 VQPPFC-TPDKHRYWETDCGNYAGALIYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQL-L 1485
            :....| .||..:.:..:||:....:.:..|:.||...|::|:.:|:|:||:|  .:||:.|. |
  Fly  1812 INEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYS--QATEDVQEGL 1874

Zfish  1486 SYNDLRHFQIIWNMVDDKREGVIPTSRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGD 1550
            :.:|...:..||...|.:....|...::...|.:|...|::....     |:....|:.....||
  Fly  1875 TDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPN-----KYKIISMDIPICRGD 1934

Zfish  1551 VTF-HDVLSML-----SYRSVDIRKSLQLEELLAR------EQLEYTI----EEEVAKQTIRMWL 1599
            :.: .|:|..|     :.:...|.::.::.|:.||      |.:..|:    ||..|:.....|.
  Fly  1935 LMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWR 1999

Zfish  1600 K 1600
            |
  Fly  2000 K 2000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nalcnXP_005167755.1 Ion_trans 85..355 CDD:278921 56/291 (19%)
Ion_trans 429..626 CDD:278921 51/215 (24%)
Ion_trans 926..1184 CDD:278921 87/290 (30%)
Ion_trans 1263..1481 CDD:278921 56/225 (25%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 59/301 (20%)
Na_trans_cytopl 515..648 CDD:288761 10/132 (8%)
Ion_trans 835..1028 CDD:278921 45/203 (22%)
Na_trans_assoc 1054..1296 CDD:284034 53/299 (18%)
Ion_trans 1318..1571 CDD:278921 90/296 (30%)
Na_channel_gate 1561..1613 CDD:240441 16/54 (30%)
Ion_trans 1636..1871 CDD:278921 58/241 (24%)
GPHH 1880..1930 CDD:293510 9/54 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.840

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